Richter Syndrome
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-Degrader [Phase 1, Phase 2]
Ongoing Phase 1/2 clinical trial update for BGB-16673, a BTK-targeted protein degrader, in Chinese participants with various B-cell malignan…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell Non-Hodgkin and Hodgkin Lymphoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial update describes autologous stem cell transplant followed by polatuzumab vedotin for patients with various B-cell…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the safety and efficacy of epcoritamab in subjects with relapsed/refractory chronic lymphocytic leukem…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma [Phase 1]
A Phase 1 trial is evaluating the addition of the immunotherapy atezolizumab to a Rituximab-Gemcitabine-Oxaliplatin regimen for relapsed/ref…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Acalabrutinib, Venetoclax and Durvalumab for the Treatment of Richter Transformation From Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 2]
A Phase 2 clinical trial evaluating a three-drug combination (acalabrutinib, venetoclax, and durvalumab) for Richter transformation arising …
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype [Phase 2]
Phase 2 study evaluating nemtabrutinib combined with pembrolizumab for Richter transformation and Diffuse Large B-Cell Lymphoma in patients …
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CLINICAL_TRIALS trial_result · 2026-03-23Clinical Trial Update: Duvelisib and Venetoclax in Relapsed or Refractory CLL or SLL or RS [Phase 1, Phase 2]
Clinical trial update on the Phase 1/2 study of the duvelisib and venetoclax combination in relapsed or refractory Chronic Lymphocytic Leuke…
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CLINICAL_TRIALS trial_result · 2026-03-20Clinical Trial Update: ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphoma [Phase 1, Phase 2]
A Phase 1/2 study evaluating ALX148 in combination with Rituximab and Lenalidomide for various B-cell non-Hodgkin lymphomas, with the trial …
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Zanubrutinib and Lisocabtagene Maraleucel for the Treatment of Richter's Syndrome [Phase 2]
A Phase 2 clinical trial update evaluating the combination of zanubrutinib and lisocabtagene maraleucel for Richter's syndrome, with patient…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: A Study of APG-3288 in Relapsed/Refractory Blood Cancers [Phase 1]
Phase 1 study of APG-3288 in relapsed/refractory hematologic cancers; the trial is not yet recruiting.
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Epcoritamab in Chronic Lymphocytic Leukemia and Richter Syndrome [Phase 1]
Phase 1 clinical trial update evaluating epcoritamab in chronic lymphocytic leukemia and Richter syndrome. The study is currently active but…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome [Phase 2]
Phase 2 clinical trial evaluating a triple-drug regimen (atezolizumab, obinutuzumab, and venetoclax) for chronic lymphocytic leukemia, small…
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CLINICAL_TRIALS trial_result · 2026-01-26Clinical Trial Update: A Study of PRT2527 as Monotherapy and in Combination With Zanubrutinib or Venetoclax in Participants With R/R Hematologic Malignancies [Phase 1]
A Phase 1 clinical trial evaluates PRT2527 as a standalone therapy and in combination with zanubrutinib or venetoclax for relapsed/refractor…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma [Phase 1]
A Phase 1 trial is evaluating the combination of copanlisib and nivolumab in patients with Richter's transformation or transformed indolent …
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Lisocabtagene Maraleucel, Nivolumab and Ibrutinib for the Treatment of Richter's Transformation [Phase 2]
A Phase 2 clinical trial is evaluating a triple therapy consisting of lisocabtagene maraleucel, nivolumab, and ibrutinib for Richter transfo…
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CLINICAL_TRIALS trial_result · 2025-12-10Clinical Trial Update: Evaluation of Treatment by Glofitamab in Combination With Rituximab or Obinutuzumab Plus CHOP in Patients With RIchter Syndrome [Phase 2]
Phase 2 clinical trial evaluating glofitamab in combination with rituximab or obinutuzumab plus CHOP for Richter syndrome; recruitment is on…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma [Phase 1]
This clinical trial update describes a Phase 1 study of pevonedistat in combination with ibrutinib for relapsed or refractory chronic lympho…
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CLINICAL_TRIALS research · 2025-10-23Clinical Trial Update: Adding Pirtobrutinib to the Usual Treatment for People With Newly Diagnosed Richter Transformation, The PIRAMID Trial [Phase 3]
Phase 3 PIRAMID trial evaluating adding pirtobrutinib to standard therapy for newly diagnosed Richter transformation (transformed CLL/SLL to…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Polatuzumab Vedotin in Combination With Chemotherapy in Subjects With Richter's Transformation [Phase 2]
Phase 2 clinical trial evaluating polatuzumab vedotin in combination with chemotherapy for Richter syndrome and chronic lymphocytic leukemia…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation [Phase 1]
Phase 1 trial evaluating Zanubrutinib in combination with Odronextamab for Richter transformation in transformed chronic lymphocytic leukemi…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: A Phase II Study of Venetoclax in Combination With Dose-adjusted EPOCH-R or R-CHOP for Patients With Richter's Syndrome [Phase 2]
Phase II study evaluating venetoclax with dose-adjusted EPOCH-R or R-CHOP for Richter syndrome; current status is active but not recruiting.
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: CHOP Plus Mosunetuzumab as First Line in Patients With Richter´s Syndrome: a Phase II Study of the Spanish Group of CLL [Phase 2]
A Phase II trial in Spain is evaluating CHOP chemotherapy plus mosunetuzumab as first-line treatment for Richter syndrome. The study is curr…
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CLINICAL_TRIALS withdrawal · 2025-02-28Clinical Trial Update: Ipilimumab, Ibrutinib, and Nivolumab for the Treatment of Chronic Lymphocytic Leukemia and Richter Transformation [Phase 1]
Phase 1 trial of ipilimumab, ibrutinib, and nivolumab for chronic lymphocytic leukemia and Richter transformation has been withdrawn.
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CLINICAL_TRIALS trial_result · 2024-12-10Clinical Trial Update: A Study to Evaluate Efficacy & Safety of Obinutuzumab, Ibrutinib, and Venetoclax in Richter's Syndrome; [Phase 2]
A Phase 2 study evaluating the efficacy and safety of a triple therapy with obinutuzumab, ibrutinib, and venetoclax in Richter's Syndrome ha…
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CLINICAL_TRIALS research · 2024-05-28Clinical Trial Update: ObinutuzuMab AtezOlizumab and VenetocLax in RichTer transfOrmation [Phase 2]
Phase 2 trial evaluating a triple therapy of obinutuzumab, atezolizumab, and venetoclax for Richter transformation in chronic lymphocytic le…