Squamous Cell Carcinoma of the Head and Neck
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CLINICAL_TRIALS trial_result · 2025-03-24Clinical Trial Update: A Study of NG-641 and Pembrolizumab in Squamous Cell Carcinoma of the Head and Neck [Phase 1]
A Phase 1 study evaluating NG-641 in combination with pembrolizumab for squamous cell carcinoma of the head and neck has completed.
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CLINICAL_TRIALS trial_result · 2025-03-14Clinical Trial Update: SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas [Phase 1]
Phase 1 trial evaluating SL-279252, a PD-1-Fc-OX40L fusion protein, in adults with advanced solid tumors or lymphomas has been completed wit…
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CLINICAL_TRIALS trial_result · 2025-02-28Clinical Trial Update: 1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck [Phase 2]
Phase 2 clinical trial evaluating pembrolizumab in combination with bavituximab for squamous cell carcinoma of the head and neck; results po…
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CLINICAL_TRIALS research · 2025-02-26Clinical Trial Update: Fluorescence-guided Surgery Using cRGD-ZW800-1 in Oral Cancer [Phase 2]
This clinical trial update reports on a Phase 2 study evaluating cRGD-ZW800-1 for fluorescence-guided surgery in oral cancer, including head…
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CLINICAL_TRIALS trial_result · 2025-02-24Clinical Trial Update: Ph1 Study of SL-172154 Administered Intratumorally in Subjects With Squamous Cell Carcinoma of the Head and Neck or Skin [Phase 1]
Phase 1 intratumoral study of SL-172154 in cutaneous squamous cell carcinoma and squamous cell carcinoma of the head and neck was terminated…
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CLINICAL_TRIALS research · 2025-02-13Clinical Trial Update: A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies [Phase 1, Phase 2]
This document reports a Phase 1/Phase 2 clinical trial evaluating GV20-0251 as monotherapy and in combination with pembrolizumab in several …
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CLINICAL_TRIALS research · 2025-01-28Clinical Trial Update: Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck [Phase 2]
A Phase 2 clinical trial is evaluating preoperative immunotherapy in patients with squamous cell carcinoma of the head and neck. The study i…
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CLINICAL_TRIALS trial_result · 2024-12-20Clinical Trial Update: Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL) [Phase 2]
A Phase 2 trial (VolATIL) evaluating UCPVax vaccine in combination with atezolizumab for HPV-positive cancers has completed.
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CLINICAL_TRIALS research · 2024-11-21Clinical Trial Update: Prognostic Counselling in Palliative Head and Neck Cancer (ProCoPall) [NA]
Active-not-recruiting clinical trial at Erasmus Medical Center studying prognostic counselling for patients with head and neck squamous cell…
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CLINICAL_TRIALS research · 2024-11-15Clinical Trial Update: Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067 [Phase 1, Phase 2]
Phase 1a/Phase 2 study evaluating safety, preliminary efficacy, PK and PD of ST-067 in various cancers; currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-11-05Clinical Trial Update: First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours [Phase 1]
This clinical trial update reports the completion of a first-in-human Phase 1 study evaluating AZD8701 with or without durvalumab in adults …
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CLINICAL_TRIALS trial_result · 2024-11-04Clinical Trial Update: Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1 [Phase 1]
Phase 1 study of MT-6402 in PD-L1-expressing advanced solid tumors, including non-small cell lung cancer and squamous cell carcinoma of the …
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CLINICAL_TRIALS trial_result · 2024-11-01Clinical Trial Update: Study of MT-8421 as Monotherapy and in Combination With Nivolumab in Patients With Selected Advanced Solid Cancer Types [Phase 1]
A Phase 1 study evaluating MT-8421 as monotherapy and in combination with nivolumab in selected advanced solid tumors has been terminated. T…
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: A Study of Atezolizumab (Anti-PD-L1 Antibody) as Adjuvant Therapy After Definitive Local Therapy in Patients With High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck [Phase 3]
A Phase 3 trial evaluating atezolizumab as adjuvant therapy after definitive local therapy in high-risk locally advanced squamous cell carci…
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CLINICAL_TRIALS research · 2024-09-20Clinical Trial Update: European Larynx Organ Preservation Study (ELOS) [MK-3475-C44] [Phase 2]
Phase 2 European Larynx Organ Preservation Study (ELOS) evaluates pembrolizumab (MK-3475) for organ-preserving treatment in squamous cell ca…
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CLINICAL_TRIALS other · 2024-08-20Clinical Trial Update: A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer [Phase 1, Phase 2]
This entry describes a Phase I/II clinical trial of UCB4594 for multiple advanced solid tumors, including head and neck squamous cell carcin…
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CLINICAL_TRIALS trial_result · 2024-08-16Clinical Trial Update: ASP-1929 Photoimmunotherapy (PIT) Study in Patients With Recurrent Head/Neck Cancer [Phase 2]
Phase 2 clinical trial update for ASP-1929 Photoimmunotherapy in recurrent head and neck cancer indicates the study is active but not curren…
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CLINICAL_TRIALS research · 2024-08-02Clinical Trial Update: Milaberon in Advanced Solid Tumors: an Open, Multicenter Clinical Study [Phase 2]
Open-phase 2 multicenter trial evaluating Milaberon in advanced solid tumors across multiple indications, currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-07-29Clinical Trial Update: Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors [Phase 1]
Phase 1 study of PF-07209960 in advanced or metastatic solid tumors was terminated, with results posted in July 2024.
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CLINICAL_TRIALS trial_result · 2024-07-11Clinical Trial Update: Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutations [Phase 2]
This entry reports the completion of a Phase II trial of tipifarnib in HRAS-mutant squamous cell carcinoma of the head and neck, with result…
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CLINICAL_TRIALS withdrawal · 2024-07-03Clinical Trial Update: ASTX727 and Nivolumab in Squamous Cell Carcinoma of the Head and Neck [Phase 1]
A Phase 1 trial evaluating ASTX727 in combination with nivolumab for recurrent or metastatic squamous cell carcinoma of the head and neck ha…
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CLINICAL_TRIALS trial_result · 2024-05-24Clinical Trial Update: A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies [Phase 1]
This Phase 1 trial evaluated the safety and tolerability of immunotherapy combinations across multiple advanced cancers and has completed.
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CLINICAL_TRIALS research · 2024-04-25Clinical Trial Update: Window of Opportunity Study of Preoperative Immunotherapy With Atezolizumab in Local SCCHN [Phase 2]
Phase 2 window-of-opportunity trial evaluating preoperative atezolizumab in localized head and neck squamous cell carcinoma has completed.
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CLINICAL_TRIALS trial_result · 2024-04-22Clinical Trial Update: FRAIL-IMMUNE (GORTEC 2018-03) - Combination of Durvalumab With Carboplatin/Paclitaxel [Phase 2]
Phase 2 trial of durvalumab combined with Carboplatin/Paclitaxel in squamous cell carcinoma of the head and neck has completed.
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CLINICAL_TRIALS trial_result · 2024-03-05Clinical Trial Update: A Randomized, Double-blind Study to Evaluate the Clinical Effect and Safety of Fucoidan in Patients With Squamous Cell Carcinomas of the Head and Neck [Phase 2]
A phase 2 randomized, double-blind trial evaluating fucoidan for efficacy and safety in patients with squamous cell carcinomas of the head a…