Unipolar Depression
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Cognitive Enhancement in Unipolar Depression With Yoga [NA]
ClinicalTrials.gov entry noting a recruiting trial evaluating cognitive enhancement in adults with unipolar depression using yoga as the int…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Validation of EmoDTx as a Digital Endpoint for Mood Monitoring in Adult Patients Suffering From Unipolar Depression
The document reports on validating EmoDTx as a digital endpoint for mood monitoring in adults with unipolar depression and major depressive …
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CLINICAL_TRIALS research · 2025-06-12Clinical Trial Update: Mechanism of Action of Electroconvulsive Therapy
A completed clinical trial from Massachusetts General Hospital studying the mechanism of action of electroconvulsive therapy in unipolar and…
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CLINICAL_TRIALS withdrawal · 2025-02-27Clinical Trial Update: Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST) [Phase 1]
A Phase 1 safety and feasibility study of iLAST, an individualized low amplitude seizure therapy, for unipolar depression, has been withdraw…
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CLINICAL_TRIALS trial_result · 2024-08-21Clinical Trial Update: Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder [NA]
A completed clinical trial assessed the efficacy of the LUMINETTE light therapy device in individuals with major depressive disorder. The st…
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CLINICAL_TRIALS trial_result · 2024-04-08Clinical Trial Update: Deep Brain Stimulation for Major Depressive Disorder [NA]
Clinical trial update indicates termination of a deep brain stimulation study for major depressive disorder with results posted.
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CLINICAL_TRIALS trial_result · 2024-01-31Clinical Trial Update: Amitriptyline and Paroxetine Treatment of Major Depression [Phase 3]
Phase 3 clinical trial evaluating amitriptyline and paroxetine treatment for unipolar depression has been completed.
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CLINICAL_TRIALS trial_result · 2023-06-06Clinical Trial Update: tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients [Phase 2]
Phase 2 clinical trial evaluating transcranial direct current stimulation (tDCS) as an add-on treatment for resistant major depression in un…
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CLINICAL_TRIALS trial_result · 2023-03-16Clinical Trial Update: Effects of Erythropoietin on Cognition and Neural Activity in Mood Disorders [Phase 2]
Phase 2 trial evaluating the effects of erythropoietin on cognition and neural activity in mood disorders has completed.
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CLINICAL_TRIALS research · 2023-03-09Clinical Trial Update: Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression [Phase 4]
A Phase 4 clinical trial evaluated ketamine as an augmentation strategy for electroconvulsive therapy (ECT) in unipolar and bipolar depressi…
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CLINICAL_TRIALS trial_result · 2022-06-29Clinical Trial Update: PET and MRI Brain Imaging of Bipolar Disorder [NA]
Clinical trial update reporting completion and posted results for imaging studies in bipolar disorder and bipolar depression.
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CLINICAL_TRIALS trial_result · 2022-05-12Clinical Trial Update: Tracking Depression Symptoms With a Health Chatbot [NA]
Completed clinical trial evaluating a health chatbot for tracking depression symptoms.
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CLINICAL_TRIALS trial_result · 2022-04-06Clinical Trial Update: RCT of Psychoeducational Program of Depression [Phase 2]
Phase 2 randomized trial evaluating a psychoeducational program for unipolar depression has completed.
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CLINICAL_TRIALS research · 2022-03-15Clinical Trial Update: The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. [Phase 4]
A Phase 4 single-arm biomarker development trial evaluating ketamine for non-psychotic unipolar major depression and bipolar depression has …
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CLINICAL_TRIALS trial_result · 2020-01-18Clinical Trial Update: Ketamine as an Adjunctive Therapy for Major Depression [Phase 1]
Phase 1 trial update on ketamine as an adjunctive therapy for major depression; completed with results posted.
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CLINICAL_TRIALS trial_result · 2019-09-10Clinical Trial Update: Improve: Integrating Emotion Focused Components Into Psychological Therapy [Phase 2]
Phase 2 trial update on integrating emotion-focused components into psychological therapy for mood and anxiety disorders; study completed.
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CLINICAL_TRIALS trial_result · 2015-06-02Clinical Trial Update: Risperidone vs. Bupropion ER Augmentation of SSRIs in Treatment-Resistant Depression [Phase 3]
Phase 3 trial comparing risperidone augmentation vs. bupropion ER augmentation of SSRIs in treatment-resistant depression has completed.
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CLINICAL_TRIALS trial_result · 2013-08-02Clinical Trial Update: Paroxetine and Interpersonal Psychotherapy for Maintaining Health and Well-being in Elderly Individuals With Depression [Phase 4]
A Phase 4 clinical trial evaluating paroxetine with interpersonal psychotherapy for maintaining health and well-being in elderly individuals…
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CLINICAL_TRIALS research · 2012-07-04Clinical Trial Update: Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression [Phase 1]
An open Phase 1 study is assessing the feasibility of minocycline in patients with unipolar depression.
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CLINICAL_TRIALS research · 2011-12-06Clinical Trial Update: Validation of the Spanish Version of the Clinically Useful Depression Outcome Scale (CUDOS) Scale
A study validating the Spanish version of the Clinically Useful Depression Outcome Scale (CUDOS) for unipolar depression.