Systemic Sclerosis
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic Sclerosis [EARLY_Phase 1]
An early-phase trial is evaluating total body irradiation using IMRT and cyclophosphamide prior to stem cell transplant for severe systemic …
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis [Phase 2]
This entry reports a Phase 2 clinical trial evaluating the combination of belimumab and rituximab for diffuse cutaneous systemic sclerosis, …
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Scleroderma: Functional Disability Between the Dominant and Contralateral Hand. [NA]
A completed clinical trial assessing functional disability differences between the dominant and contralateral hand in systemic sclerosis.
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Allogeneic CD19/BCMA-Targeted CAR-γδT Cell Therapy: Safety and Preliminary Pharmacodynamics in Relapsed/Refractory Autoimmune Diseases [Phase 1]
Phase 1 clinical trial update on an allogeneic CD19/BCMA-targeted CAR-γδT cell therapy assessing safety and preliminary pharmacodynamics in …
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Systemic Sclerosis DIet for GastrointESTinal Symptoms [NA]
A recruiting clinical trial at the University of Michigan is evaluating a dietary intervention to manage gastrointestinal symptoms in system…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Double Immunosuppression With or Without Anti-fibrotic in Scleroderma ILD
A clinical trial is evaluating double immunosuppression with or without an anti-fibrotic therapy for systemic sclerosis-associated interstit…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Hand Disability In Systemic Sclerosis - Digital Ulcers
Pamukkale University is conducting a clinical trial on hand disability related to digital ulcers in systemic sclerosis, and the study is cur…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: A Phase 1 Study of Prulacabtagene Leucel (Prula-cel, Formerly ADI-001) in Autoimmune Disease [Phase 1]
Phase 1 trial update for Prulacabtagene Leucel (Prula-cel) in autoimmune diseases, with enrollment by invitation ongoing across indications …
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Hand ScleroDerma Lived Experience Scale in Individuals With Systemic Sclerosis
A clinical trial is evaluating the Hand ScleroDerma Lived Experience Scale in individuals with Systemic Sclerosis to measure hand-related im…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune Diseases
A clinico-biological collection study designed to investigate the pathophysiology of systemic autoimmune diseases, including systemic lupus …
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Clinical Study of EVM18001 in the Treatment of Refractory Autoimmune Diseases [NA]
A clinical trial evaluating EVM18001 for refractory autoimmune diseases is currently recruiting, including systemic lupus erythematosus, sys…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: CT1190B in the Treatment of Patients With Moderate to Severe Refractory Systemic Lupus Erythematosus (SLE) or Refractory/Progressive Systemic Sclerosis (SSc) [Phase 1]
A Phase 1 study evaluating CT1190B for moderate-to-severe refractory systemic lupus erythematosus or refractory/progressive systemic scleros…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease [Phase 1]
Phase 1 study update for FT819 in B-cell–mediated autoimmune diseases; recruitment is ongoing for ANCA-associated vasculitis, idiopathic inf…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Assessment of Nutritional Status in Rheumatic Diseases and Association to Disease Activity
A Cairo University-led study is recruiting to evaluate nutritional status in rheumatic diseases and its association with disease activity ac…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases [EARLY_Phase 1]
An early-phase 1 clinical trial evaluating a targeted CD19 or CD19-BCMA CAR-T therapy for autoimmune diseases is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacaptagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis [Phase 3]
This clinical trial update describes a Phase 3 study evaluating CD19-CAR T cells (Zola-cel/BMS-986353) versus standard of care in active sys…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Faecal Microbiota Transplantation Against Chronic Diarrhea in Patients With Systemic Sclerosis [NA]
A clinical trial update shows ongoing research on fecal microbiota transplantation for chronic diarrhea in patients with systemic sclerosis.…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating CD19-BCMA CAR T cell therapy for refractory lupus nephritis, systemic sclerosis, and primary Sjögren's…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH. [Phase 1, Phase 2]
A Phase 1/2 trial evaluating Umbilical Cord Blood CD19-BCMA CART Cell Therapy for refractory lupus nephritis, systemic sclerosis, and primar…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Exploratory Clinical Study on YTS109 Cell Therapy for Autoimmune Diseases [Phase 1]
A Phase 1 exploratory study evaluating the safety and feasibility of YTS109 cell therapy for multiple autoimmune diseases, currently recruit…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: A Clinical Study of YTS109 Cell for R/R Autoimmune Diseases [Phase 1]
Phase 1 clinical study of YTS109 cell therapy for refractory autoimmune diseases is currently recruiting. The trial will evaluate safety and…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases [EARLY_Phase 1]
An early-phase exploratory clinical study evaluating the safety and potential efficacy of an anti-CD19/BCMA U CAR-T cell therapy for relapse…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Quantification of Calcinosis Cutis Disease Burden Using Computed Tomography Images
A Yale University-led clinical trial is recruiting to quantify calcinosis cutis disease burden in patients with systemic sclerosis using com…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: A Clinical Study of TI-0032-III Injection in Patients With Relapsed and Refractory Autoimmune Diseases [Phase 1]
A Phase 1 clinical trial of TI-0032-III Injection for relapsed and refractory autoimmune diseases is currently recruiting, encompassing seve…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE) [Phase 2]
This document announces a Phase 2 clinical trial evaluating Tibulizumab for systemic sclerosis (scleroderma), which is currently recruiting …