Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Blood Sampling for Research Related to Sickle Cell Disease
NIDDK-sponsored clinical trial on blood sampling for research related to sickle cell disease is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-05Clinical Trial Update: Safety and Efficacy of Gene Therapy of the Sickle Cell Disease by Transplantation of an Autologous CD34+ Enriched Cell Fraction That Contains CD34+ Cells Transduced ex Vivo With the GLOBE1 Lentiviral Vector Expressing the βAS3 Globin Gene in Patients With Sickle Cell Disease (DREPAGLOBE) [Phase 1, Phase 2]
Phase 1/2 trial update on safety and efficacy of autologous CD34+ cells transduced with the GLOBE1 lentiviral vector expressing βAS3 globin …
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: A Blood Stem Cell Transplant for Sickle Cell Disease [Phase 1]
Phase 1 clinical trial update on a blood stem cell transplant for sickle cell disease; the study is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-05Clinical Trial Update: PASS of Xromi Comparing Safety and Effectiveness in Children Under 2 Years With Sickle Cell Disease [PRECISE PASS]
This update describes a post-authorization safety study (PASS) of Xromi evaluating safety and effectiveness in children under 2 with sickle …
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Stroke Prevention in Nigeria 2 Trial [Phase 4]
A Phase 4 clinical trial in Nigeria led by Vanderbilt University Medical Center is evaluating stroke prevention in people with sickle cell d…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA. [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating an autologous CD34+ stem cell gene therapy with a corrected globin gene and silencing RNA for sickl…
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CLINICAL_TRIALS trial_result · 2026-03-04Clinical Trial Update: Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) [Phase 3]
Phase 3 trial updating the status of the SCD-CARRE study evaluating red cell exchange in sickle cell disease; the trial is currently ACTIVE_…
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CLINICAL_TRIALS trial_result · 2026-03-03Clinical Trial Update: Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain [Phase 2]
Phase 2 clinical trial evaluating guided relaxation and acupuncture for chronic pain in sickle cell disease has completed. No results are pr…
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CLINICAL_TRIALS other · 2026-03-02Clinical Trial Update: SickleFit Randomized Control Trial [NA]
Clinical trial update for SickleFit, a randomized controlled trial sponsored by Duke University; current status is not yet recruiting.
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease [NA]
Clinical trial update indicating that recruitment is ongoing for a stress management and mindfulness intervention in patients with Sickle Ce…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Cognitive Remediation Intervention to Prepare for Transition of Care [Phase 2]
A Phase 2 clinical trial evaluating a cognitive remediation intervention to prepare adolescents with sickle cell disease and cognitive impai…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease [Phase 4]
This Phase 4 trial investigates the clinical and biomarker effects of Depot Medroxyprogesterone Acetate in females with sickle cell disease …
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CLINICAL_TRIALS other · 2026-02-27Clinical Trial Update: Safety and Efficacy of KL003 Cell Injection in Severe Sickle Cell Disease [NA]
This update covers the clinical trial of KL003 Cell Injection for severe sickle cell disease, noting that the study is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Siplizumab for Sickle Cell Disease Transplant [Phase 1, Phase 2]
ClinicalTrials.gov shows termination of a Phase 1/2 trial evaluating siplizumab for sickle cell disease, with results posted on 2026-02-27.
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling [EARLY_Phase 1]
This early-phase clinical trial aims to determine red blood cell survival in sickle cell disease and other hemoglobinopathies using biotin l…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Writing Relaxing Beats in Adolescents Who Have Sickle Cell Disease [NA]
Mayo Clinic is recruiting for a clinical study evaluating a music-based intervention called 'Writing Relaxing Beats' in adolescents with sic…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD) [Phase 2]
This document reports an ongoing Phase 2 safety study of Anumigilimab (CSL324) in adults with Sickle Cell Disease, which is currently recrui…
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EMA approval · 2026-02-19EMA Authorised: Casgevy (Exagamglogene autotemcel) — Vertex Pharmaceuticals (Ireland) Limited
EMA authorised Casgevy (exagamglogene autotemcel) by Vertex for beta-thalassemia and sickle cell disease, with conditional approval and orph…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Expanded Access to CD34+ Selection Utilizing Miltenyi CliniMACS Prodigy® for Patients Receiving Peripheral Blood Stem Cell Transplantations and Stem Cell Boosts
This clinical trial update describes expanded access to CD34+ selection using the Miltenyi CliniMACS Prodigy for patients receiving peripher…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease [Phase 4]
A Phase 4 clinical trial is evaluating prophylactic blood transfusions in pregnant women with sickle cell disease and is currently recruitin…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: Epidemiology of Silent and Overt Strokes in Sickle Cell Disease
This clinical trial update describes a study examining the epidemiology of silent and overt strokes in individuals with sickle cell disease,…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease [NA]
An ongoing clinical trial evaluating a mindfulness-based intervention to address pain and sleep problems in adolescents and young adults wit…
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CLINICAL_TRIALS trial_result · 2026-02-13Clinical Trial Update: Non Invasive Positive Pressure Ventilation for Prevention of Acute Chest Syndrome in Sickle Cell Disease [NA]
The clinical trial evaluating noninvasive positive pressure ventilation to prevent acute chest syndrome in sickle cell disease has been term…
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CLINICAL_TRIALS trial_result · 2026-02-12Clinical Trial Update: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pociredir [Phase 1]
This Phase 1 study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of Pociredir in people with sickle cell diseas…
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EMA approval · 2026-02-11EMA Authorised: Siklos (hydroxycarbamide) — Theravia
EMA authorised Siklos (hydroxycarbamide) by Theravia for use in sickle cell disease.