Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2021-06-10Clinical Trial Update: Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertension [Phase 2]
Phase 2 clinical trial evaluating glutamine therapy for hemolysis-associated pulmonary hypertension in patients with sickle cell disease. St…
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CLINICAL_TRIALS trial_result · 2021-04-20Clinical Trial Update: Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis [Phase 2]
Phase 2 clinical trial evaluating adjuvant low-dose ketamine for pediatric sickle cell vaso-occlusive crisis has completed with results post…
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CLINICAL_TRIALS trial_result · 2021-04-09Clinical Trial Update: Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease [Phase 3]
Phase 3 trial assessing ticagrelor vs placebo for reducing vaso-occlusive crises in pediatric sickle cell disease; study terminated with pos…
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CLINICAL_TRIALS trial_result · 2021-04-02Clinical Trial Update: Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises? [Phase 4]
Phase 4 trial assessing whether IV acetaminophen reduces opioid requirements in pediatric patients during acute sickle cell crises; study co…
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CLINICAL_TRIALS trial_result · 2021-03-17Clinical Trial Update: Improving Self-Management in Adolescents With Sickle Cell Disease [NA]
A completed clinical trial focusing on improving self-management in adolescents with sickle cell disease; results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-03-01Clinical Trial Update: Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD) [NA]
Clinical trial update on the role of virtual reality in patients with sickle cell disease; study has terminated with results posted.
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CLINICAL_TRIALS trial_result · 2021-02-10Clinical Trial Update: Safety of Rivipansel (GMI-1070) in the Treatment of One or More Vaso-Occlusive Crises in Hospitalized Subjects With Sickle Cell Disease [Phase 3]
Phase 3 trial of rivipansel (GMI-1070) in hospitalized sickle cell vaso-occlusive crises was terminated.
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CLINICAL_TRIALS trial_result · 2021-02-02Clinical Trial Update: L-Glutamine Therapy for Sickle Cell Anemia [Phase 2]
Phase 2 clinical trial of L-Glutamine therapy for sickle cell anemia has been terminated; results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-01-29Clinical Trial Update: L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 Thalassemia [Phase 2]
Phase 2 clinical trial of L-Glutamine therapy for sickle cell anemia and sickle beta-zero thalassemia completed with results posted.
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CLINICAL_TRIALS trial_result · 2021-01-28Clinical Trial Update: A Phase 2 Study of the Effects of 6R-BH4 in Subjects With Sickle Cell Disease [Phase 2]
Phase 2 trial update on 6R-BH4 for sickle cell disease; study completed with results posted.
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CLINICAL_TRIALS trial_result · 2021-01-27Clinical Trial Update: Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia [Phase 2, Phase 3]
Phase 2/3 clinical trial evaluating different treatment modalities for managing painful crisis in pediatric sickle cell disease has complete…
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CLINICAL_TRIALS trial_result · 2021-01-07Clinical Trial Update: Study to Evaluate the Effect of Voxelotor Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE) [Phase 3]
Phase 3 clinical trial update for voxelotor in sickle cell disease has completed with posted results.
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CLINICAL_TRIALS trial_result · 2020-12-17Clinical Trial Update: Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Pediatric and Young Adult Patients With Sickle Cell Anemia [Phase 2]
Phase 2 clinical trial evaluating the efficacy, safety and tolerability of canakinumab (ACZ885) in pediatric and young adult patients with s…
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CLINICAL_TRIALS trial_result · 2020-12-08Clinical Trial Update: Macitentan in Pulmonary Hypertension of Sickle Cell Disease [Phase 2]
Phase 2 trial of macitentan for pulmonary hypertension associated with sickle cell disease was terminated; results have been posted.
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CLINICAL_TRIALS trial_result · 2020-11-09Clinical Trial Update: Realizing Effectiveness Across Continents With Hydroxyurea (REACH) [Phase 1, Phase 2]
This clinical trial update covers hydroxyurea in Phase 1/2 for sickle cell disease, with results posted on 2020-11-09.
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CLINICAL_TRIALS trial_result · 2020-11-06Clinical Trial Update: Contraception in Women With Sickle Cell Disease [Phase 4]
A Phase 4 clinical trial investigating contraception in women with sickle cell disease has completed.
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CLINICAL_TRIALS trial_result · 2020-11-05Clinical Trial Update: HSCT For Patients With High Risk Hemoglobinopathies Using Reduced Intensity [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating reduced intensity conditioning and hematopoietic stem cell transplantation for high-risk hemoglobinopa…
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CLINICAL_TRIALS research · 2020-11-02Clinical Trial Update: Novel Cardiac Magnetic Resonance Imaging to Define a Unique Restrictive Cardiomyopathy in Sickle Cell Disease
A completed clinical trial evaluating cardiac MRI to define a specific restrictive cardiomyopathy in patients with sickle cell disease; resu…
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FDA approval · 2020-10-29FDA Approved: ENDARI — Supplemental Application (Emmaus Medical, Inc.)
FDA approved a supplemental application for Endari (L-glutamine) from Emmaus Medical, Inc.
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CLINICAL_TRIALS trial_result · 2020-10-19Clinical Trial Update: Omega-3 Fatty Acids in Sickle Cell Disease [Phase 1, Phase 2]
A clinical trial update on omega-3 fatty acids in sickle cell disease has been terminated with results posted.
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CLINICAL_TRIALS research · 2020-10-19Clinical Trial Update: Carbon Monoxide Measurement to Screen for Sickle Cell Disease [NA]
A completed clinical trial investigating carbon monoxide measurement as a screening tool for sickle cell disease.
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CLINICAL_TRIALS trial_result · 2020-10-14Clinical Trial Update: Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies [Phase 1, Phase 2]
Phase I/II pilot study investigating mixed chimerism as a treatment approach for sickle cell disease has completed.
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CLINICAL_TRIALS research · 2020-10-12Clinical Trial Update: Central Nervous System Vascular Changes in Adult Sickle Cell Disease and the Effect of Treatment With Simvastatin [Phase 1, Phase 2]
Phase 1/2 trial evaluating central nervous system vascular changes in adult sickle cell disease and the effect of simvastatin treatment.
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CLINICAL_TRIALS trial_result · 2020-10-08Clinical Trial Update: Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease [Phase 4]
Phase 4 trial comparing ketorolac to ibuprofen for painful episodes in sickle cell disease was terminated with results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-10-01Clinical Trial Update: Assessing the Safety of Buprenorphine in People With Sickle Cell Disease [Phase 2]
Phase 2 trial assessing the safety of buprenorphine in people with sickle cell disease has completed with results posted.