Systemic Sclerosis
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases. [Phase 2]
Phase 2 trial evaluating AlloNK, an allogeneic cord blood-derived NK cell therapy, in combination with Rituximab for relapsing B-cell–depend…
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CLINICAL_TRIALS research · 2025-12-23Clinical Trial Update: Prevalence of Hyperprolactinemia in Systemic Scleroderma
This completed clinical trial update from University Hospital, Lille evaluates how common hyperprolactinemia is in patients with systemic sc…
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CLINICAL_TRIALS research · 2025-12-23Clinical Trial Update: Profibrosing Role of B Lymphocytes in Patients With Systemic Sclerosis. [NA]
This document provides an update on a clinical trial investigating the profibrotic role of B lymphocytes in patients with systemic sclerosis…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Clinical Study of CD19 CAR-T in the Treatment of Refractory Systemic Sclerosis [Phase 1]
A Phase 1 clinical trial is studying CD19 CAR-T cell therapy for refractory systemic sclerosis (scleroderma). The study is currently recruit…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: A Study of CD19 UCAR-T Cells in Subjects With Autoimmune Diseases [NA]
A clinical trial update evaluating CD19 UCAR-T cell therapy in autoimmune diseases; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Investigating the Effectiveness of the Biopsychosocial Model-Based Exercise Approach in Children and Adults Diagnosed With Scleroderma [NA]
A clinical trial evaluating a biopsychosocial model-based exercise approach for children and adults diagnosed with scleroderma (systemic scl…
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CLINICAL_TRIALS research · 2025-12-09Clinical Trial Update: A Study to Investigate the Long-term Safety and Efficacy of Belimumab in Adults With Interstitial Lung Disease (ILD) Associated With Systemic Sclerosis (SSc) and Other Connective Tissue Diseases (CTD) (BLISSconneCTD-OLE) [Phase 3]
This update outlines a Phase 3 clinical trial evaluating the long-term safety and efficacy of belimumab in adults with interstitial lung dis…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Evaluating Tools to Communicate Scleroderma Research Results to Patients - Trial #1 [NA]
A trial (Trial #1) is evaluating tools to communicate scleroderma research results to patients, sponsored by the Lady Davis Institute. The s…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune Deficiencies
This clinical trial aims to characterize autoreactive B lymphocytes in autoimmune diseases and immune deficiencies. The study status is not …
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis [NA]
A clinical trial is recruiting to evaluate diosmin for the treatment of digital ulcers in systemic sclerosis (scleroderma).
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Interferon Signature in Anti-CTLA-4 and Anti-PD-1/PD-L1-Treated Cancer Patients Compared With Systemic Autoimmune Disease Patients
A recruiting clinical trial examining interferon signature differences between cancer patients treated with anti-CTLA-4 or anti-PD-1/PD-L1 t…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Scleroderma Registry & Repository at the Hospital for Special Surgery
Clinical trial registry update for a Scleroderma (systemic sclerosis) registry and repository at Hospital for Special Surgery; currently rec…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Safety and Efficacy of Itacitinib in Adults With Systemic Sclerosis [Phase 2]
A Phase 2 clinical trial is investigating the safety and efficacy of itacitinib in adults with systemic sclerosis and is currently recruitin…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Multicenter Study on the Development of Pulmonary Arterial Hypertension Screening Models Based on Artificial Intelligence for Patients With Systemic Sclerosis
A multicenter clinical trial is investigating AI-based screening models for detecting pulmonary arterial hypertension in patients with syste…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: A Phase 1 Study of SYNCAR-001 + STK-009 Without Conditioning Chemotherapy (Lymphodepletion) in Subjects With Severe, Refractory Systemic Autoimmune Rheumatic Disease [Phase 1]
Synthekine reports a Phase 1 study of SYNCAR-001 plus STK-009 without lymphodepletion in subjects with severe, refractory systemic autoimmun…
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CLINICAL_TRIALS research · 2025-10-15Clinical Trial Update: Sildenafil for Early Pulmonary Vascular Disease in Scleroderma [Phase 2]
A Phase 2 clinical trial evaluating sildenafil for early pulmonary vascular disease in patients with systemic sclerosis (scleroderma) is cur…
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CLINICAL_TRIALS research · 2025-10-15Clinical Trial Update: Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity [NA]
This document provides an update on a rheumatology-focused clinical trial sponsored by Brigham and Women's Hospital that studies an adaptive…
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases [Phase 2]
Phase 2 autologous stem cell transplantation trial for autoimmune diseases is currently recruiting, including systemic lupus erythematosus a…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: KYSA-5: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Systemic Sclerosis [Phase 1, Phase 2]
This document provides an update on KYSA-5, Kyverna Therapeutics' CD19 CAR T-cell trial for systemic sclerosis, indicating the study remains…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Catestatin as a Novel Biomarker for Cardiovascular and Microvascular Involvement in Systemic Sclerosis
This clinical trial investigates catestatin as a biomarker for cardiovascular and microvascular involvement in systemic sclerosis.
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: A Study of Anti-CD19/BCMA Universal CAR-T Cell Therapy RD06-05 in Patients With Autoimmune Diseases. [EARLY_Phase 1]
Phase 1 study evaluating anti-CD19/BCMA universal CAR-T cell therapy RD06-05 in autoimmune diseases; the trial is currently recruiting.
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: CAR-T Cells in Systemic B Cell Mediated Autoimmune Disease [Phase 1, Phase 2]
Miltenyi Biomedicine is conducting Phase 1/2 trials of CAR-T cell therapy targeting B cells for autoimmune diseases, including systemic lupu…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: CAR T-cell Therapy Targeting CD19 and BCMA in Patients With Relapse/Refractory Autoimmune Diseases [Phase 1]
Phase 1 clinical trial update assessing a dual CD19/BCMA-targeted CAR T-cell therapy for relapse/refractory autoimmune diseases, currently r…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Longitudinal Characterization of Microbial Signature in Systemic Sclerosis Patients
Clinical trial update noting ongoing recruitment for a study that longitudinally characterizes the microbial signature in systemic sclerosis…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Pulmonary Hypertension Screening in Scleroderma
A clinical trial update indicates a study screening for pulmonary hypertension in patients with systemic sclerosis (scleroderma) is not yet …