Septic Shock
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CLINICAL_TRIALS trial_result · 2013-11-27Clinical Trial Update: Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial update investigating how hyperglycemia influences PAI-1 activity and its relation to outcomes in severe sep…
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CLINICAL_TRIALS trial_result · 2013-10-31Clinical Trial Update: Early Haemodynamic Optimization Using Preload Dependence During Septic Shock = EHOSS-1 [NA]
EHOSS-1 investigated preload-dependent haemodynamic optimization in septic shock and has completed.
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CLINICAL_TRIALS research · 2013-10-22Clinical Trial Update: Activated Protein C and Microcirculation
A completed clinical trial examining activated protein C and its effects on microcirculation in patients with severe sepsis and septic shock…
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CLINICAL_TRIALS trial_result · 2013-10-01Clinical Trial Update: Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
A completed clinical trial assessing how acute respiratory distress syndrome and severe sepsis influence soluble RAGE (sRAGE) levels in ICU …
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CLINICAL_TRIALS trial_result · 2013-09-27Clinical Trial Update: Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis
A clinical trial studying skeletal muscle and platelet mitochondrial dysfunction during sepsis has completed.
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CLINICAL_TRIALS trial_result · 2013-09-23Clinical Trial Update: A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock [Phase 2]
This document reports the results of a Phase 2 trial comparing two IV dosing regimens of AZD9773 (CytoFab) versus placebo in adults with sev…
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CLINICAL_TRIALS research · 2013-09-20Clinical Trial Update: Catheter Early Withdrawal or Maintenance in Sepsis or Septic Shock [NA]
This clinical trial update concerns NCT01947751, a study comparing early withdrawal versus maintenance of a catheter in patients with sepsis…
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CLINICAL_TRIALS trial_result · 2013-08-22Clinical Trial Update: A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock [Phase 2]
Phase 2 study evaluating two doses of AZD9773 (CytoFab) in Japanese patients with severe sepsis or septic shock to assess safety and tolerab…
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CLINICAL_TRIALS research · 2013-08-12Clinical Trial Update: Focused Ultrasound in Septic Shock Patients [NA]
This clinical trial update describes a study evaluating focused ultrasound in septic shock patients conducted by Peking Union Medical Colleg…
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CLINICAL_TRIALS research · 2013-07-25Clinical Trial Update: A Retrospective Review of a Comprehensive Cohort of Septic Shock: Assessment of Critical Determinants of Outcome
This document reports a retrospective cohort analysis of septic shock patients and identifies key determinants associated with patient outco…
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CLINICAL_TRIALS research · 2013-07-25Clinical Trial Update: Cytokine Response in Septic Shock
An update on a University of Manitoba–led clinical trial investigating cytokine responses in septic shock.
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CLINICAL_TRIALS trial_result · 2013-07-19Clinical Trial Update: Epidemiology of Septic Shock in Medical or Polyvalent ICU in the North-East Region of France
A clinical trial examining the epidemiology of septic shock in ICUs in northeast France has been terminated.
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CLINICAL_TRIALS research · 2013-06-14Clinical Trial Update: Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy [NA]
Clinical trial evaluating whether targeting venoarterial PCO2 difference and arteriovenous O2 content difference ratio can guide early septi…
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CLINICAL_TRIALS trial_result · 2013-05-21Clinical Trial Update: Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock [Phase 3]
Phase 3 clinical trial evaluating the efficacy of melatonin in patients with severe sepsis or septic shock; current status is unknown.
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CLINICAL_TRIALS research · 2013-05-10Clinical Trial Update: Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia [Phase 1, Phase 2]
A Russian Phase 1/2 clinical trial is exploring mesenchymal cell therapy for septic shock and several forms of neutropenia, including drug-i…
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CLINICAL_TRIALS trial_result · 2013-04-30Clinical Trial Update: GCIV as an Adjuvant Therapy for Community-Acquired Severe Sepsis or Septic Shock [Phase 3]
A Phase 3 trial of GCIV as adjuvant therapy for community-acquired severe sepsis or septic shock has been terminated.
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CLINICAL_TRIALS research · 2013-04-26Clinical Trial Update: Prognostic Evaluation Of Severe Sepsis And Septic Shock. Procalcitonin Versus Delta Sofa
This clinical trial update evaluates prognostic markers in severe sepsis and septic shock, comparing procalcitonin levels to Delta SOFA scor…
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CLINICAL_TRIALS trial_result · 2013-04-09Clinical Trial Update: Assessment of Fluid Responsiveness by Elevation of PEEP in Patients With Septic Shock [NA]
A completed clinical trial evaluating whether elevating PEEP can be used to assess fluid responsiveness in patients with septic shock.
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CLINICAL_TRIALS trial_result · 2013-01-30Clinical Trial Update: Polydatin Injectable (HW6) for Shock Treatment [Phase 2]
Phase 2 clinical trial update for Polydatin Injectable (HW6) as a treatment for various forms of shock, including hemorrhagic, traumatic, an…
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CLINICAL_TRIALS trial_result · 2013-01-29Clinical Trial Update: Dose-response Study of Arginine Supplementation in Severe Sepsis [EARLY_Phase 1]
Completed early-phase 1 dose-response study evaluating arginine supplementation in patients with severe sepsis and septic shock. The trial i…
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CLINICAL_TRIALS trial_result · 2013-01-24Clinical Trial Update: Heart Rate Control With Esmolol in Septic Shock [Phase 2]
Phase 2 trial evaluating heart rate control with esmolol in septic shock has completed.
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CLINICAL_TRIALS research · 2012-12-11Clinical Trial Update: Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome
This clinical trial update describes a study investigating cardiac stress in septic shock, including biomarkers and echocardiography, and ho…
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CLINICAL_TRIALS trial_result · 2012-12-07Clinical Trial Update: Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock [Phase 3]
Phase 3 trial comparing dopamine to norepinephrine for vasopressor-dependent septic shock; study completed with results posted in 2012.
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CLINICAL_TRIALS trial_result · 2012-11-29Clinical Trial Update: Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock
A clinical trial update evaluating fluid resuscitation approaches in children with cancer who have severe sepsis or septic shock.
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CLINICAL_TRIALS research · 2012-11-14Clinical Trial Update: Investigation of the Role of Brain Natriuretic Peptide and Lactate in Early Goal-directed Therapy for Patients With Severe Sepsis and Septic Shock
This clinical trial update investigates whether brain natriuretic peptide and lactate measurements can inform early goal-directed therapy fo…