Typhoid Fever
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella Disease and Typhoid Fever in Infants [Phase 2]
A Phase 2 clinical trial evaluating safety, reactogenicity, and immune response of the GVGH iNTS-TCV vaccine aiming to prevent invasive nont…
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: Vellore Typhoid Vaccine Impact Trial [Phase 4]
Phase 4 clinical trial evaluating the Vellore Typhoid Vaccine has completed.
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CLINICAL_TRIALS trial_result · 2026-03-03Clinical Trial Update: This Randomized Controlled Trial Evaluates the Comparative Efficacy of Intravenous Meropenem Alone Versus Intravenous Meropenem Combined With Oral Azithromycin in Children Aged 6 Months to Under 5 Years Diagnosed With Blood Culture-confirmed Extensively Drug-resistant Uncomplicated Typhoid Fever [Phase 4]
Phase 4 randomized trial evaluating whether adding oral azithromycin to intravenous meropenem improves outcomes versus meropenem alone in ch…
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CLINICAL_TRIALS trial_result · 2026-01-15Clinical Trial Update: The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial) [Phase 4]
A Phase 4 trial evaluating azithromycin and cefixime for typhoid fever in South Asia has completed.
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: CVD 37000: Immunity and Microbiome Studies at Intestinal and Systemic Sites in Ty21a Vaccinated Adults [Phase 4]
A Phase 4 clinical trial update studying immunity and microbiome effects at intestinal and systemic sites in adults vaccinated with Ty21a fo…
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CLINICAL_TRIALS trial_result · 2025-12-17Clinical Trial Update: WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study [EARLY_Phase 1]
An early-phase fiber-intervention trial sponsored by USDA's Western Human Nutrition Research Center has completed, evaluating effects on inf…
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella and Typhoid Fever [Phase 1, Phase 2]
A completed Phase 1/2 study evaluated the safety, reactogenicity, and immune response of the GVGH iNTS-TCV vaccine against invasive non-typh…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Induction of Gut Permeability by an Oral Vaccine [EARLY_Phase 1]
Early-phase 1 clinical trial assessing an oral vaccine designed to induce gut permeability; the study is currently active but not recruiting…
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: Efficacy of Levofloxacin Versus Ciprofloxacin in the Treatment of Childhood Typhoid Fever [Phase 2]
Phase 2 trial comparing levofloxacin to ciprofloxacin for treating childhood typhoid fever has completed.
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera [Phase 4]
This clinical trial update describes a Phase 4 study evaluating responses to Typhoid and/or Cholera vaccination, currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Persistence and Long-Term Protection of Vi Antibodies Induced by Vi-DT Conjugate Vaccines in Indonesian [Phase 2, Phase 3]
This update reports completed Phase 2/3 data on the persistence of Vi antibodies and potential long-term protection from the Vi-DT conjugate…
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Long-Term Protection of Vi Antibodies Induced by Bio TCV in Indonesian Population Compared to PQed TCV
This clinical trial update compares long-term Vi antibody protection induced by Bio TCV against PQed TCV in the Indonesian population. The s…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Among Children Age 9 Months Through 12 Years in Blantyre, Malawi [Phase 3]
A Phase 3 clinical trial in Malawi is assessing the efficacy of Typhoid Conjugate Vaccine (Vi-TCV) in children aged 9 months to 12 years; th…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Typhoid Conjugate Vaccine Trial Among Children Younger Than 2 Years in Ouagadougou, Burkina Faso [Phase 2]
A Phase 2 clinical trial of a typhoid conjugate vaccine in children under 2 years in Ouagadougou, Burkina Faso has completed.
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CLINICAL_TRIALS research · 2025-03-05Clinical Trial Update: Diagnosis and Staging of Typhoid Fever Using Surface-enhanced Raman Spectroscopy Liquid Biopsy [NA]
A completed clinical trial evaluated the use of surface-enhanced Raman spectroscopy as a liquid biopsy to diagnose and stage Typhoid fever. …
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CLINICAL_TRIALS research · 2025-03-03Clinical Trial Update: Transcriptomic Responses for the Identification of Pathogens
A University of Sheffield study is recruiting to evaluate transcriptomic responses for identifying pathogens responsible for enteric fever a…
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CLINICAL_TRIALS trial_result · 2025-02-07Clinical Trial Update: ZyVac-TCV Bangladesh Study [Phase 3]
Phase 3 trial of ZyVac-TCV for typhoid vaccination in Bangladesh is currently not recruiting.
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CLINICAL_TRIALS trial_result · 2025-01-24Clinical Trial Update: Safety and Immunogenicity of a Novel Conjugate Vaccine Against Salmonella Typhi and Salmonella Paratyphi A in Healthy Adults [Phase 1]
Phase 1 trial in healthy adults shows safety and immunogenicity of a novel conjugate vaccine targeting Salmonella Typhi and Salmonella Parat…
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CLINICAL_TRIALS trial_result · 2024-12-24Clinical Trial Update: Non-inferiority Trial of Locally Manufactured Typhoid Conjugate Vaccine 'Typhocon' in Bangladesh [Phase 1, Phase 2]
This clinical trial update reports the completion of a non-inferiority Phase 1/2 study in Bangladesh evaluating Typhocon, a locally manufact…
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CLINICAL_TRIALS trial_result · 2024-12-16Clinical Trial Update: Effects of Aging on Primary and Secondary Vaccine Responses [Phase 1]
A completed Phase 1 Stanford study examines how aging affects primary and secondary vaccine responses to vaccines for influenza and hepatiti…
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: Immune Response Elicited by Concomitant Administration of Oral Typhoid Fever (Vivotif®) and Cholera (Dukoral®) Vaccines [Phase 4]
A Phase 4 study evaluating the immune response when the oral typhoid vaccine Vivotif and the cholera vaccine Dukoral are given together, ass…
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CLINICAL_TRIALS trial_result · 2024-03-08Clinical Trial Update: Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana [Phase 4]
A Phase 4 clinical trial evaluating the effectiveness of a typhoid conjugate vaccine in Ghana.
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CLINICAL_TRIALS trial_result · 2023-10-13Clinical Trial Update: Co-administration Study of OCV, TCV and MR [Phase 3]
A Phase 3 clinical trial update on co-administration of OCV, TCV, and MR vaccines is in progress, with typhoid and cholera as conditions und…
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CLINICAL_TRIALS trial_result · 2023-05-06Clinical Trial Update: Understanding Typhoid Disease After Vaccination [Phase 2]
Phase 2 trial update examining typhoid disease after vaccination has been completed.
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CLINICAL_TRIALS trial_result · 2023-04-18Clinical Trial Update: Effectiveness of a Typhoid Conjugate Vaccine in DRC [Phase 4]
Phase 4 clinical trial update evaluating the effectiveness of a typoid conjugate vaccine in the Democratic Republic of the Congo.