Sickle Cell Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2024-01-08Clinical Trial Update: Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients [Phase 3]
Phase 3 study comparing two doses of crizanlizumab to placebo in adolescents and adults with sickle cell disease; results were posted in 202…
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CLINICAL_TRIALS trial_result · 2024-01-08Clinical Trial Update: Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients [Phase 3]
Phase 3 trial comparing two doses of crizanlizumab to placebo in adolescents and adults with sickle cell disease.
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CLINICAL_TRIALS trial_result · 2023-12-26Clinical Trial Update: Intranasal Sufentanil for Analgesia of Severe Sickle Cell Vaso-occlusive Pain Crisis in the Pediatric [Phase 3]
Phase 3 clinical trial evaluating intranasal sufentanil for analgesia in pediatric severe sickle cell vaso-occlusive crisis; not yet recruit…
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EMA approval · 2023-12-15First gene editing therapy to treat beta thalassemia and severe sickle cell disease
EMA recommended approval of Casgevy, the first gene-editing therapy using CRISPR/Cas9 for transfusion-dependent beta-thalassemia and severe …
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CLINICAL_TRIALS trial_result · 2023-12-13Clinical Trial Update: iCanCope With Sickle Cell Pain [NA]
Clinical trial update for the iCanCope with Sickle Cell Pain study has completed; results posted in December 2023.
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CLINICAL_TRIALS trial_result · 2023-12-08Clinical Trial Update: Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome [Phase 2]
Phase 2 trial update on defibrotide for sickle cell disease–related acute chest syndrome has completed.
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CLINICAL_TRIALS trial_result · 2023-11-22Clinical Trial Update: Integration of mHEALTH Into the Care of Patients With Sickle Cell Disease to Increase Hydroxyurea Utilization [NA]
Clinical trial update on integrating mHealth into care to increase hydroxyurea utilization in sickle cell disease; study completed with resu…
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CLINICAL_TRIALS trial_result · 2023-11-21Clinical Trial Update: Actigraphy Improvement With Voxelotor (ActIVe) Study [Phase 4]
Phase 4 trial update evaluating actigraphy improvements with voxelotor (ActIVe) in sickle cell disease patients has completed with results p…
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CLINICAL_TRIALS trial_result · 2023-11-21Clinical Trial Update: Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCD [Phase 2]
Phase 2 dose-escalation trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of voxelotor in patients with sickl…
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FDA approval · 2023-11-14FDA Approved: DEFERASIROX — Supplemental Application (Sun Pharmaceutical Industries, Inc.)
FDA approved a supplemental application for deferasirox submitted by Sun Pharmaceutical Industries, Inc., approving changes to the product l…
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CLINICAL_TRIALS trial_result · 2023-11-01Clinical Trial Update: SMILES: Study of Montelukast in Sickle Cell Disease [Phase 2, Phase 3]
A clinical trial update for Montelukast in sickle cell disease progressing through Phase 2 and Phase 3.
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CLINICAL_TRIALS trial_result · 2023-10-18Clinical Trial Update: A Study of IMR-687 in Subjects With Sickle Cell Disease [Phase 2]
Phase 2 study of IMR-687 in sickle cell disease has been terminated and results have been posted.
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CLINICAL_TRIALS trial_result · 2023-10-12Clinical Trial Update: Transplantation for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow [Phase 2]
Phase 2 clinical trial evaluating transplantation from mismatched family donors of bone marrow for patients with sickle cell disease has com…
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EMA withdrawal · 2023-09-29EMA Revoked: Adakveo (Crizanlizumab) — Novartis Europharm Limited
EMA has revoked Adakveo (crizanlizumab) marketed by Novartis Europharm Limited for sickle cell disease/anemia.
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CLINICAL_TRIALS trial_result · 2023-09-26Clinical Trial Update: Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study [Phase 1, Phase 2]
Long-term follow-up update from BP-004 study (Phase 1/Phase 2) by Bellicum Pharmaceuticals; study status TERMINATED with results posted in 2…
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CLINICAL_TRIALS trial_result · 2023-09-21Clinical Trial Update: Hemolysis Related Complications in SCD. A Phase II Study With Voxelotor [Phase 2]
Phase II trial investigating voxelotor for sickle cell disease focusing on hemolysis-related complications; current status unknown.
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CLINICAL_TRIALS trial_result · 2023-09-15Clinical Trial Update: Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating conditioning regimens for allogeneic hematopoietic stem-cell transplantation has completed recruitment…
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CLINICAL_TRIALS trial_result · 2023-08-29Clinical Trial Update: Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis [Phase 2]
Phase 2 trial investigating intravenous lidocaine for emergency department management of sickle cell crisis.
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FDA approval · 2023-08-18FDA Approved: OXBRYTA — Supplemental Application (Global Blood Therapeutics, Inc, A subsidiary of Pfizer Inc.)
FDA approved a supplemental application for OXBRYTA (voxelotor) submitted by Global Blood Therapeutics, Inc., a subsidiary of Pfizer, to upd…
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FDA approval · 2023-08-18FDA Approved: OXBRYTA — Supplemental Application (Global Blood Therapeutics, Inc, A subsidiary of Pfizer Inc.)
FDA approved a supplemental application for OXBRYTA (voxelotor) from Global Blood Therapeutics, a subsidiary of Pfizer Inc.
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CLINICAL_TRIALS trial_result · 2023-08-14Clinical Trial Update: Measurement of Cerebral Blood Flow Using Transcranial Doppler Ultrasound in Children With Sickle Cell Disease [NA]
A completed clinical trial evaluating transcranial Doppler ultrasound to measure cerebral blood flow in children with sickle cell disease; r…
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CLINICAL_TRIALS trial_result · 2023-07-21Clinical Trial Update: A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD) [Phase 2]
Phase 2 trial investigating olinciguat (IW-1701), a soluble guanylate cyclase stimulator, in sickle cell disease has completed with results …
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CLINICAL_TRIALS trial_result · 2023-07-19Clinical Trial Update: A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseases [Phase 2]
Phase 2 multicenter trial evaluating riociguat in patients with sickle cell disease has been completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-07-03Clinical Trial Update: Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Disease [Phase 3]
A Phase 3 trial comparing individualized versus weight-based treatment protocols for vaso-occlusive episodes in sickle cell disease was term…
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CLINICAL_TRIALS trial_result · 2023-06-27Clinical Trial Update: Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease [Phase 2]
A Phase 2 clinical trial evaluating fixed-dose flavonoid isoquercetin on thrombo-inflammatory biomarkers in adults with stable sickle cell d…