Rectal Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RC [Phase 3]
Phase 3 trial evaluating short-course radiotherapy plus chemotherapy and targeted immunotherapy as a neoadjuvant strategy for high-risk pMMR…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Stereotactic Body Radiation Therapy for Unresectable Locally Recurrent Rectal Cancer [Phase 2]
Phase 2 study evaluating stereotactic body radiation therapy for unresectable locally recurrent rectal cancer; recruitment is ongoing.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Node-sparing Radiotherapy Combined With Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer [Phase 2]
Phase 2 trial evaluating node-sparing radiotherapy combined with total neoadjuvant CAPOX chemotherapy and sintilimab for microsatellite-stab…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Watch and Wait Management on Rectal Cancer Patients Using New Swift Local Therapy [NA]
Clinical trial update on watch-and-wait management for rectal cancer using a new swift local therapy. The trial is currently suspended.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: SCRT Based iTNT vs. LCRT Based TNT for MSS Locally Advanced Rectal Cancer [Phase 3]
This Phase 3 trial compares SCRT-based iTNT with LCRT-based TNT for microsatellite-stable locally advanced rectal cancer and is not yet recr…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer
This clinical trial update describes an investigation of ctDNA-guided organ preservation and pathologic complete response in non-metastatic …
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Study on the Accurate Evaluation of Pseudoprogression of Rectal Cancer Immunotherapy Based on Multitemporal and Multiparameter MRI
An ongoing clinical trial evaluating methods to accurately distinguish pseudoprogression in rectal cancer patients treated with immunotherap…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Predicting the Efficacy of Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer Using an AI Platform Based on Multi-parametric MRI
This clinical trial investigates whether an AI platform based on multi-parametric MRI can predict the efficacy of neoadjuvant therapy in loc…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Pilot Study Evaluating β-hydroxybutyrate Supplementation Concomitant to Short-Course Radiotherapy Followed by Immunotherapy Combined With CAPEOX Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer [Phase 2]
Phase 2 pilot study evaluating beta-hydroxybutyrate supplementation with radiotherapy followed by immunotherapy and CAPEOX neoadjuvant thera…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: SBRT + PD-1 Antibody in Unresectable Locally Recurrent Rectal Cancer（SPARKLE） [Phase 2]
Phase 2 clinical trial investigating the combination of stereotactic body radiotherapy (SBRT) with a PD-1 antibody in unresectable locally r…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course Radiotherapy, and XELOX Chemotherapy as Total Neoadjuvant Treatment for Locally Advanced (cT1-3N0M0) Rectal Cancer [Phase 2]
Prospective Phase II single-arm study evaluating serplulimab with H101 oncolytic virus, short-course radiotherapy, and XELOX as total neoadj…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Contrast-Enhanced Photon-Counting Detector CT (PCD-CT) for the Local Staging of Rectal Cancer
A Mayo Clinic-sponsored clinical trial is evaluating contrast-enhanced photon-counting detector CT for local staging of rectal cancer and is…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Supportive Oncology Care At Home RCT [NA]
Clinical trial update on an at-home supportive oncology care program; the study is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Application and Exploration of Personalized ctDNA-MRD Detection Technology in Predicting the Efficacy of Neoadjuvant Therapy for Rectal Cancer
This clinical trial analyzes personalized ctDNA minimal residual disease detection to predict the efficacy of neoadjuvant therapy in locally…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation [Phase 2]
A Phase 2 trial evaluating adding nivolumab to standard therapy for patients with metastatic or unresectable colorectal cancer with a BRAF m…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients [NA]
Clinical trial update indicates recruitment for a bowel management program using retrograde rectal enema to treat Low Anterior Resection Syn…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer [Phase 2]
Phase 2 study evaluating atezolizumab with or without tiragolumab after neoadjuvant chemoradiotherapy in locally advanced rectal cancer; cur…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer [Phase 2]
A Phase 2 clinical trial evaluating vaginal DHEA to improve vaginal health after radiation in women with gynecologic, anal, or rectal cancer…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Optimization and Standardization of Single-Port Robotic Transanal Minimally Invasive Surgery for Rectal Tumor Excision [NA]
This clinical trial update reports ongoing optimization and standardization of a single-port robotic transanal minimally invasive surgery ap…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Diagnostic Accuracy and Prognostic Value of 18F FDG PET-CT in the Follow up of Patients With Colorectal Carcinoma.
A clinical trial evaluating the diagnostic accuracy and prognostic value of 18F-FDG PET-CT in the follow-up of patients with colorectal canc…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial. [Phase 2, Phase 3]
This is a clinical trial update for a randomized controlled study evaluating antegrade intestinal fluid reinfusion to prevent Low Anterior R…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Lenvatinib and Pembrolizumab to Treat Patients With Anal or Rectum Cancer That Has Gotten Worse After Initial Treatment [Phase 2]
Clinical trial update announcing a phase 2 study of lenvatinib in combination with pembrolizumab for anal or rectal cancer that progressed a…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary [NA]
This clinical trial focuses on developing an electronic diary and personalized care pathways to address bowel symptoms in rectal cancer pati…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Metabolomics to Predict Treatment Response and Toxicities in Rectal Cancer
A clinical trial evaluating metabolomics as a predictor of treatment response and toxicities in rectal cancer. Sponsored by Chang Gung Memor…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Multicenter Phase II Study of Transanal TME (taTME) [NA]
A multicenter Phase II study is evaluating transanal total mesorectal excision (taTME) for rectal cancer; the trial is currently active but …