Rectal Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-09-08Clinical Trial Update: Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant Therapy for Locally Advanced Rectal Cancer Prior to Surgery: A Prospective, Multi-center, Randomized Controlled Study [Phase 2]
Phase 2 randomized neoadjuvant study evaluating a PD-1 monoclonal antibody in combination with interleukin-2 and CapeOX for locally advanced…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: Ketogenic Diet Compliance in Patients Undergoing Radiotherapy for Pelvic Cancers [NA]
An update on a recruiting clinical trial evaluating compliance with a ketogenic diet in patients undergoing radiotherapy for pelvic cancers,…
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: Phase II RCT of LCRT vs SCRT + CAPOX/PD-1i/COX-2i in MSS Locally Advanced Rectal Cancer [Phase 2]
Phase II randomized trial comparing long-course chemoradiation to short-course radiotherapy with CAPOX, a PD-1 inhibitor, and a COX-2 inhibi…
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT) [Phase 2]
Phase 2 trial evaluating pucotenlimab in combination with radiotherapy and chemotherapy as neoadjuvant treatment for locally advanced rectal…
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: Intraoperative Neuromonitoring of Pelvic Autonomous Nerve Plexus During Total Mesorectal Excision [NA]
A clinical trial exploring intraoperative neuromonitoring of the pelvic autonomic nerve plexus during total mesorectal excision in rectal ca…
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Encorafenib Plus Cetuximab in a Neoadjuvant Setting in Patients With BRAF Mutation Localised Colon or Upper Rectum Cancer [Phase 2]
Phase 2 clinical trial evaluating the combination of encorafenib and cetuximab as neoadjuvant therapy for localized colon or upper rectal ca…
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibitor for MSS Locally Advanced Rectal Cancer (SERRAC) [Phase 2]
Phase 2 trial evaluating either long-course chemoradiotherapy or short-course radiotherapy combined with CAPOX, a PD-1 antibody, and a COX-2…
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer [NA]
This clinical trial update describes a Nordic organ preservation pilot for rectal cancer using non-operative management. It is a nonrandomis…
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CLINICAL_TRIALS research · 2025-08-29Clinical Trial Update: Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers [Phase 2]
Phase 2 clinical trial comparing time-restricted eating versus nutritional counseling to reduce radiation- or chemoradiation-related side ef…
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CLINICAL_TRIALS trial_result · 2025-08-28Clinical Trial Update: Trial of Capecitabine With or Without Irinotecan Driven by UGT1A1 [Phase 3]
A Phase 3 trial evaluating capecitabine with or without irinotecan in locally advanced rectal cancer has been completed, with study driven b…
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CLINICAL_TRIALS trial_result · 2025-08-28Clinical Trial Update: Low Powered Colorectal Anastomosis After Rectal Excision (OASIS)
Clinical trial update for the OASIS study evaluating a low powered colorectal anastomosis after rectal excision. The trial is currently not …
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer [Phase 2]
A Phase 2 trial is evaluating SCRT sequential Penpulimab with CAPEOX as neoadjuvant therapy for locally advanced rectal cancer and is curren…
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CLINICAL_TRIALS withdrawal · 2025-08-28Clinical Trial Update: Effect of ICCAUT Strategy on Postoperative Urinary Retention After Radical Rectal Cancer Surgery (ICCAUT-2) [NA]
The ICCAUT-2 trial examining a strategy to prevent postoperative urinary retention after radical rectal cancer surgery has been withdrawn.
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CLINICAL_TRIALS research · 2025-08-27Clinical Trial Update: Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management [Phase 2]
This Phase 2 trial update investigates 3-year disease-free survival in locally advanced rectal cancer patients treated with chemoradiation a…
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CLINICAL_TRIALS research · 2025-08-27Clinical Trial Update: A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer. [Phase 2]
This Phase I-II trial evaluates the safety and preliminary efficacy of AB122 (PD-1 antagonist) and AB928 (adenosine receptor antagonist) in …
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CLINICAL_TRIALS research · 2025-08-22Clinical Trial Update: The Effect of Art Therapy in Patients Undergoing Colorectal Cancer [NA]
Clinical trial update examining the impact of art therapy for patients undergoing colorectal cancer; currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-08-21Clinical Trial Update: Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer [Phase 2, Phase 3]
A Phase 2/Phase 3 trial is evaluating neoadjuvant chemoradiotherapy combined with immunotherapy and anti-angiogenesis for locally advanced r…
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CLINICAL_TRIALS research · 2025-08-21Clinical Trial Update: Magnetic Resonance Imaging (MRI)-Guided Rectal Cancer Preservation Program [NA]
A ClinicalTrials.gov update describes an MRI-guided rectal cancer preservation trial led by Clinica Universidad de Navarra/Universidad de Na…
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CLINICAL_TRIALS research · 2025-08-20Clinical Trial Update: Preoperative Short-Course Radiation Therapy With PROtons Compared to Photons In High-Risk RECTal Cancer (PRORECT) [NA]
The PRORECT trial is evaluating preoperative short-course radiation therapy using proton beam therapy versus photon beam therapy in high-ris…
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CLINICAL_TRIALS other · 2025-08-20Clinical Trial Update: Neoadjuvant Chemoradiotherapy Followed by Chemotherapy With or Without Tislelizumab for Resectable Ultra-low Rectal Cancer: The RELIEVE-02 Study [Phase 3]
Phase 3 RELIEVE-02 trial evaluating neoadjuvant chemoradiotherapy with or without tislelizumab for resectable ultra-low rectal cancer; curre…
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Transanal Total Mesorectal Excision for Rectal Cancer on Anal Physiology + Fecal Incontinence
A clinical trial update on transanal total mesorectal excision for rectal cancer assessing effects on anal physiology and fecal incontinence…
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: Modified SCRT Followed by Tislelizumab Plus CAPOX for Locally Advanced Rectal Cancer [Phase 2]
A Phase 2 trial evaluating modified short-course radiotherapy followed by tislelizumab plus CAPOX for locally advanced rectal cancer has com…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Stigma and Psychological profilE in REctal-anal caNcer pAtients
A clinical trial assessing stigma and psychological profiles in patients with rectal or anal cancer is currently recruiting. The study is sp…
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CLINICAL_TRIALS trial_result · 2025-08-14Clinical Trial Update: Deep Learning Based MRI Radiomics in Predicting the Clinical Risk of Locally Advanced Rectal Cancer
A completed clinical trial assessing deep learning-based MRI radiomics for predicting clinical risk in locally advanced rectal cancer.
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CLINICAL_TRIALS trial_result · 2025-08-14Clinical Trial Update: Feasibility of the Maastro Applicator in Rectal Cancer [NA]
This clinical trial update notes an active-not-recruiting study assessing the feasibility of the Maastro Applicator for rectal cancer, with …