T-cell Prolymphocytic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Ruxolitinib Maintenance Post-Hematopoietic Stem Cell Transplant T-Cell Lymphoma [Phase 2]
An ongoing Phase 2 study evaluating maintenance therapy with ruxolitinib after hematopoietic stem cell transplant in patients with T-cell ly…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Study of Ruxolitinib and Duvelisib in People With Lymphoma [Phase 1]
A Phase 1 clinical trial evaluating the combination of ruxolitinib and duvelisib in patients with T-cell and NK-cell lymphomas is currently …
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: Phase Ib/II Trial of Cladribine/Ruxolitinib/Venetoclax in Patients With Relapsed/Refractory T-cell Prolymphocytic Leukemia [Phase 1, Phase 2]
This clinical trials entry describes a Phase Ib/II study evaluating a triplet regimen of cladribine, ruxolitinib, and venetoclax in relapsed…
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CLINICAL_TRIALS other · 2025-12-08Clinical Trial Update: Registry of the German CLL Study Group
Ongoing registry study by the German CLL Study Group recruiting participants for trials involving chronic lymphocytic leukemia, small lympho…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Observatory of Prolymphocytic Leukemia T
This is a clinical trial registry entry for an ongoing study on prolymphocytic leukemia of T-cell origin, with recruitment currently ongoing…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: A Study Evaluating APG-115 as a Single Agent or in Combination With APG-2575 in Subjects With R/R T-PLL and NHL [Phase 2]
A Phase 2 clinical trial update indicates Ascentage Pharma is evaluating APG-115 alone or with APG-2575 in relapsed/refractory T-cell prolym…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: Itacitinib With High-dose Posttransplantation Cyclophosphamide in Older Patients [Phase 1]
Phase 1 trial evaluating Itacitinib with high-dose posttransplantation cyclophosphamide in older patients. The study is currently ACTIVE_NOT…
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CLINICAL_TRIALS research · 2025-07-15Clinical Trial Update: Duvelisib and Venetoclax in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma (PTCL) [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating the combination of duvelisib and venetoclax in relapsed or refractory peripheral T-cell lymphoma, w…
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors [Phase 1]
Phase 1 trial of KT-333 in adults with refractory lymphomas and solid tumors reports safety, pharmacokinetics, pharmacodynamics, and prelimi…
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CLINICAL_TRIALS trial_result · 2024-12-12Clinical Trial Update: Fludarabine, Cytarabine, and Pegcrisantaspase for the Treament of Relapsed or Refractory Leukemia [Phase 1]
Phase 1 trial of fludarabine, cytarabine, and pegcrisantaspase for relapsed or refractory leukemias was terminated; the update notes the stu…
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CLINICAL_TRIALS research · 2024-11-12Clinical Trial Update: Sequential CAR-T Cells Therapy for CD5/CD7 Positive T-cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Using CD5/CD7-Specific CAR-T Cells [Phase 1, Phase 2]
An ongoing Phase 1/2 clinical trial evaluating sequential CD5/CD7-specific CAR-T cells for CD5/CD7-positive T-cell malignancies including T-…
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Itacitinib and Alemtuzumab in Treating Patients With T-Cell Prolymphocytic Leukemia [Phase 1]
Phase 1 study evaluating itacitinib with alemtuzumab in recurrent T-cell prolymphocytic leukemia has completed.
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CLINICAL_TRIALS trial_result · 2024-07-18Clinical Trial Update: Letermovir for the Prevention of Cytomegalovirus Reactivation in Patients With Hematological Malignancies Treated With Alemtuzumab [Phase 2]
Phase 2 trial evaluating letermovir for prevention of cytomegalovirus reactivation in patients with hematologic malignancies treated with al…
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CLINICAL_TRIALS trial_result · 2022-12-19Clinical Trial Update: A Study Evaluating the Efficacy of Venetoclax Plus Ibrutinib in Participants With T-cell Prolymphocytic Leukemia [Phase 2]
Phase 2 trial evaluating venetoclax plus ibrutinib in T-cell prolymphocytic leukemia has completed with results posted in 2022.
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CLINICAL_TRIALS trial_result · 2022-04-29Clinical Trial Update: Subcutaneous Recombinant Human IL-15 (s.c. rhIL-15) and Alemtuzumab for People With Refractory or Relapsed Chronic and Acute Adult T-cell Leukemia (ATL) [Phase 1]
Phase 1 trial evaluating subcutaneous recombinant human IL-15 in combination with alemtuzumab for refractory or relapsed adult T-cell leukem…
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CLINICAL_TRIALS trial_result · 2022-01-05Clinical Trial Update: Combined Immunochemotherapy in Patients With T-Prolymphocytic Leukemia (T-PLL) [Phase 2]
Phase 2 trial update evaluating combined immunochemotherapy in patients with T-cell prolymphocytic leukemia (T-PLL) has been completed.
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CLINICAL_TRIALS trial_result · 2019-05-29Clinical Trial Update: Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia [Phase 2]
Phase 2 clinical trial evaluating autologous peripheral blood stem cell transplant followed by donor bone marrow transplant in high-risk B- …
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CLINICAL_TRIALS withdrawal · 2018-05-21Clinical Trial Update: Phase II Study of VELCADE for Relapsed or Refractory T-cell Prolymphocytic Leukemia [Phase 2]
A Phase II trial of Velcade (bortezomib) for relapsed or refractory T-cell prolymphocytic leukemia has been withdrawn (sponsor: Stanford Uni…
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CLINICAL_TRIALS trial_result · 2017-12-08Clinical Trial Update: Fludarabine Phosphate and Total-Body Irradiation Before Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Leukemia [Phase 2]
Phase 2 trial evaluating fludarabine phosphate with total-body irradiation as conditioning before donor peripheral blood stem cell transplan…
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CLINICAL_TRIALS trial_result · 2017-12-07Clinical Trial Update: Autologous Stem Cell Transplant Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoma [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating autologous stem cell transplant followed by donor stem cell transplant in relapsed or refractory lymphom…
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CLINICAL_TRIALS trial_result · 2016-12-06Clinical Trial Update: CAR-pNK Cell Immunotherapy in CD7 Positive Leukemia and Lymphoma [Phase 1, Phase 2]
Phase 1/2 clinical trial update evaluating CAR-pNK cell immunotherapy for CD7-positive leukemias and lymphomas. The available snippet does n…
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CLINICAL_TRIALS trial_result · 2013-07-25Clinical Trial Update: A Study of MK4827 in Participants With Advanced Solid Tumors or Hematologic Malignancies (MK-4827-001 AM8) [Phase 1]
Phase 1 clinical trial update for niraparib (MK-4827) in participants with advanced solid tumors or hematologic malignancies, sponsored by T…