Transthyretin Amyloid Cardiomyopathy
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CLINICAL_TRIALS trial_result · 2026-06-09Clinical Trial Update: EPIC-ATTR: A Study to Evaluate the Effect of Eplontersen on the Transthyretin Reduction and Long-term Safety in Chinese Subjects With Transthyretin Amyloid Cardiomyopathy [Phase 3]
Phase 3 trial update for EPIC-ATTR evaluating eplontersen in transthyretin amyloid cardiomyopathy in Chinese subjects.
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis [Phase 3]
A Phase 3 clinical trial investigating Coramitug (NNC6019-0001) for heart failure due to transthyretin amyloid cardiomyopathy is currently r…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: EPIC-ATTR: A Study to Evaluate the Effect of Eplontersen on the Transthyretin Reduction and Long-term Safety in Chinese Subjects With Transthyretin Amyloid Cardiomyopathy [Phase 3]
Phase 3 trial evaluating eplontersen for transthyretin amyloid cardiomyopathy in Chinese subjects; status is active but not recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: EPIC-ATTR: A Study to Evaluate the Effect of Eplontersen on the Transthyretin Reduction and Long-term Safety in Chinese Subjects With Transthyretin Amyloid Cardiomyopathy [Phase 3]
Phase 3 trial update for EPIC-ATTR evaluating eplontersen’s effect on transthyretin reduction and long-term safety in Chinese subjects with …
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Exploratory Study Evaluating the Relevance of [68Ga]Ga-FAPI-46 for Staging and Identifying Progressing Patients With Transthyretin Cardiac Amyloidosis [Phase 2]
A Phase 2 exploratory trial update evaluating the radiotracer [68Ga]Ga-FAPI-46 for staging and identifying progressing patients with transth…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Implementation of Standardized Early Identification and Diagnosis for Transthyretin Amyloidosis (ATTR) in High-Risk Populations [NA]
AstraZeneca is implementing standardized early identification and diagnosis strategies for transthyretin amyloidosis in high-risk population…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Research Study to Look at the Distribution and Effects of Coramitug on Amyloid Deposits in Heart Tissue Using PET/CT Imaging in People With ATTR Amyloidosis. [Phase 1]
Phase 1 clinical trial evaluating the distribution and effects of coramitug on amyloid deposits in heart tissue of people with transthyretin…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: A Study to Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyretin Amyloidosis With Cardiomyopathy Switch From Tafamidis to Acoramidis [Phase 4]
This Phase 4 study sponsored by Bayer investigates changes in blood transthyretin levels when patients with transthyretin amyloid cardiomyop…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Study to Learn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world Setting
A real-world study evaluating acoramidis in patients with transthyretin amyloid cardiomyopathy is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Korean Post-marketing Surveillance Vyndamax® Capsules for the Treatment of Transthyretin Amyloid Cardiomyopathy
A post-marketing surveillance study update for Vyndamax (tafamidis) in Korean patients with transthyretin amyloid cardiomyopathy shows the t…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Retrospective Observational Study of Epidemiology and Outcomes in Transthyretin Amyloid Cardiomyopathy in Germany
Pfizer-sponsored retrospective observational study in Germany on the epidemiology and outcomes of transthyretin amyloid cardiomyopathy (ATTR…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
A non-interventional observational study sponsored by AstraZeneca to collect data on patients with transthyretin amyloidosis, including ATTR…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis [Phase 3]
This clinical trial update indicates that the Phase 3 study CLEOPATTRA evaluating Coramitug (NNC6019-0001) for heart failure due to transthy…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Study of ALXN2220 Versus Placebo in Adults With ATTR-CM [Phase 3]
A Phase 3 trial comparing ALXN2220 to placebo in adults with transthyretin amyloid cardiomyopathy is ongoing but currently not recruiting.
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: 24 Month Open Label Study of the Tolerability and Efficacy of Inotersen in TTR Amyloid Cardiomyopathy Patients [Phase 2]
A 24-month open-label Phase 2 study of inotersen in transthyretin amyloid cardiomyopathy has been terminated. The trial was sponsored by Bri…
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CLINICAL_TRIALS withdrawal · 2026-02-20Clinical Trial Update: ION-682884 in Patients With TTR Amyloid Cardiomyopathy [Phase 2]
A Phase 2 trial of ION-682884 for transthyretin amyloid cardiomyopathy has been withdrawn.
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: ATTR-CM: A Multi-country, Non-interventional Disease Registry
Pfizer is conducting a multi-country, non-interventional registry for transthyretin amyloid cardiomyopathy (ATTR-CM); the study is currently…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: A Research Study to Look at How a New Medicine Called NNC6019-0001 Works and How Safe it is for People Who Have Heart Disease Due to Transthyretin (TTR) Amyloidosis [Phase 2]
This update reports on a Phase 2 study evaluating Novo Nordisk's investigational medicine NNC6019-0001 for safety and effectiveness in trans…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Increased Pacemaker Lower Rate in ATTR Cardiac Amyloidosis [NA]
This clinical trial update reports an observed increase in the lower-rate pacing setting in patients with transthyretin amyloid cardiomyopat…
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: EFICAC-TTR Trial: Exercise and Nutritional Supplementation in Transthyretin Cardiac Amyloidosis [NA]
This clinical trial in transthyretin amyloid cardiomyopathy studies exercise and nutritional supplementation. The study status is not yet re…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Prospective Evaluation of Artificial Intelligence-enabled Screening for Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
A prospective study evaluating artificial intelligence-enabled screening for transthyretin amyloid cardiomyopathy (ATTR-CM). The trial statu…
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CLINICAL_TRIALS trial_result · 2026-01-30Clinical Trial Update: Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM) [Phase 1]
Phase 1 study of NTLA-2001 in hereditary transthyretin amyloidosis with polyneuropathy and transthyretin amyloid cardiomyopathy has complete…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: EPIC-ATTR: A Study to Evaluate the Effect of Eplontersen on the Transthyretin Reduction and Long-term Safety in Chinese Subjects With Transthyretin Amyloid Cardiomyopathy [Phase 3]
Phase 3 study evaluating eplontersen for transthyretin reduction and long-term safety in Chinese subjects with transthyretin amyloid cardiom…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Cardiac Amyloidosis in Patients With Aortic Stenosis
A clinical trial update describes a study evaluating cardiac amyloidosis in patients with aortic stenosis. The study focuses on transthyreti…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Determining the Association of TTR Stabilizing Therapy With Circulating TTR Amyloid Aggregates Over Time in Patients With ATTR-CM: Longitudinal Biomarker Study
Clinical trial update describing a longitudinal biomarker study to determine whether TTR-stabilizing therapy affects circulating TTR amyloid…