Single-ventricle Heart Disease

• CLINICAL_TRIALS research · 2026-04-15
  Clinical Trial Update: Occlutech AFR Fontan Study

  This is a clinical trial registration for the Occlutech AFR Fontan study investigating a device-related approach for Fontan-type circulation…

• CLINICAL_TRIALS research · 2026-01-05
  Clinical Trial Update: REHAB Fontan Failure: A Trial of Cardiac Rehabilitation [NA]

  The REHAB Fontan Failure trial is evaluating cardiac rehabilitation for Fontan patients with heart failure related to single-ventricle physi…

• CLINICAL_TRIALS trial_result · 2025-12-09
  Clinical Trial Update: A Extension Study of Udenafil in Adolescents [Phase 3]

  An extension study of udenafil in adolescents with single ventricle heart disease has completed Phase 3 and posted results.

• CLINICAL_TRIALS research · 2025-10-28
  Clinical Trial Update: Fontan Udenafil Exercise Longitudinal Assessment Trial - 2 [Phase 3]

  Phase 3 trial update for Fontan Udenafil Exercise Longitudinal Assessment Trial-2 evaluating udenafil in single ventricle heart disease; rec…

• CLINICAL_TRIALS research · 2025-10-02
  Clinical Trial Update: CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation [Phase 2]

  Phase 2 trial of dapagliflozin in patients with failing Fontan circulation is currently recruiting. The study also considers effects in sing…

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• CLINICAL_TRIALS trial_result · 2025-09-18
  Clinical Trial Update: Evaluation of Fontan-associated Hepatic Stiffness and the Efficacy of Udenafil in Reducing Liver Stiffness [Phase 3]

  Phase 3 trial evaluating whether udenafil can reduce liver stiffness in Fontan-associated liver disease in patients with single-ventricle he…

• CLINICAL_TRIALS research · 2025-07-18
  Clinical Trial Update: Transcatheter Fontan Stenting: Impact on Hepatic Stiffness and Exercise Capacity

  This clinical trial update reports on a study evaluating transcatheter Fontan stenting and its impact on hepatic stiffness and exercise capa…

• CLINICAL_TRIALS research · 2025-06-17
  Clinical Trial Update: NIRS in Congenital Heart Defects - Correlation With Echocardiography

  Clinical trial update on a McGill-led study assessing near-infrared spectroscopy (NIRS) in congenital heart defects and its correlation with…

• CLINICAL_TRIALS trial_result · 2025-05-21
  Clinical Trial Update: Fontan Udenafil Exercise Longitudinal Assessment Trial [Phase 3]

  Phase 3 Fontan udenafil exercise longitudinal assessment trial in single-ventricle heart disease has completed and results have been posted.…

• CLINICAL_TRIALS trial_result · 2025-05-06
  Clinical Trial Update: Pharmacokinetic/Pharmacodynamic Study of Udenafil in Adolescents [Phase 1, Phase 2]

  Results from a Phase 1/Phase 2 pharmacokinetic/pharmacodynamic study of udenafil in adolescents with single-ventricle heart disease after Fo…

• CLINICAL_TRIALS research · 2025-02-17
  Clinical Trial Update: Registry to Assess the Safety and Feasibility of the Subpulmonary Support with the Novel Venous Cannula in Patients with Failing/Absence of the Right Heart

  A registry entry for a clinical study evaluating the safety and feasibility of a novel venous cannula for subpulmonary support in patients w…

• CLINICAL_TRIALS research · 2025-01-31
  Clinical Trial Update: Virtual Remote Physiological Monitoring Program of Children With Heart Disease [NA]

  This clinical trial update describes the completion of a virtual remote physiological monitoring program for children with heart disease at …

• CLINICAL_TRIALS trial_result · 2022-05-09
  Clinical Trial Update: Colchicine in Postoperative Fontan Patients [Phase 2, Phase 3]

  A Phase 2/Phase 3 clinical trial evaluating colchicine in postoperative Fontan patients has been terminated; results posted in 2022.

• CLINICAL_TRIALS trial_result · 2021-01-22
  Clinical Trial Update: Effect of Carvedilol on Exercise Performance in Fontan Patients [Phase 4]

  Phase 4 trial evaluating the effect of carvedilol on exercise performance in Fontan patients has completed with results posted.

• CLINICAL_TRIALS trial_result · 2018-12-07
  Clinical Trial Update: Study of Effects of Sildenafil on Patients With Fontan Heart Circulation [Phase 4]

  Phase 4 clinical trial updating the effects of sildenafil in patients with Fontan circulation (single ventricle heart disease) after Fontan …

• CLINICAL_TRIALS withdrawal · 2018-05-04
  Clinical Trial Update: Effects of Pulmonary Vasodilation Upon VA Coupling in Fontan Patients [Phase 3]

  Phase 3 trial evaluating pulmonary vasodilation effects on ventricle–arterial coupling in Fontan patients was withdrawn.

• CLINICAL_TRIALS research · 2007-12-28
  Clinical Trial Update: Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation [Phase 2]

  Phase 2 clinical trial in children with a single-ventricle heart undergoing Fontan surgery to study pathophysiological mechanisms of hepatop…