Squamous Cell Carcinoma of the Head and Neck
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Multimodal Prediction of Response to Chemoradiotherapy for Squamous Cell Carcinoma of the Head and Neck [NA]
This clinical trial update describes a multimodal approach to predict response to chemoradiotherapy in squamous cell carcinoma of the head a…
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies [Phase 1]
A Phase 1 study of JANX008 in advanced or metastatic solid tumors is currently recruiting, evaluating multiple indications including Non-Sma…
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX) [Phase 3]
Phase 3 trial evaluating Xevinapant in combination with platinum-based chemotherapy and radiotherapy for locally advanced squamous cell carc…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study [Phase 2]
This clinical trial update describes a Phase II randomized, double-blind study evaluating adjuvant pembrolizumab versus placebo in head and …
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction [Phase 1]
Phase 1 study evaluating the safety of a single administration of the AAV2hAQP1 gene therapy to the parotid gland in patients with irradiati…
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CLINICAL_TRIALS trial_result · 2025-09-17Clinical Trial Update: A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors [Phase 1]
Pfizer's PF-07820435 study in advanced solid tumors, including non-small-cell lung cancer and other indications, has been terminated at Phas…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Modi-1 Moditope in Breast, Head and Neck, Ovarian, or Renal Cancer [Phase 1, Phase 2]
Scancell's Modi-1 Moditope is being studied in Phase 1/2 trials across several cancers, including triple-negative breast cancer, renal cell …
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CLINICAL_TRIALS trial_result · 2025-09-15Clinical Trial Update: A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer) [Phase 1, Phase 2]
A Phase 1/2 study evaluating multiple treatment combinations in locally advanced squamous cell carcinoma of the head and neck has completed,…
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CLINICAL_TRIALS trial_result · 2025-09-12Clinical Trial Update: Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors [Phase 1]
Phase 1a/1b study of TPST-1495 as monotherapy and in combination with pembrolizumab has completed status, spanning multiple solid tumors inc…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: A Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid Tumors [Phase 1]
Phase 1 trial update evaluating AB248 alone or with pembrolizumab in adults with solid tumors, including non-small cell lung cancer, melanom…
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CLINICAL_TRIALS trial_result · 2025-09-04Clinical Trial Update: A Study of TAK-676 With Pembrolizumab After Radiation Therapy to Treat a Number of Cancers [Phase 1]
Phase 1 trial evaluating TAK-676 in combination with pembrolizumab after radiation therapy across several cancers; the study completed and p…
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: Study of INCA 0186 in Subjects With Advanced Solid Tumors [Phase 1]
A Phase 1 study of INCA 0186 in patients with advanced solid tumors, including squamous cell carcinoma of the head and neck, has been termin…
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CLINICAL_TRIALS trial_result · 2025-07-20Clinical Trial Update: Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN [Phase 2]
Phase 2 trial evaluating durvalumab with radiotherapy as adjuvant treatment for intermediate-risk squamous cell carcinoma of the head and ne…
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors [Phase 1]
A Phase 1 trial of INCB106385, alone or with immunotherapy, in advanced solid tumors has completed. The study includes multiple indications …
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma [Phase 1]
Phase 1 study evaluating radiotherapy with durvalumab before surgical resection for HPV-negative squamous cell carcinoma of the head and nec…
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CLINICAL_TRIALS trial_result · 2025-06-26Clinical Trial Update: Avelumab With Valproic Acid in Virus-associated Cancer [Phase 2]
Phase 2 trial evaluating the PD-L1 inhibitor avelumab in combination with valproic acid for virus-associated cancers has completed; the upda…
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors [Phase 2]
A Phase 2 clinical trial by Iovance Biotherapeutics evaluating autologous tumor-infiltrating lymphocytes in solid tumors is currently recrui…
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Observational Study of Nivolumab in Participants in Germany With Squamous Cell Carcinoma of the Head and Neck (SCCHN) Progressing on or After Platinum-Based Therapy
This clinical trial update reports the completion of an observational study in Germany evaluating nivolumab in patients with squamous cell c…
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CLINICAL_TRIALS research · 2025-06-06Clinical Trial Update: Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck [Phase 2]
This is a Phase 2 clinical trial update examining nivolumab in combination with BMS986205 for stage II-IV squamous cell cancers of the head …
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Margin-Based Vs. Robust Photon Radiotherapy Planning in IMRT of HN-SQCC [NA]
A completed clinical trial comparing margin-based and robust photon radiotherapy planning for IMRT in head and neck squamous cell carcinoma;…
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors. [Phase 1]
Pfizer's Phase 1 study of PF-06940434 in advanced or metastatic solid tumors has been terminated. The trial enrolled several solid tumor typ…
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CLINICAL_TRIALS trial_result · 2025-04-06Clinical Trial Update: Priming Immunotherapy in Advanced Disease With Radiation [Phase 2]
This is a Phase 2 clinical trial update evaluating priming immunotherapy in combination with radiation for advanced disease. Results have be…
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CLINICAL_TRIALS trial_result · 2025-04-04Clinical Trial Update: Study of XB002 in Subjects With Solid Tumors (JEWEL-101) [Phase 1]
JEWEL-101 is a Phase 1 trial of XB002 in patients with solid tumors, covering multiple indications. The study has completed.
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CLINICAL_TRIALS research · 2025-04-01Clinical Trial Update: Safety and Efficacy Trial of TV5M01 for Radiation-Induced Mucositis in Head and Neck Cancer Patients. [Phase 1, Phase 2]
Clinical trial update describing a Phase 1/2 study of TV5M01 for radiation-induced mucositis in head and neck cancer patients, with recruitm…
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: Study of the Effects of Pembrolizumab in Patients With Advanced Solid Tumors [Phase 2]
Phase 2 study evaluating pembrolizumab in patients with advanced solid tumors, including squamous cell carcinoma of the head and neck, tripl…