Retinitis Pigmentosa
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CLINICAL_TRIALS withdrawal · 2024-10-15Clinical Trial Update: Dose Escalation Study to Evaluate the Safety/Tolerability and Efficacy of EA-2353 in Subjects With Retinitis Pigmentosa [Phase 1, Phase 2]
A dose-escalation trial evaluating the safety, tolerability, and efficacy of EA-2353 in subjects with Retinitis Pigmentosa was terminated (P…
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CLINICAL_TRIALS trial_result · 2024-09-23Clinical Trial Update: Phase 1 Study of Intravitreal Autologous CD34+ Stem Cell Therapy for Retinitis Pigmentosa [Phase 1]
Phase 1 trial evaluating intravitreal autologous CD34+ stem cell therapy for Retinitis Pigmentosa has completed.
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CLINICAL_TRIALS research · 2024-08-23Clinical Trial Update: Longitudinal Study of a Bionic Eye
Clinical trial update for a longitudinal study of a bionic eye, enrolling by invitation to investigate treatment for retinal degenerations.
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CLINICAL_TRIALS trial_result · 2024-08-13Clinical Trial Update: A Study of Encapsulated Cell Technology (ECT) Implant for Patients With Late Stage Retinitis Pigmentosa [Phase 2]
Phase 2 study of the Encapsulated Cell Technology Implant for late-stage Retinitis Pigmentosa has completed. Results have been posted by Neu…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: A New Diagnostic Paradigm for Retinitis Pigmentosa Secondary to USH2A Pathogenic Variants
Clinical trial update describing a new diagnostic paradigm for Retinitis Pigmentosa caused by USH2A pathogenic variants; the study is not ye…
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CLINICAL_TRIALS trial_result · 2024-07-12Clinical Trial Update: Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius) [Phase 2, Phase 3]
The Sirius study evaluating Ultevursen for retinitis pigmentosa due to USH2A exon 13 mutations (Phase 2/3) was terminated, with results post…
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CLINICAL_TRIALS trial_result · 2024-06-20Clinical Trial Update: Natural History Study of Patients With X-linked Retinal Dystrophy Associated With Mutations in Retinitis Pigmentosa GTPase Regulator (RPGR)
This clinical trial update reports the completion of a natural history study in patients with X-linked retinitis pigmentosa associated with …
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CLINICAL_TRIALS trial_result · 2024-05-06Clinical Trial Update: Aflibercept for Macular Oedema With Underlying Retinitis Pigmentosa (AMOUR) Study [Phase 2]
Phase 2 AMOUR trial evaluating aflibercept for macular edema due to underlying retinitis pigmentosa has completed and results were posted in…
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CLINICAL_TRIALS research · 2024-04-25Clinical Trial Update: The Effect of Oral Administration of 9-cis β Carotene Rich Powder of the Alga Dunaliella Bardawil [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial update evaluating oral 9-cis beta-carotene-rich powder from the alga Dunaliella bardawil in individuals wit…
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CLINICAL_TRIALS research · 2024-04-25Clinical Trial Update: Evaluation of Objective Perimetry Using Chromatic Multifocal Pupillometer
The study is evaluating objective perimetry with a chromatic multifocal pupillometer and is currently recruiting at Sheba Medical Center for…
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CLINICAL_TRIALS trial_result · 2024-04-18Clinical Trial Update: PDE6A Gene Therapy for Retinitis Pigmentosa [Phase 1, Phase 2]
Phase 1/2 trial update for PDE6A gene therapy targeting retinitis pigmentosa, indicating ongoing development with active not recruiting stat…
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CLINICAL_TRIALS trial_result · 2024-03-22Clinical Trial Update: Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE] [Phase 2]
Phase 2 trial update on MCO-010 optogenetic therapy for retinitis pigmentosa shows efficacy and safety data collected in adults.
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CLINICAL_TRIALS trial_result · 2023-12-27Clinical Trial Update: Minocycline Treatment in Retinitis Pigmentosa [Phase 2]
Phase 2 trial update on minocycline for retinitis pigmentosa and inherited retinal dystrophy has completed.
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CLINICAL_TRIALS trial_result · 2023-11-28Clinical Trial Update: Interventional Study of Implantation of hESC-derived RPE in Patients With RP Due to Monogenic Mutation [Phase 1, Phase 2]
Interventional study investigating implantation of human embryonic stem cell–derived retinal pigment epithelium (RPE) for retinitis pigmento…
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CLINICAL_TRIALS trial_result · 2023-09-26Clinical Trial Update: Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects With Retinitis Pigmentosa [Phase 2]
Phase 2 clinical trial assessing safety of repeat intravitreal injections of jCell (human retinal progenitor cells) in adults with Retinitis…
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CLINICAL_TRIALS trial_result · 2023-07-06Clinical Trial Update: Safety and Tolerability of hRPC in Retinitis Pigmentosa [Phase 1, Phase 2]
Safety and tolerability data from early-phase trials of hRPC in retinitis pigmentosa are reported, with unknown overall-phase status.
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CLINICAL_TRIALS trial_result · 2023-04-05Clinical Trial Update: Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision [Phase 3]
Phase 3 clinical trial evaluating a combination therapy of Wharton’s Jelly-derived mesenchymal stem cells and Magnovision for retinitis pigm…
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CLINICAL_TRIALS trial_result · 2023-03-08Clinical Trial Update: Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A [Phase 3]
Phase 3 randomized trial evaluating DHA for retinitis pigmentosa patients receiving Vitamin A has completed.
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CLINICAL_TRIALS trial_result · 2023-02-14Clinical Trial Update: Retinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa [Phase 2]
Phase 2 trial update on encapsulated cell implant delivering CNTF for early-stage Retinitis Pigmentosa; results completed and posted.
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CLINICAL_TRIALS trial_result · 2023-02-03Clinical Trial Update: Spheroidal Mesenchymal Stem Cells in Retinitis Pigmentosa [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating spheroidal mesenchymal stem cells for Retinitis Pigmentosa has completed.
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CLINICAL_TRIALS trial_result · 2023-01-20Clinical Trial Update: Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste) [Phase 2, Phase 3]
A Phase 2/3 study evaluating QR-421a for retinitis pigmentosa due to USH2A exon 13 mutations was terminated, with results posted in January …
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CLINICAL_TRIALS trial_result · 2023-01-11Clinical Trial Update: CB-PRP in Retinitis Pigmentosa and Dry Age-related Macular Degeneration [Phase 3]
Phase 3 trial update for CB-PRP in retinitis pigmentosa and dry age-related macular degeneration (AREDS) has been completed.
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CLINICAL_TRIALS trial_result · 2022-12-27Clinical Trial Update: An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa [Phase 2]
A Phase 2 open-label extension study evaluating the safety and tolerability of QR-421a in retinitis pigmentosa and Usher syndrome type 2 was…
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CLINICAL_TRIALS trial_result · 2022-09-07Clinical Trial Update: The Effect of Stem Cells and Stem Cell Exosomes on Visual Functions in Patients With Retinitis Pigmentosa [Phase 2, Phase 3]
A clinical trial update describes a phase 2/3 study assessing the effects of stem cells and stem cell exosomes on visual function in patient…
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CLINICAL_TRIALS trial_result · 2022-04-20Clinical Trial Update: Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene [Phase 1, Phase 2]
Phase 1/2 trial evaluating safety and tolerability of QR-421a in retinitis pigmentosa due to USH2A exon 13 mutations has completed.