Systemic Sclerosis
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Platform Clinical Study for Conquering Scleroderma [Phase 2]
Phase 2 platform clinical study to conquer systemic sclerosis (scleroderma) is currently recruiting, with a focus on interstitial lung disea…
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: Treatment With Human Umbilical Cord-derived Mesenchymal Stromal Cells in Systemic Sclerosis [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating human umbilical cord-derived mesenchymal stromal cells for systemic sclerosis; currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-02-03Clinical Trial Update: Clinical Study on Targeted CD19CAR-T Therapy for Autoimmune Diseases [EARLY_Phase 1]
A Phase 1 targeted CD19 CAR-T therapy trial for autoimmune diseases has been suspended.
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B Cell Mediated Autoimmune Disease [Phase 1]
Phase 1 clinical trial update for a CAR T-cell therapy targeting CD19 and BCMA in autoimmune conditions, with recruiting status and potentia…
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CLINICAL_TRIALS withdrawal · 2026-02-03Clinical Trial Update: A Study of RD06-04 in Patients With Active Autoimmune Diseases [EARLY_Phase 1]
A early Phase 1 study of RD06-04 in active autoimmune diseases has been withdrawn.
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: Clinical Study on Targeted CD19/BCMA CAR-T Therapy for Autoimmune Diseases [EARLY_Phase 1]
Early-phase clinical study of a targeted CD19/BCMA CAR-T therapy for autoimmune diseases is recruiting, including systemic lupus erythematos…
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CLINICAL_TRIALS research · 2026-01-29Clinical Trial Update: Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
This recruiting study investigates gene expression in cutaneous fibroblasts from patients with systemic sclerosis (scleroderma) to understan…
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: A Study Evaluating the Efficacy and Safety of Baricitinib in Systemic Sclerosis [Phase 4]
A Phase 4 clinical trial is evaluating the efficacy and safety of baricitinib for systemic sclerosis. The study is currently active but not …
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Patient Reported Outcomes With UVA-1 Therapy for Treatment of Sclerosing Skin Diseases [NA]
This entry reports on a clinical trial evaluating patient-reported outcomes of UVA-1 phototherapy for treating sclerosing skin diseases, inc…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Autologous CD19/BCMA Dual-Target CAR-T for Relapsed/Refractory Autoimmune Diseases [Phase 1]
Phase 1 trial evaluating autologous CD19/BCMA dual-target CAR-T therapy for relapsed/refractory autoimmune diseases; currently recruiting at…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Safety and Efficacy of Adipose-Derived Regenerative Cells (ADRCs) for Improving Hand Dysfunction in Systemic Sclerosis [NA]
A clinical trial update indicates ongoing recruitment for assessing the safety and efficacy of adipose-derived regenerative cells (ADRCs) to…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Safety, Efficacy and Cellular Metabolic Dynamics of CT1195E in Patients With Refractory / Progressive SSC [EARLY_Phase 1]
An early Phase 1 trial update for CT1195E in patients with refractory or progressive systemic sclerosis, with recruitment ongoing.
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: CAR T-cell Therapy Targeting CD19 and BCMA(QT-019C) in Patients With Relapse/Refractory Autoimmune Diseases [Phase 1]
A Phase 1 clinical trial evaluating QT-019C, a CD19 and BCMA-targeted CAR T-cell therapy, for relapse/refractory autoimmune diseases; recrui…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Western Sweden Systemic Sclerosis Project
A systemic sclerosis (scleroderma) trial in Western Sweden, sponsored by Sahlgrenska University Hospital, is currently recruiting and evalua…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Familial Systemic Scleroderma
A clinical trial update shows that a study investigating familial systemic sclerosis (systemic scleroderma) is currently recruiting in Stras…
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: the Safety and Efficacy of Targeted BCMA In Vivo LV Injection for Recurrent or Refractory Autoimmune Diseases [EARLY_Phase 1]
An early Phase 1 clinical trial evaluating the safety and efficacy of a targeted BCMA in vivo lentiviral vector injection for recurrent or r…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Longitudinal Spatial Frequency Domain Imaging Study [NA]
Boston University is conducting a longitudinal Spatial Frequency Domain Imaging study for systemic sclerosis (NCT05672992). The trial is cur…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Diffuse Cutaneous Scleroderma (DSSc) SFDI Study [NA]
This clinical trial update notes that the Diffuse Cutaneous Scleroderma SFDI study (NCT07090226) sponsored by Boston University is currently…
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CLINICAL_TRIALS trial_result · 2026-01-13Clinical Trial Update: A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1) [Phase 1]
Phase 1 Breakfree-1 trial evaluating CC-97540, a CD-19-targeted Nex-T CAR T cell therapy, for severe, refractory autoimmune diseases; the st…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease [Phase 2, Phase 3]
Clinical trial update on belimumab for systemic sclerosis-associated interstitial lung disease, spanning Phase 2 and Phase 3, currently recr…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic Sclerosis [Phase 2]
A Phase 2 trial update evaluating the safety and tolerability of TOP-N53 applied to digital ulcers in systemic sclerosis, with recruitment o…
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CLINICAL_TRIALS trial_result · 2026-01-08Clinical Trial Update: Efficacy and Safety of Allogenic Cultured Adipose-derived Mesenchymal Stromal Cell Injections on MoUth Fibrosis and Handicap in Patients With Systemic sclEroderma [Phase 2]
Phase 2 clinical trial evaluating allogeneic cultured adipose-derived mesenchymal stromal cell injections for mouth fibrosis and handicap in…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of Life [NA]
Update on a clinical trial evaluating the Apollo Device for systemic sclerosis, targeting fatigue, Raynaud phenomenon, and quality of life.
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Duke University’s MADRA pregnancy autoimmune disease registry is actively recruiting to study autoimmune conditions during pregnancy, includ…
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EMA approval · 2026-01-06EMA Authorised: Ofev (nintedanib) — Boehringer Ingelheim International GmbH
The European Medicines Agency authorised a label expansion for Ofev (nintedanib) to cover additional interstitial lung diseases, including s…