Pure Autonomic Failure
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-08-07Clinical Trial Results: Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients [EARLY_Phase 1]
Early-phase trial comparing midodrine to abdominal compression in autonomic failure patients assessing cardiovascular risk markers.
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: CPAP for the Treatment of Supine Hypertension [NA]
This clinical trial update indicates that a study is recruiting to evaluate CPAP for the treatment of supine hypertension in autonomic failu…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: [18F]F-DOPA Imaging in Patients With Autonomic Failure [Phase 1]
Phase 1 imaging trial of [18F]F-DOPA in autonomic failure syndromes (including Parkinson's disease, multiple system atrophy, and dementia wi…
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CLINICAL_TRIALS other · 2026-01-16Clinical Trial Update: Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension [NA]
Ongoing clinical trial assessing overnight heat-stress effects in autonomic failure patients with supine hypertension; recruitment is curren…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients [EARLY_Phase 1]
A Phase 1 clinical trial is evaluating midodrine versus abdominal compression for cardiovascular risk markers in autonomic failure, and the …
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure [Phase 1]
This Phase 1 trial evaluates whether abdominal compression can modify hemodynamics to treat orthostatic hypotension in autonomic failure and…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Automated Abdominal Binder for Orthostatic Hypotension [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating an automated abdominal binder to treat orthostatic hypotension is currently recruiting.
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure [Phase 1]
Phase 1 clinical trial evaluating the effects of midodrine and droxidopa on splanchnic capacitance in autonomic failure; currently recruitin…
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CLINICAL_TRIALS trial_result · 2025-09-19Clinical Trial Update: Biomarkers of Risk of Parkinson Disease
An update on a completed trial investigating biomarkers linked to future risk of Parkinson's disease.
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms [NA]
This clinical trial update describes a Vanderbilt-led study evaluating accelerometer-based quantification of symptoms in neurogenic orthosta…
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CLINICAL_TRIALS research · 2025-06-11Clinical Trial Update: Natural History Study of Synucleinopathies
An update on an ongoing natural history study of synucleinopathies, currently recruiting participants, including Parkinson's disease and rel…
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CLINICAL_TRIALS withdrawal · 2023-01-20Clinical Trial Update: Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure [Phase 3]
Phase 3 trial of TD-9855 for symptomatic neurogenic orthostatic hypotension was terminated; results were posted in 2023.
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CLINICAL_TRIALS trial_result · 2022-09-26Clinical Trial Update: TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) [Phase 2]
Phase 2 clinical trial update for TD-9855 in neurogenic orthostatic hypotension (nOH) completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-03-10Clinical Trial Update: Local Heat Stress in Autonomic Failure Patients With Supine Hypertension [NA]
Clinical trial about local heat stress in autonomic failure patients with supine hypertension has completed; results posted.
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CLINICAL_TRIALS trial_result · 2018-03-01Clinical Trial Update: The Autonomic Nervous System and Obesity [Phase 1]
Phase 1 clinical trial update examining the autonomic nervous system's role in obesity, with related conditions including hypertension, pure…
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CLINICAL_TRIALS research · 2017-01-18Clinical Trial Update: Magnetic Resonance Spectroscopy in Autonomic Failure
The Vanderbilt University–sponsored study using magnetic resonance spectroscopy to investigate autonomic failure has been terminated. The co…
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CLINICAL_TRIALS trial_result · 2017-01-06Clinical Trial Update: Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension
A completed clinical trial evaluated norepinephrine transporter blockade as a pathological biomarker in neurogenic orthostatic hypotension a…
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CLINICAL_TRIALS research · 2016-10-18Clinical Trial Update: Autonomic Failure Patients for RNA Blood Sampling
A Vanderbilt University-led clinical trial completed its RNA blood sampling study in autonomic failure patients, including Pure Autonomic Fa…
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CLINICAL_TRIALS trial_result · 2016-01-08Clinical Trial Update: A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy [Phase 3]
Phase 3 study of droxidopa in symptomatic neurogenic orthostatic hypotension, including participants with Parkinson's disease, multiple syst…
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CLINICAL_TRIALS trial_result · 2015-05-01Clinical Trial Update: Nebivolol in the Supine Hypertension of Autonomic Failure [NA]
Clinical trial update shows a completed study of Nebivolol for supine hypertension in autonomic failure with results posted in 2015.
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CLINICAL_TRIALS trial_result · 2010-05-03Clinical Trial Update: Nitric Oxide and the Autonomic Nervous System [NA]
A Vanderbilt University clinical trial studied nitric oxide's effects on the autonomic nervous system in individuals with hypertension and p…