Syndrome of Inappropriate Antidiuretic Hormone Secretion
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: Effects of Intravenous [Pyr1]Apelin-13 on Healthy Volunteers With Artificially Induced SIAD [NA]
A completed clinical trial evaluating intravenous [Pyr1]Apelin-13 in healthy volunteers with artificially induced SIAD, focusing on effects …
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CLINICAL_TRIALS trial_result · 2025-03-28Clinical Trial Update: Asymptomatic Bacteriuria, Hyponatremia and Geri-atric Syndrome [NA]
This is a completed clinical trial update from Universitair Ziekenhuis Brussel examining asymptomatic bacteriuria in the context of hyponatr…
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CLINICAL_TRIALS trial_result · 2025-03-24Clinical Trial Update: Samsca Post-marketing General Drug Use-results Survey in Patients with Hyponatremia in SIADH
This clinical trial update discusses a post-marketing general drug use-results survey evaluating tolvaptan (Samsca) for hyponatremia associa…
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CLINICAL_TRIALS trial_result · 2024-05-20Clinical Trial Update: Urea for Chronic Hyponatremia [Phase 2]
Phase 2 trial evaluating urea for chronic hyponatremia was terminated. Results were posted on 2024-05-20.
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CLINICAL_TRIALS trial_result · 2020-11-02Clinical Trial Update: A Multicenter Trial to Investigate the Efficacy and Safety of Tolvaptan in Patients With Hyponatremia in SIADH [Phase 3]
Phase 3 multicenter trial evaluating tolvaptan for hyponatremia due to SIADH; study completed with results posted.
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CLINICAL_TRIALS trial_result · 2018-04-04Clinical Trial Update: An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy
An observational study conducted in Italy assessed outcomes for cancer patients treated for moderate to severe hyponatremia (often due to SI…
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CLINICAL_TRIALS trial_result · 2018-02-05Clinical Trial Update: An Observational Study on Real-world Use and Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to SIADH
An observational real-world study evaluated outcomes in patients treated with tolvaptan for hyponatremia due to SIADH, with results posted i…
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CLINICAL_TRIALS trial_result · 2016-08-10Clinical Trial Update: Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study [Phase 2, Phase 3]
A completed Phase 2/3 clinical trial (the DIVE study) evaluated the effects of empagliflozin, an SGLT2 inhibitor, in healthy volunteers with…
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CLINICAL_TRIALS trial_result · 2016-05-26Clinical Trial Update: A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia [Phase 3]
A Phase III study evaluating satavaptan versus placebo in patients with dilutional hyponatremia was terminated.
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CLINICAL_TRIALS trial_result · 2016-05-16Clinical Trial Update: A PK Study of 3 Dosages of Tolvaptan in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) [Phase 1, Phase 2]
A pharmacokinetic study evaluating three Tolvaptan dose levels in patients with SIADH was completed (Phase 1/2) with results posted.
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CLINICAL_TRIALS trial_result · 2014-10-17Clinical Trial Update: Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia [Phase 3]
Phase 3 trial evaluating tolvaptan versus fluid restriction in hospitalized patients with dilutional hyponatremia was terminated; results we…
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CLINICAL_TRIALS trial_result · 2012-05-03Clinical Trial Update: "SALT-2 Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia [Phase 3]
Phase 3 SALT-2 trial evaluating ascending doses of tolvaptan for hyponatremia has completed.
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CLINICAL_TRIALS trial_result · 2012-01-12Clinical Trial Update: The Clinical and Laboratory Characteristics of Recurrent Drug- Related Hyponatremia
This clinical trial update describes the clinical and laboratory characteristics of recurrent drug-related hyponatremia, including hyponatre…
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CLINICAL_TRIALS trial_result · 2009-01-21Clinical Trial Update: Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion [Phase 3]
Phase 3 clinical trial evaluating the safety and efficacy of SR121463B in patients with Syndrome of inappropriate antidiuretic hormone secre…
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CLINICAL_TRIALS trial_result · 2008-12-10Clinical Trial Update: Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion [Phase 3]
Phase 3 trial evaluating the efficacy and safety of SR121463B in patients with syndrome of inappropriate antidiuretic hormone secretion (SIA…
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CLINICAL_TRIALS trial_result · 2008-06-17Clinical Trial Update: Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion [Phase 2]
Phase 2 trial evaluating the efficacy of SR121463B in Syndrome of inappropriate antidiuretic hormone secretion and hyponatremia has complete…
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CLINICAL_TRIALS trial_result · 2007-01-26Clinical Trial Update: "SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia [Phase 3]
The SALT trial, a Phase 3 study evaluating escalating doses of tolvaptan for hyponatremia, has completed.