Septic Shock
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CLINICAL_TRIALS research · 2024-07-10Clinical Trial Update: Evaluation of the Association Between Right Atrial Reservoir Strain Variation and Fluid Responsiveness in Patients With Septic Shock [NA]
Clinical trial assessing whether right atrial reservoir strain variation correlates with fluid responsiveness in patients with septic shock;…
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CLINICAL_TRIALS research · 2024-07-10Clinical Trial Update: Echocardiographic Evaluation of RV Injury in the ICU
This clinical trial update describes an echocardiographic study of right ventricular injury in ICU patients, examining associations with rig…
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CLINICAL_TRIALS trial_result · 2024-07-05Clinical Trial Update: Low Dose Versus High Dose Methylene Blue in Septic Patients [Phase 2, Phase 3]
This document reports the completion of a Phase 2/3 trial comparing low-dose versus high-dose methylene blue in patients with septic shock.
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CLINICAL_TRIALS trial_result · 2024-07-03Clinical Trial Update: ILOPROST in Septic Shock With Persistent Microperfusion Defects (I-MICRO) [Phase 3]
Phase 3 trial of iloprost for septic shock with persistent microperfusion defects has completed.
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CLINICAL_TRIALS research · 2024-06-27Clinical Trial Update: Proteinuria During Sepsis and Septic Shock: Characterization and Association With ARDS
Clinical trial investigating proteinuria during sepsis and septic shock and its association with acute respiratory distress syndrome (ARDS).
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CLINICAL_TRIALS trial_result · 2024-06-25Clinical Trial Update: TRANSfusion in Patients With Onco-hematological Malignancies ResusciTated From Septic Shock [Phase 3]
A Phase 3 clinical trial evaluating transfusion in patients with hematologic malignancies resuscitated from septic shock has completed.
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CLINICAL_TRIALS research · 2024-06-24Clinical Trial Update: Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock [Phase 4]
A Phase 4 study is evaluating the renal outcomes of early vasopressin use in treating septic shock, with enrollment currently ongoing.
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis
A completed clinical trial investigating the role and mechanisms of lipid and lipoprotein dysregulation in sepsis and septic shock.
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CLINICAL_TRIALS trial_result · 2024-06-20Clinical Trial Update: The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock [Phase 2, Phase 3]
This trial update notes the completion of Phase 2/Phase 3 studies evaluating early norepinephrine in pediatric septic shock, with measuremen…
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CLINICAL_TRIALS research · 2024-06-20Clinical Trial Update: UK ANDROMEDA-Shock-2 RCT [NA]
The UK ANDROMEDA-Shock-2 randomized controlled trial investigating septic shock is currently not recruiting.
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CLINICAL_TRIALS research · 2024-06-12Clinical Trial Update: Septic Shock-induced Immunosuppression
This clinical trial update notes that a study on septic shock–induced immunosuppression is currently recruiting.
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FDA approval · 2024-06-11FDA Approved: NOREPINEPHRINE BITARTRATE — Supplemental Application (Baxter Healthcare Corporation)
FDA approved a supplemental application for norepinephrine bitartrate from Baxter Healthcare Corporation.
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CLINICAL_TRIALS trial_result · 2024-06-07Clinical Trial Update: Effects of Fluid Therapy on Peripheral TIssse Perfusion During Sepsis/Septic Shock
This entry notes the completion of a clinical trial evaluating the effect of fluid therapy on peripheral tissue perfusion in septic shock or…
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CLINICAL_TRIALS research · 2024-06-06Clinical Trial Update: Effect of Early Administration of Albumin 20% Versus Crystalloid [NA]
This document reports an ongoing clinical trial comparing early administration of albumin 20% to crystalloid solutions in patients with sept…
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CLINICAL_TRIALS trial_result · 2024-06-05Clinical Trial Update: Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock
A clinical trial evaluating the combination of hemoperfusion and therapeutic plasma exchange for septic shock has completed.
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CLINICAL_TRIALS research · 2024-05-23Clinical Trial Update: Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock [Phase 4]
An ongoing Phase 4 clinical trial evaluating angiotensin-II as a second vasopressor for septic shock, currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-05-21Clinical Trial Update: Effect of Norepinephrine Administration on Ventricular Systolic Function in Septic Shock
A completed clinical trial evaluating the effect of norepinephrine administration on ventricular systolic function in patients with septic s…
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CLINICAL_TRIALS trial_result · 2024-05-16Clinical Trial Update: Can Shock Indices Be Prognostic Indicators in Sepsis/Septic Shock?
A completed clinical study evaluated whether shock indices can serve as prognostic indicators in patients with sepsis and septic shock.
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CLINICAL_TRIALS trial_result · 2024-05-07Clinical Trial Update: Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluating 72-hour infusion of iloprost versus placebo in septic shock with organ failure has completed.
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CLINICAL_TRIALS trial_result · 2024-04-26Clinical Trial Update: Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock.
This completed clinical trial investigated the pro-inflammatory role of blood platelets in critically ill patients with septic shock.
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CLINICAL_TRIALS trial_result · 2024-04-12Clinical Trial Update: Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study [Phase 1]
Phase 1 pilot study evaluating intravenous AII for severe hypotension in septic shock; completed with results posted.
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CLINICAL_TRIALS withdrawal · 2024-03-15Clinical Trial Update: Angiotensin II vs. Vasopressin in Septic Shock [Phase 4]
Phase 4 clinical trial comparing Angiotensin II versus Vasopressin in septic shock has been withdrawn.
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CLINICAL_TRIALS trial_result · 2024-03-13Clinical Trial Update: Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis [Phase 1, Phase 2]
A Clinical Trial Update reports that apigenin may improve organ function in elderly patients with sepsis and septic shock, across Phase 1 an…
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CLINICAL_TRIALS trial_result · 2024-03-12Clinical Trial Update: Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock [Phase 2, Phase 3]
Clinical trial evaluating intravenous methylene blue for refractory neonatal septic shock, currently in Phase 2/Phase 3 and not yet recruiti…
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CLINICAL_TRIALS trial_result · 2024-03-12Clinical Trial Update: Dexmedetomidine and Vasopressin in Septic Shock [Phase 2]
Phase 2 trial update on dexmedetomidine and vasopressin in septic shock; status currently unknown.