Systemic Mastocytosis
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: (PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis [Phase 2]
Phase 2 PATHFINDER study evaluating avapritinib in advanced systemic mastocytosis and related subtypes has completed with results posted, as…
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis [Phase 2]
Bezuclastinib is being studied in a Phase 2 trial for advanced systemic mastocytosis and related subtypes; recruitment is ongoing.
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocytosis [Phase 3]
Phase 3 trial evaluating denosumab for osteoporosis associated with systemic mastocytosis has completed.
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CLINICAL_TRIALS trial_result · 2026-03-09Clinical Trial Update: Expanded Access to Bezuclastinib for Patients With NonAdvanced Systemic Mastocytosis or Advanced Systemic Mastocytosis
The document reports expanded access for Bezuclastinib to patients with nonadvanced or advanced systemic mastocytosis.
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies [Phase 1]
A Phase 1 trial evaluating flotetuzumab for relapsed or refractory CD123-positive hematologic malignancies has completed, providing initial …
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: Thalidomide in Treating Patients With Relapsed or Progressive Systemic Mastocytosis
A completed clinical trial studied thalidomide for relapsed or progressive systemic mastocytosis. The update does not provide trial results.
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CLINICAL_TRIALS trial_result · 2025-04-10Clinical Trial Update: Study of Elenestinib (BLU-263) in Advanced Systemic Mastocytosis (AdvSM) and and Other KIT Altered Hematologic Malignancies [Phase 1]
Elenestinib (BLU-263) in a Phase 1 study for Advanced Systemic Mastocytosis and KIT-altered hematologic malignancies has been terminated.
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CLINICAL_TRIALS trial_result · 2022-11-10Clinical Trial Update: GTB-3550 Tri-Specific Killer Engager (TriKE®) for High Risk Hematological Malignancies [Phase 1, Phase 2]
Phase 1/2 trial of GTB-3550 Tri-Specific Killer Engager (TriKE) for high-risk hematologic malignancies has been terminated; results posted i…
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CLINICAL_TRIALS trial_result · 2021-06-29Clinical Trial Update: A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies [Phase 1, Phase 2]
A Phase 1/2 study of oral AMN107 (imatinib) in adults with chronic myeloid leukemia and other hematologic malignancies has completed enrollm…
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CLINICAL_TRIALS trial_result · 2019-05-06Clinical Trial Update: Dasatinib as Therapy for Myeloproliferative Disorders (MPDs) [Phase 2]
Phase 2 trial evaluating dasatinib for myeloproliferative disorders; the study has completed and results were posted in 2019.
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CLINICAL_TRIALS trial_result · 2019-01-29Clinical Trial Update: Brentuximab Vedotin in Treating Patients With Advanced Systemic Mastocytosis or Mast Cell Leukemia [Phase 2]
Phase 2 trial evaluating Brentuximab vedotin in advanced systemic mastocytosis or mast cell leukemia has completed and results have been pos…
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CLINICAL_TRIALS trial_result · 2018-09-20Clinical Trial Update: Ibrutinib in Treating Patients With Advanced Systemic Mastocytosis [Phase 2]
Phase 2 trial of ibrutinib in advanced systemic mastocytosis was terminated with posted results in 2018.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Stem Cell Transplantation to Treat Systemic Mastocytosis [Phase 2]
An update on a Phase 2 trial evaluating stem cell transplantation as a treatment for systemic mastocytosis. The study status is listed as co…
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CLINICAL_TRIALS trial_result · 2017-02-23Clinical Trial Update: Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes [Phase 2]
Phase 2 clinical trial evaluating imatinib mesylate in patients with various activated tyrosine kinase-driven malignancies, including hypere…
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CLINICAL_TRIALS trial_result · 2016-09-29Clinical Trial Update: Treatment of Indolent Systemic Mastocytosis With PA101 [Phase 2]
A Phase 2 clinical trial evaluating PA101 for indolent systemic mastocytosis has completed.
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CLINICAL_TRIALS trial_result · 2016-08-29Clinical Trial Update: Imatinib in KIT-negative Systemic Mastocytosis [Phase 4]
The Phase 4 clinical trial evaluating imatinib for KIT-negative systemic mastocytosis has completed. The snippet provides basic trial status…
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CLINICAL_TRIALS trial_result · 2016-08-29Clinical Trial Update: Cladribine Plus Pegylated Interpheron Alfa-2a in Systemic Mastocytosis [Phase 2, Phase 3]
This clinical trial update notes a study evaluating cladribine plus pegylated interferon alfa-2a for systemic mastocytosis in Phase 2 and Ph…
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CLINICAL_TRIALS trial_result · 2015-07-09Clinical Trial Update: Phase 2 Midostaurin in Aggressive Systemic Mastocytosis and Mast Cell Leukemia [Phase 2]
Phase 2 trial update for midostaurin in aggressive systemic mastocytosis and mast cell leukemia has completed with results posted in 2015.
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CLINICAL_TRIALS trial_result · 2012-03-15Clinical Trial Update: 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis [Phase 2]
A Phase 2 clinical trial evaluated tanespimycin (17-N-Allylamino-17-Demethoxygeldanamycin) in patients with systemic mastocytosis; the study…
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CLINICAL_TRIALS trial_result · 2012-02-08Clinical Trial Update: Ontak (Denileukin Diftitox) in Patients With Systemic Mastocytosis (SM) [Phase 2]
Phase 2 clinical trial update for Ontak (denileukin diftitox) in patients with systemic mastocytosis and leukemia. The study status is compl…
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CLINICAL_TRIALS trial_result · 2011-04-29Clinical Trial Update: Everolimus (RAD001) as Therapy for Patients With Systemic Mastocytosis [Phase 2]
Phase 2 trial results update evaluating everolimus (RAD001) as therapy for patients with systemic mastocytosis.
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CLINICAL_TRIALS trial_result · 2011-04-25Clinical Trial Update: Obatoclax for Systemic Mastocytosis [Phase 2]
Phase 2 trial of obatoclax for systemic mastocytosis (with leukemia) was terminated; results were posted in 2011.
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CLINICAL_TRIALS trial_result · 2009-09-18Clinical Trial Update: Evaluation of Response of Dasatinib to Treat Mastocytosis [Phase 2]
A Phase 2 trial is evaluating dasatinib for systemic mastocytosis; the current update provides no results or status details.
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CLINICAL_TRIALS trial_result · 2007-12-13Clinical Trial Update: Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals
This clinical trial update compares cytokine production patterns in patients with systemic mastocytosis to those in individuals with atopic …