Single-ventricle Physiology

• CLINICAL_TRIALS research · 2026-04-22
  Clinical Trial Update: Venous Compression in Fontan [NA]

  A clinical trial update describing a study of venous compression in Fontan circulation for individuals with single-ventricle physiology; the…

• CLINICAL_TRIALS research · 2024-12-11
  Clinical Trial Update: ET1 Concentration, Metabolic Pathway Activation, and Pulmonary Blood Flow in Infants Undergoing Superior Cavo-Pulmonary Anastomosis

  A clinical trial evaluates endothelin-1 concentration, metabolic pathway activation, and pulmonary blood flow in infants undergoing superior…

• CLINICAL_TRIALS withdrawal · 2023-05-15
  Clinical Trial Update: Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Disease [Phase 3]

  Phase 3 trial evaluating PDE5 inhibitors in single-ventricle patients with pulmonary hypertension was withdrawn.

• CLINICAL_TRIALS trial_result · 2018-05-18
  Clinical Trial Update: Aspirin as a Novel Anti-Inflammatory Modality in the Fontan Patients [Phase 4]

  Phase 4 trial evaluating aspirin as an anti-inflammatory treatment in Fontan patients was terminated; results were posted in 2018.

• CLINICAL_TRIALS trial_result · 2017-04-18
  Clinical Trial Update: Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle Physiology [NA]

  Clinical trial evaluating whether early intervention reduces maternal stress in pregnancies affected by single-ventricle congenital heart di…

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• CLINICAL_TRIALS trial_result · 2011-06-27
  Clinical Trial Update: Comparison of Two Types of Shunts in Infants With Single Ventricle Defect Undergoing Staged Reconstruction--Pediatric Heart Network [NA]

  The Pediatric Heart Network completed a trial comparing two shunt types in infants with single-ventricle physiology undergoing staged recons…