Richter Transformation
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: A Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies [Phase 1]
Phase 1 clinical trial update of BGB-21447, a Bcl-2 inhibitor developed by BeOne Medicines, evaluating safety and preliminary activity in mu…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006) [Phase 2]
This clinical trial update reports on a Phase 2 study of Zilovertamab Vedotin (MK-2140) as monotherapy and in combination for aggressive and…
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CLINICAL_TRIALS trial_result · 2026-03-10Clinical Trial Update: Study of Brexucabtagene Autoleucel in Adults With Rare B-cell Malignancies [Phase 2]
Phase 2 trial of Brexucabtagene Autoleucel in adults with rare B-cell malignancies has been terminated with results posted.
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: CD45BE-HSPC + CART-45 Cells [Phase 1]
Phase 1 study evaluating CD45BE-HSPC with CART-45 cells is not yet recruiting and targets B-cell non-Hodgkin lymphoma and Richter transforma…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT) [Phase 2]
A Phase 2 clinical trial is evaluating a time-limited triplet therapy of pirtobrutinib, venetoclax, and obinutuzumab for treatment-naïve chr…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: ONO-4538 Study in Patients With Richter's Transformation [Phase 2]
Phase 2 clinical trial of ONO-4538 (nivolumab) in patients with Richter's transformation is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation [Phase 2]
Phase 2 clinical trial evaluating glofitamab as monotherapy and in combination with polatuzumab vedotin, pirtobrutinib, or atezolizumab for …
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CLINICAL_TRIALS other · 2025-12-08Clinical Trial Update: Registry of the German CLL Study Group
Ongoing registry study by the German CLL Study Group recruiting participants for trials involving chronic lymphocytic leukemia, small lympho…
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CLINICAL_TRIALS other · 2025-09-08Clinical Trial Update: A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001) [Phase 1, Phase 2]
This clinical trial update indicates that Nemtabrutinib (MK-1026) is being studied for relapsed or refractory hematologic malignancies in a …
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CLINICAL_TRIALS other · 2025-04-24Clinical Trial Update: DALY II USA/ MB-CART2019.1 for DLBCL [Phase 2]
Miltenyi Biomedicine's MB-CART2019.1 (DALY II) is in Phase 2 for refractory/relapsed B-cell lymphomas, including Diffuse Large B-Cell Lympho…
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CLINICAL_TRIALS trial_result · 2025-01-08Clinical Trial Update: Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas [Phase 2]
A Phase 2 study evaluating the triple combination therapy DTRM-555 in relapsed/refractory chronic lymphocytic leukemia and relapsed/refracto…
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CLINICAL_TRIALS research · 2024-12-30Clinical Trial Update: Efficacy and Safety of Zanubrutinib Plus Tislelizumab Treatment with or Without Sonrotoclax for Patients with Richter Transformation [Phase 2]
Phase 2 clinical trial evaluating zanubrutinib plus tislelizumab with or without sonrotoclax for Richter transformation; currently recruitin…
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CLINICAL_TRIALS approval · 2024-12-18Clinical Trial Update: Expanded Access Program for Pirtobrutinib for Participants With B-Cell Cancer
The document notes that pirtobrutinib is approved for marketing in relation to an expanded access program for multiple B-cell cancers, cover…
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CLINICAL_TRIALS trial_result · 2024-07-31Clinical Trial Update: Study of TG-1801 Alone or in Combination With Ublituximab in Subjects With B-Cell Lymphoma or Chronic Lymphocytic Leukemia [Phase 1]
Phase 1 study assessing TG-1801 alone or with ublituximab in patients with CLL, SLL, and other B-cell lymphomas was terminated.
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CLINICAL_TRIALS trial_result · 2024-03-20Clinical Trial Update: Nivolumab and Ibrutinib in Treating Patients With Relapsed, Refractory, or High-Risk Untreated Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Richter Transformation [Phase 2]
Phase 2 trial evaluating nivolumab and ibrutinib in relapsed/refractory or high-risk untreated chronic lymphocytic leukemia, small lymphocyt…
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CLINICAL_TRIALS trial_result · 2023-02-17Clinical Trial Update: Ibrutinib, Nivolumab and Blinatumomab in Richter Transformation [Phase 2]
Phase 2 trial evaluating a combination of ibrutinib, nivolumab, and blinatumomab in Richter transformation has been terminated; results post…
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CLINICAL_TRIALS trial_result · 2022-05-06Clinical Trial Update: ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies [Phase 1, Phase 2]
Phase 1/2 trial of acalabrutinib (ACP-196) in combination with pembrolizumab in hematologic malignancies has completed with results posted i…
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CLINICAL_TRIALS trial_result · 2021-08-05Clinical Trial Update: R-EPOCH in Combination With Ibrutinib for Patients With Classical RT of CLL [Phase 2]
Phase 2 trial evaluating R-EPOCH with Ibrutinib for Richter Transformation in chronic lymphocytic leukemia, status unknown.
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CLINICAL_TRIALS trial_result · 2021-01-06Clinical Trial Update: A Study of Acalabrutinib and Vistusertib in Subjects With Relapsed/Refractory B-cell Malignancies [Phase 1, Phase 2]
Phase 1/2 trial of acalabrutinib plus vistusertib in relapsed/refractory B-cell malignancies (DLBCL and Richter syndrome) was terminated.
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CLINICAL_TRIALS trial_result · 2020-03-10Clinical Trial Update: PNT2258 for Treatment of Patients With Richter's Transformation (Brighton) [Phase 2]
Phase 2 trial update for PNT2258 in Richter's transformation has been terminated with posted results.
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CLINICAL_TRIALS trial_result · 2020-02-11Clinical Trial Update: Selinexor in Initial or Refractory and/or Relapsed Richter's Transformation [Phase 2]
Phase 2 clinical trial update for selinexor in Richter's transformation (initial or refractory/relapsed); study terminated with results post…
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CLINICAL_TRIALS trial_result · 2016-10-03Clinical Trial Update: Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia (CLL) That Did Not Respond to Fludarabine, CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT) [Phase 2]
Phase 2 trial evaluating rituximab-based combination chemotherapy in patients with chronic lymphocytic leukemia that did not respond to flud…
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CLINICAL_TRIALS trial_result · 2011-08-29Clinical Trial Update: Oxaliplatin, Fludarabine, Cytarabine and Rituximab in Richter's Syndrome, Refractory CLL and PLL [Phase 1, Phase 2]
A Phase 1/2 study evaluating oxaliplatin, fludarabine, cytarabine, and rituximab in Richter's syndrome and refractory chronic lymphocytic le…