Squamous Cell Carcinoma of the Lung
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-06-13Clinical Trial Update: A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands [Phase 1]
Phase 1 clinical trial update of LGK974, a Wnt pathway inhibitor, in malignancies dependent on Wnt ligands; the study included several cance…
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CLINICAL_TRIALS research · 2025-06-08Clinical Trial Update: Phase II Study of Platinum (Cisplatin/Carboplatin)and Polymeric Micelles Paclitaxel(Pm-Pac) With Ivonescimab in First Line Metastatic Squamous NSCLC. [Phase 2]
Phase II trial evaluating first-line treatment of metastatic squamous non-small cell lung cancer with cisplatin/carboplatin, polymeric micel…
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors. [Phase 1]
Pfizer's Phase 1 study of PF-06940434 in advanced or metastatic solid tumors has been terminated. The trial enrolled several solid tumor typ…
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CLINICAL_TRIALS research · 2025-05-21Clinical Trial Update: National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer [Phase 2]
This entry covers the National Lung Matrix Trial, a multi-drug Phase II study in non-small cell lung cancer, with the trial currently active…
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CLINICAL_TRIALS trial_result · 2025-04-24Clinical Trial Update: A Study of Sapanisertib in Relapsed/Refractory NFE2L2-Mutated and Wild-Type Squamous Non-Small Cell Lung Cancer [Phase 2]
Phase 2 trial of sapanisertib in relapsed/refractory squamous non-small cell lung cancer (including NFE2L2-mutant and wild-type) has been te…
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CLINICAL_TRIALS trial_result · 2025-04-23Clinical Trial Update: Bispecific PSMAxCD3 Antibody CC-1 in Patients With Squamous Cell Carcinoma of the Lung [Phase 1, Phase 2]
A phase 1/2 trial of the bispecific PSMAxCD3 antibody CC-1 in squamous cell carcinoma of the lung has been terminated.
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CLINICAL_TRIALS trial_result · 2025-03-25Clinical Trial Update: A Study of Bemarituzumab Monotherapy and Combination With Other Anti-cancer Therapy in SqNSCLC With FGFR2b Overexpression (FORTITUDE-201) [Phase 1]
Fortitude-201 (bemarituzumab) is a Phase 1 trial evaluating bemarituzumab alone or in combination with other anti-cancer therapies in FGFR2b…
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CLINICAL_TRIALS research · 2025-01-13Clinical Trial Update: To Evaluate the Efficacy and Safety of Inhaled Corticosteroids Combined With Bronchodilators and Programmed Death-ligand 1 (PD-L1) Inhibitor Plus Platinum-based Chemotherapy in Patients With Advanced Lung Squamous Cell Carcinoma Complicated With Chronic Obstructive Pulmonary Disease (COPD)
A clinical trial is evaluating whether adding inhaled corticosteroids and bronchodilators to a PD-L1 inhibitor plus platinum-based chemother…
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CLINICAL_TRIALS withdrawal · 2024-12-10Clinical Trial Update: Neoadjuvant Nimotuzumab Plus Gemcitabine and Carboplatin in Unresectable Stage III Squamous Cell Lung Carcinoma [Phase 2]
A Phase 2 neoadjuvant trial of nimotuzumab with gemcitabine and carboplatin for unresectable Stage III squamous cell lung carcinoma has been…
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CLINICAL_TRIALS trial_result · 2024-11-06Clinical Trial Update: A Study of Pembrolizumab (MK-3475) With or Without Maintenance Olaparib in First-line Metastatic Squamous Non-small Cell Lung Cancer (NSCLC, MK-7339-008/KEYLYNK-008) [Phase 3]
A Phase 3 study evaluating pembrolizumab with or without maintenance olaparib as first-line treatment in metastatic squamous non-small cell …
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CLINICAL_TRIALS research · 2024-09-20Clinical Trial Update: ALK Tyrosine Kinase Inhibitors in ALK-rearranged Advanced Squamous Cell Carcinoma [Phase 2]
This clinical trial is evaluating ALK tyrosine kinase inhibitors in ALK-rearranged advanced squamous cell carcinoma (a form of non-small cel…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Real-World Effectiveness of Afatinib (Gilotrif) Following Immunotherapy in the Treatment of Metastatic, Squamous Cell Carcinoma of the Lung: A Multi-Site Retrospective Chart Review Study in the U.S.
A multi-site retrospective chart review assessing real-world effectiveness of afatinib following immunotherapy in patients with metastatic s…
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CLINICAL_TRIALS research · 2024-07-18Clinical Trial Update: Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated NSCLC Patients
An ongoing clinical study is investigating therapeutic resistance and clonal evolution in non-small cell lung cancer patients treated with i…
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CLINICAL_TRIALS research · 2024-06-25Clinical Trial Update: GPC3-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression [Phase 1]
Phase 1 trial evaluating GPC3-CAR-T cell therapy for glypican-3 expressing cancers. The study includes hepatocellular carcinoma and squamous…
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CLINICAL_TRIALS trial_result · 2024-06-04Clinical Trial Update: Study of ADXS-503 With or Without Pembro in Subjects With Metastatic Non-Small Cell Lung Cancer [Phase 1, Phase 2]
Clinical trial update reports completion and posted results for ADXS-503 with or without pembrolizumab in metastatic non-small cell lung can…
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CLINICAL_TRIALS trial_result · 2024-03-29Clinical Trial Update: Tipifarnib in Advanced Squamous NSCLC With Oncogen HRAS MutAtionS [Phase 2]
Phase 2 trial of tipifarnib in advanced squamous non-small cell lung cancer with HRAS mutations has been terminated; results were posted in …
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CLINICAL_TRIALS trial_result · 2024-01-10Clinical Trial Update: AZD1775 Plus Carboplatin-Paclitaxel in Squamous Cell Lung Cancer [Phase 2]
Phase 2 trial of AZD1775 in combination with carboplatin and paclitaxel for squamous cell carcinoma of the lung has completed and results ha…
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CLINICAL_TRIALS trial_result · 2023-11-24Clinical Trial Update: Efficacy and Safety Study of Gefitinib in Squamous NSCLC Patients Who Failed First-Line Chemotherapy [Phase 2]
Phase 2 trial evaluating gefitinib for squamous cell carcinoma of the bronchus after failure of first-line chemotherapy; study completed.
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CLINICAL_TRIALS trial_result · 2023-02-14Clinical Trial Update: TQB2450 Injection Combined With Chemotherapy Followed by Sequential Combination With Anlotinib Hydrochloride Capsule for First-line Treatment of Advanced Squamous Non-small Cell Lung Cancer. [Phase 3]
Phase 3 trial evaluating TQB2450 with chemotherapy followed by anlotinib for first-line treatment of advanced squamous non-small cell lung c…
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CLINICAL_TRIALS trial_result · 2023-01-31Clinical Trial Update: Lung-MAP: Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer
A completed clinical trial update for Lung-MAP exploring biomarker-targeted second-line therapy in recurrent stage IV squamous cell lung can…
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CLINICAL_TRIALS trial_result · 2022-02-17Clinical Trial Update: Envafolimab Combined With Chemotherapy and Recombinant Human Endostatin in the First-line Treatment of Sq-NSCLC [Phase 2]
A Phase 2 trial exploring Envafolimab with chemotherapy and recombinant human endostatin as first-line treatment for squamous non-small cell…
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CLINICAL_TRIALS trial_result · 2022-01-21Clinical Trial Update: Durvalumab and Tremelimumab in Treating Patients With Recurrent Stage IV Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating durvalumab and tremelimumab in recurrent stage IV squamous cell lung carcinoma has completed with results …
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CLINICAL_TRIALS trial_result · 2022-01-11Clinical Trial Update: Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers [Phase 3]
Phase 3 Lung-MAP trial update evaluating nivolumab with or without ipilimumab as second-line therapy for recurrent Stage IV squamous cell ca…
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CLINICAL_TRIALS trial_result · 2021-11-24Clinical Trial Update: KN046 in Subjects With Advanced Squamous Non-small Cell Lung Cancer [Phase 3]
Phase 3 trial update for KN046 in subjects with squamous non-small cell lung cancer.
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CLINICAL_TRIALS trial_result · 2021-10-20Clinical Trial Update: A Study of Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With First Line Metastatic Squamous Non-small Cell Lung Cancer (MK-3475-407/KEYNOTE-407)-China Extension Study [Phase 3]
Phase 3 China extension study evaluating pembrolizumab added to carboplatin-paclitaxel or nab-paclitaxel as first-line therapy for metastati…