Rhabdomyosarcoma

CLINICAL_TRIALS research · 2025-12-17

Clinical Trial Update: Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors [Phase 1]

Phase I clinical trial update evaluating dose, pharmacokinetics, and safety of Lutetium-177-edotreotide therapy in pediatric participants wi…

CLINICAL_TRIALS research · 2025-11-26

Clinical Trial Update: Evolutionary Therapy for Rhabdomyosarcoma [Phase 2]

This update reports an ongoing Phase 2 clinical trial of an evolutionary therapy for rhabdomyosarcoma, sponsored by H. Lee Moffitt Cancer Ce…

CLINICAL_TRIALS research · 2025-11-20

Clinical Trial Update: B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults [Phase 1]

Phase 1 clinical trial update describing B7H3-targeted CAR T-cell therapy for recurrent/refractory pediatric solid tumors, including several…

CLINICAL_TRIALS research · 2025-11-20

Clinical Trial Update: EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults [Phase 1]

A Phase 1 trial update for EGFR806 CAR T cell immunotherapy in pediatric and young adult patients with recurrent/refractory solid tumors; th…

CLINICAL_TRIALS research · 2025-11-03

Clinical Trial Update: Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells [Phase 1]

Phase 1 clinical trial evaluating GPC3-targeted CAR T cells armored with IL-15 and IL-21 for GPC3-positive solid tumors; currently recruitin…

CLINICAL_TRIALS research · 2025-10-16

Clinical Trial Update: Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors [Phase 1]

Phase 1 pediatric trial evaluating alpha/beta CD19+ depleted haploidentical transplantation in combination with Zoledronic acid (Zometa) for…

CLINICAL_TRIALS research · 2025-09-23

Clinical Trial Update: Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors [Phase 1]

Phase 1 study evaluating flavored oral irinotecan VAL-413 (Orotecan) with temozolomide for recurrent pediatric solid tumors is currently rec…

CLINICAL_TRIALS research · 2025-08-24

Clinical Trial Update: Ivonescimab in the Treatment of Multiple Advanced Tumors [Phase 2]

An update indicating Ivonescimab is being studied in a Phase 2 trial for multiple advanced tumors and is currently recruiting. The trial cov…

CLINICAL_TRIALS research · 2025-08-22

Clinical Trial Update: Anlotinib Hydrochloride Capsules in Maintenance Treatment for Intermediate-High Risk Rhabdomyosarcoma in Children [Phase 2]

This entry reports a Phase 2 clinical trial evaluating anlotinib hydrochloride capsules as maintenance therapy for intermediate-high risk pe…

CLINICAL_TRIALS research · 2025-08-19

Clinical Trial Update: Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease [Phase 2]

A Phase 2 clinical trial in children with intermediate and high-risk rhabdomyosarcoma using liposomal irinotecan-based therapy guided by mol…

CLINICAL_TRIALS research · 2025-07-25

Clinical Trial Update: C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma and Other GD2 Positive Cancers (GAIL-N) [Phase 1]

ClinicalTrials.gov entry updates the Phase 1 study of C7R-GD2.CART cells for relapsed or refractory GD2-positive cancers, including neurobla…

CLINICAL_TRIALS research · 2025-07-11

Clinical Trial Update: Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling [Phase 1]

Phase 1 clinical trial evaluating ex vivo drug sensitivity testing and multi-omics profiling in pediatric cancers. Recruitment is ongoing ac…

CLINICAL_TRIALS research · 2025-06-26

Clinical Trial Update: Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma [Phase 1]

A Phase 1 clinical trial evaluating mocetinostat in combination with vinorelbine for children, adolescents, and young adults with refractory…

CLINICAL_TRIALS research · 2025-05-02

Clinical Trial Update: Collecting and Storing Tissue From Young Patients With Cancer

A completed clinical trial update from the Children’s Oncology Group describing the collection and storage of tissue from pediatric cancer p…

CLINICAL_TRIALS research · 2025-04-22

Clinical Trial Update: Exploratory Study of Personalized mRNA Vaccine in Patients With Refractory Rhabdomyosarcoma [EARLY_Phase 1]

An exploratory early-phase study evaluating a personalized mRNA vaccine in patients with refractory rhabdomyosarcoma.

CLINICAL_TRIALS research · 2025-04-16

Clinical Trial Update: Doxorubicin Hydrochloride Liposome Combined With Irinotecan (AI Regimen) Versus VIT Regimen in the Treatment of First Relapsed and Refractory Pediatric Rhabdomyosarcoma: a Prospective, Open-label, Randomized Controlled, Multicenter, Phase II Clinical Study [Phase 2]

A Phase II randomized trial in children with first-relapsed and refractory rhabdomyosarcoma compares Doxorubicin liposome plus Irinotecan (A…

CLINICAL_TRIALS research · 2025-04-11

Clinical Trial Update: Identification of Specific Molecular Signatures in Pediatric, Adolescent, and Young Adult Rhabdomyosarcoma Through Spatial Proteome Analysis Using Mass Spectrometry

This clinical trial update notes ongoing recruitment for a study in pediatric, adolescent, and young adult rhabdomyosarcoma using spatial pr…

CLINICAL_TRIALS research · 2025-03-18

Clinical Trial Update: Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO) [NA]

This entry reports on the MICCHADO trial, which investigates the biological characterization of high-risk childhood cancers. The sponsor is …

CLINICAL_TRIALS research · 2025-02-20

Clinical Trial Update: A Prospective Clinical Cohort Study on Stratified Treatment of Rhabdomyosarcoma Based on Risk Factors. [Phase 3]

A Phase 3 prospective cohort trial is evaluating risk-factor-based, stratified treatment for rhabdomyosarcoma and is currently recruiting.

CLINICAL_TRIALS research · 2025-02-12

Clinical Trial Update: Accurate Diagnosis and Grading of Pediatric Solid Tumors Based on Pathological Large Models

A clinical trial from Xinhua Hospital and Shanghai Jiao Tong University aims to improve diagnosis and grading of pediatric solid tumors usin…

CLINICAL_TRIALS research · 2025-02-10

Clinical Trial Update: Evaluation of the Efficacy and Safety of Pazopanib in Combination with TGI/CIV for Recurrent or Refractory Rhabdomyosarcoma in Children or Adolescents [Phase 2]

Phase 2 clinical trial evaluating pazopanib in combination with TGI/CIV for recurrent or refractory rhabdomyosarcoma in children and adolesc…

CLINICAL_TRIALS research · 2025-01-14

Clinical Trial Update: Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors [Phase 2]

Phase 2 pediatric trial evaluating palbociclib in combination with chemotherapy for recurrent or refractory solid tumors, including Ewing sa…

CLINICAL_TRIALS research · 2024-12-20

Clinical Trial Update: Multi-cohort, Single-arm Phase II Study of Albumin-paclitaxel, Ifosfamide, and Cisplatin in the Treatment of Rare Advanced Tumors [Phase 2]

Phase II, multi-cohort, single-arm trial evaluating a triplet regimen of albumin-bound paclitaxel, ifosfamide, and cisplatin in rare advance…

CLINICAL_TRIALS research · 2024-12-13

Clinical Trial Update: Molecular-Functional Imaging of Hypoxia in Childhood Sarcomas [Phase 1]

ClinicalTrials.gov entry describing a Phase 1 study of molecular-functional imaging of hypoxia in childhood sarcomas, currently enrolling by…

CLINICAL_TRIALS research · 2024-12-12

Clinical Trial Update: Personalized Vaccination in Fusion+ Sarcoma Patients (PerVision) [Phase 1, Phase 2]

Phase 1/2 clinical trial update for PerVision, a personalized cancer vaccine for fusion-positive sarcomas, currently recruiting at Universit…

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