Urothelial Cancer
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04) [Phase 1, Phase 2]
This is a Clinical Trial Update for KEYMAKER-U04, a Phase 1/2 study evaluating new treatments given with enfortumab vedotin and pembrolizuma…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031) [Phase 3]
This document announces a Phase 3 clinical trial (MK-2870-031) evaluating sacituzumab tirumotecan for bladder/urothelial cancer, which is cu…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Acupuncture and Exercise for EV-Pembro-Induced Peripheral Neuropathy [NA]
A clinical trial is evaluating acupuncture and exercise to manage peripheral neuropathy caused by enfortumab vedotin plus pembrolizumab in p…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial Cancers [Phase 1]
A first-in-human Phase 1a/1b study of CT-202, a nectin-4 directed bispecific antibody, in patients with recurring triple-negative breast can…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2) [Phase 2, Phase 3]
Clinical trial update for BT8009-230 in metastatic urothelial cancer shows ongoing Phase 2 and Phase 3 studies. The current status is Active…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer [Phase 1, Phase 2]
The document describes a Pfizer-sponsored clinical trial investigating PF-08634404 alone or in combination with Enfortumab Vedotin for uroth…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors [Phase 1]
Phase 1 clinical trial update showing LY4052031 being studied in advanced or metastatic urothelial cancer and other solid tumors; the study …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Bortezomib With Gemcitabine/Doxorubicin in Patients With Urothelial Cancer and Other Solid Tumors [Phase 1]
Phase 1 trial of bortezomib in combination with gemcitabine and doxorubicin for urothelial cancer and other solid tumors; the study is curre…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy [Phase 2, Phase 3]
Update on a Phase 2/3 trial comparing Izalontamab Brengitecan with platinum-based chemotherapy for metastatic urothelial cancer that progres…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: DK222 Study at Hopkins [Phase 1]
This document provides a status update on the Phase 1 DK222 study at Johns Hopkins, which is currently recruiting. The trial targets non-sma…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma [Phase 2, Phase 3]
A Phase 2/3 clinical trial update evaluating datopotamab deruxtecan plus platinum chemotherapy versus gemcitabine plus platinum in locally a…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03) [Phase 2]
AstraZeneca's Dato-DXd is being studied as a single agent and in combination with other anti-cancer drugs in an ongoing Phase 2 trial for ad…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: International Multicentric Retrospective Study on the Use of EV+P as First-line Therapy in Patients With la/mUC
An international multicenter retrospective study will evaluate first-line therapy with enfortumab vedotin plus pembrolizumab (EV+P) in local…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers [Phase 1]
Phase 1 exploratory study evaluating FAPi PET/CT imaging with histopathology validation in patients with various cancers. The trial collects…
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CLINICAL_TRIALS research · 2026-01-30Clinical Trial Update: A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer [Phase 2]
Phase 2 study evaluating LAG-3 and PD-1 therapies with or without TIGIT, compared to PD-L1 therapy, in untreated locally advanced/metastatic…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies
This multi-center study aims to characterize the natural history of urothelial cancer and rare genitourinary tract malignancies. The trial i…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Evaluation of Non-Invasive Assays for the Detection of Urothelial Cancer
This clinical trial is evaluating non-invasive assays for detecting urothelial cancer, with recruitment currently ongoing. The study is spon…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Optimal Methods to Characterize ADC Resistance in Solid Tumors and Identify Clinically Useful Biomarkers [Phase 2]
Phase 2 clinical trial focusing on methods to characterize resistance to antibody-drug conjugates in solid tumors and to identify clinically…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: SeqUential GeMcitabine and MITomycin Treatment for Favorable High-Risk Upper Urinary Tract Urothelial Carcinoma [Phase 2]
This is a Phase 2 clinical trial from Rutgers evaluating sequential gemcitabine and mitomycin for favorable high‑risk upper tract urothelial…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: A Genotype-Phenotype Urothelial Cancer Registry
A genotype-phenotype urothelial cancer registry sponsored by Memorial Sloan Kettering Cancer Center; the study is active but not recruiting.
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CLINICAL_TRIALS research · 2025-03-25Clinical Trial Update: Study of Sacituzumab Govitecan (SG) in Japanese Participants With Advanced Solid Tumors [Phase 1, Phase 2]
Phase 1/2 study of Sacituzumab Govitecan in Japanese participants with advanced solid tumors is ongoing, including metastatic triple-negativ…
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CLINICAL_TRIALS research · 2025-03-24Clinical Trial Update: A Study of Real-world Treatment of Adults With Urothelial Cancer in South Korea and Saudi Arabia
A real-world observational study of adults with metastatic urothelial cancer in South Korea and Saudi Arabia; the study status is completed.…
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CLINICAL_TRIALS research · 2025-03-07Clinical Trial Update: The Evaluation of Molecular Markers From PRedittivI DNA of Clinical Outcomes in Patients With UROthelial Tumor
A recruiting clinical trial evaluating molecular markers from predicted DNA to assess clinical outcomes in patients with urothelial cancer.