Thrombotic Thrombocytopenic Purpura
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EMA approval · 2026-04-09EMA Authorised: Cablivi (Caplacizumab) — Ablynx NV
The EMA authorised Cablivi (caplacizumab) for thrombotic thrombocytopenic purpura and designated it as an orphan medicine.
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura [Phase 3]
A Phase 3 study evaluating TAK-755 for congenital thrombotic thrombocytopenic purpura is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: A Study to Learn More About the Treatment of People With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Who Received Recombinant ADAMTS13 (rADAMTS13) as Part of the Early Access Program
A clinical trial update describing a study to learn more about treating congenital thrombotic thrombocytopenic purpura (cTTP) with recombina…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: A Study of TAK-755 (rADAMTS13) With Little to No Plasma Exchange (PEX) Treatment in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) [Phase 2]
Phase 2 clinical trial update of TAK-755 (recombinant ADAMTS13) evaluating reduced plasma exchange in adults with immune-mediated thrombotic…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: A Study in Children and, Adults With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Treated With Adzynma
Clinical trial update for a study of Adzynma in children and adults with congenital thrombotic thrombocytopenic purpura; the trial is not ye…
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EMA approval · 2026-02-19EMA Authorised: Adzynma (rADAMTS13) — Takeda Manufacturing Austria AG
The European Medicines Agency authorized Adzynma (rADAMTS13) for the treatment of thrombotic thrombocytopenic purpura and granted orphan med…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Efficacy and Safety of Immunosuppression, Caplacizumab and Plasma Infusion Without Therapeutic Plasma Exchange in Immune-mediated Thrombotic Thrombocytopenic Purpura [NA]
A clinical trial evaluating immunosuppression, caplacizumab, and plasma infusion without therapeutic plasma exchange for immune-mediated thr…
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CLINICAL_TRIALS trial_result · 2025-12-30Clinical Trial Update: Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura [Phase 3]
Phase 3 trial evaluating caplacizumab in combination with immunosuppressive therapy without first-line therapeutic plasma exchange in adults…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: A Survey of Recombinant ADAMTS13 in Participants With Congenital Thrombotic Thrombocytopenic Purpura
A clinical trial investigating recombinant ADAMTS13 in participants with congenital thrombotic thrombocytopenic purpura is currently recruit…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
This clinical trial update reports a retrospective epidemiological study of patients in the national cohort of the French TMA Center, examin…
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: Biorepository and Registry for Plasma Exchange Patients
A clinical trial update announcing a biorepository and registry for patients undergoing plasma exchange, with recruiting status and listed i…
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CLINICAL_TRIALS research · 2025-04-25Clinical Trial Update: Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP)
A clinical trial update from University Hospital, Rouen about the immunological aspects of thrombotic thrombocytopenic purpura, currently re…
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: A Study of BAX 930 in Children, Teenagers, and Adults Born With Thrombotic Thrombocytopenic Purpura (TTP) [Phase 3]
This Phase 3 study of BAX 930 in children, teenagers, and adults with thrombotic thrombocytopenic purpura has completed and results have bee…
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CLINICAL_TRIALS approval · 2025-02-24Clinical Trial Update: Expanded Access Program of TAK-755 for Congenital Thrombotic Thrombocytopenic Purpura (cTTP)
Takeda's TAK-755 expanded access program for congenital thrombotic thrombocytopenic purpura has been approved for marketing, enabling broade…
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CLINICAL_TRIALS research · 2024-12-11Clinical Trial Update: Longitudinal Cohort of Thrombosis and Hemostasis Diseases
A longitudinal cohort clinical trial in China studying thrombosis and hemostasis diseases. It is currently recruiting at Peking University P…
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CLINICAL_TRIALS research · 2024-07-10Clinical Trial Update: Italian iTTP Registry
An Italian registry study for thrombotic thrombocytopenic purpura (iTTP) is currently recruiting participants.
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CLINICAL_TRIALS research · 2024-05-29Clinical Trial Update: Spanish-Portuguese Thrombotic Thrombocytopenic Purpura Registry
A Spanish-Portuguese thrombotic thrombocytopenic purpura registry is currently recruiting participants to collect data on the condition.
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CLINICAL_TRIALS trial_result · 2023-08-04Clinical Trial Update: Safety Study of Danazol With Plasma Exchange and Steroids for the Treatment of Thrombotic Thrombocytopenic Purpura (TTP) [Phase 2]
This Phase 2 safety study evaluating danazol in combination with plasma exchange and steroids for thrombotic thrombocytopenic purpura was te…
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CLINICAL_TRIALS trial_result · 2023-05-16Clinical Trial Update: The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP) [Phase 2]
Phase 2 trial update examining the use of rituximab in acute thrombotic thrombocytopenic purpura (TTP) has completed.
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CLINICAL_TRIALS trial_result · 2023-04-28Clinical Trial Update: Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP) [Phase 3]
Phase 3 trial evaluating cyclosporine or corticosteroids as adjuncts to plasma exchange in thrombotic thrombocytopenic purpura has completed…
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CLINICAL_TRIALS trial_result · 2022-10-05Clinical Trial Update: Aspirin for Prophylaxis of TTP [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial evaluating aspirin for prophylaxis of thrombotic thrombocytopenic purpura is not yet recruiting.
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FDA approval · 2022-02-23FDA Approved: CABLIVI — Supplemental Application (Genzyme Corporation)
The FDA approved a supplemental application for CABLIVI (caplacizumab) from Genzyme, authorizing changes to the product labeling.
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CLINICAL_TRIALS trial_result · 2021-10-29Clinical Trial Update: Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care [Phase 3]
Phase 3 trial update investigating magnesium sulfate for thrombotic thrombocytopenic purpura in intensive care.
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CLINICAL_TRIALS trial_result · 2021-08-13Clinical Trial Update: Low Dose Rituximab in Thrombotic Thrombocytopenic Purpura [Phase 2]
Phase 2 clinical trial evaluating low-dose rituximab for thrombotic thrombocytopenic purpura has completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-10-19Clinical Trial Update: Romiplostim, Rituximab and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia [Phase 2]
Phase 2 trial evaluating romiplostim, rituximab, and dexamethasone as frontline treatment for immune thrombocytopenia and thrombotic thrombo…