Prolymphocytic Leukemia

• CLINICAL_TRIALS research · 2026-03-17
  Clinical Trial Update: A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation [Phase 2]

  This Phase 2 clinical trial protocol investigates a post-transplant cyclophosphamide–based graft-versus-host disease prophylaxis approach in…

• CLINICAL_TRIALS trial_result · 2025-12-19
  Clinical Trial Update: Acalabrutinib in Combination With Anti-CD20 and Venetoclax in Relapsed/Refractory or Untreated CLL/SLL/PLL [Phase 1]

  Phase 1 trial evaluating acalabrutinib with anti-CD20 therapy and venetoclax in relapsed/refractory or untreated chronic lymphocytic leukemi…

• CLINICAL_TRIALS trial_result · 2025-12-15
  Clinical Trial Update: Phase II MOR00208 in Combination With Lenalidomide for Patients With Relapsed or Refractory CLL, SLL or PLL or Older Patients With Untreated CLL, SLL or PLL [Phase 2]

  An update on a Phase II trial evaluating MOR00208 in combination with lenalidomide for relapsed/refractory or untreated older patients with …

• CLINICAL_TRIALS research · 2025-11-26
  Clinical Trial Update: Observatory of Prolymphocytic Leukemia T

  This is a clinical trial registry entry for an ongoing study on prolymphocytic leukemia of T-cell origin, with recruitment currently ongoing…

• CLINICAL_TRIALS research · 2025-11-06
  Clinical Trial Update: Ibrutinib With or Without Rituximab in Treating Patients With Relapsed Chronic Lymphocytic Leukemia [Phase 2]

  A Phase 2 trial is evaluating ibrutinib with or without rituximab in patients with relapsed chronic lymphocytic leukemia and related lymphop…

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• CLINICAL_TRIALS trial_result · 2025-06-10
  Clinical Trial Update: Selinexor and Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Aggressive Non-Hodgkin Lymphoma [Phase 1]

  Phase 1 trial of selinexor in combination with ibrutinib for relapsed or refractory chronic lymphocytic leukemia and aggressive non-Hodgkin …

• CLINICAL_TRIALS trial_result · 2023-09-21
  Clinical Trial Update: Allo HSCT Using RIC for Hematological Diseases [Phase 2]

  Phase 2 trial evaluating allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning for various hematologic dise…

• CLINICAL_TRIALS trial_result · 2022-11-03
  Clinical Trial Update: Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies [Phase 2]

  Phase 2 clinical trial update on shorter course tacrolimus after non-myeloablative conditioning with related donor PBSCT and high-dose postt…

• CLINICAL_TRIALS trial_result · 2022-09-10
  Clinical Trial Update: ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia [Phase 1, Phase 2]

  ACP-196 (acalabrutinib), a BTK inhibitor, is being studied in Phase 1/2 trials for chronic lymphocytic leukemia, Richter's syndrome, small l…

• CLINICAL_TRIALS trial_result · 2020-09-10
  Clinical Trial Update: Myeloablative Umbilical Cord Blood Transplantation in Hematological Diseases [Phase 2]

  Phase 2 trial evaluating myeloablative umbilical cord blood transplantation in various hematological diseases has completed with results pos…

• CLINICAL_TRIALS trial_result · 2020-02-10
  Clinical Trial Update: Allogeneic Stem Cell Transplant for CLL [Phase 1, Phase 2]

  A phase 1/2 clinical trial evaluating allogeneic hematopoietic stem cell transplantation for chronic lymphocytic leukemia and related diseas…

• CLINICAL_TRIALS trial_result · 2019-11-22
  Clinical Trial Update: Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological Malignancies [Phase 2]

  Phase 2 clinical trial assessing donor atorvastatin to prevent severe acute GVHD after nonmyeloablative peripheral blood stem cell transplan…

• CLINICAL_TRIALS trial_result · 2019-07-11
  Clinical Trial Update: Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 2]

  Phase 2 clinical trial evaluating fludarabine phosphate, radiation therapy, and rituximab followed by rituximab maintenance in high-risk chr…

• CLINICAL_TRIALS trial_result · 2019-05-21
  Clinical Trial Update: PCI-32765 (Ibrutinib) in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-cell Prolymphocytic Leukemia [Phase 2]

  Phase 2 results for Ibrutinib (PCI-32765) in relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lymphoma, and B-cell pro…

• CLINICAL_TRIALS trial_result · 2019-04-17
  Clinical Trial Update: Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22 [Phase 1, Phase 2]

  Phase 1/2 clinical trial evaluating tandem CAR T cells targeting CD19 and CD22 for relapsed or chemotherapy-refractory B-cell malignancies.

• CLINICAL_TRIALS trial_result · 2018-05-11
  Clinical Trial Update: Combination Chemotherapy Followed By Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia [Phase 2]

  A Phase 2 trial evaluating chemotherapy followed by Alemtuzumab for chronic lymphocytic leukemia or prolymphocytic leukemia has completed.

• CLINICAL_TRIALS trial_result · 2018-03-15
  Clinical Trial Update: Ofatumumab and Dinaciclib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-Cell Prolymphocytic Leukemia [Phase 1, Phase 2]

  This clinical trial update reports completed Phase 1/Phase 2 studies evaluating the combination of ofatumumab and dinaciclib in patients wit…

• CLINICAL_TRIALS trial_result · 2017-12-07
  Clinical Trial Update: Autologous Stem Cell Transplant Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoma [Phase 1, Phase 2]

  Phase 1/2 clinical trial evaluating autologous stem cell transplant followed by donor stem cell transplant in relapsed or refractory lymphom…

• CLINICAL_TRIALS trial_result · 2017-04-12
  Clinical Trial Update: A Phase I, Multicenter, Dose Escalation Study of CAT-8015 in Participants With Chronic Leukemia [Phase 1]

  A Phase I dose-escalation study of CAT-8015 (moxetumomab pasudotox) in participants with chronic leukemia; the trial was terminated and resu…

• CLINICAL_TRIALS withdrawal · 2017-04-05
  Clinical Trial Update: Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's Transformation [Phase 2]

  This clinical trial update reports that the Phase 2 study of Sotrastaurin acetate for relapsed or refractory chronic lymphocytic leukemia, s…

• CLINICAL_TRIALS trial_result · 2017-03-21
  Clinical Trial Update: Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant [Phase 2]

  Phase 2 study evaluating lenalidomide with or without rituximab in patients with relapsed or progressive chronic lymphocytic leukemia, small…

• CLINICAL_TRIALS trial_result · 2016-10-24
  Clinical Trial Update: Flavopiridol in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia [Phase 2]

  This Phase 2 clinical trial evaluated flavopiridol in patients with chronic lymphocytic leukemia and prolymphocytic leukemia; the study was …

• CLINICAL_TRIALS trial_result · 2016-09-26
  Clinical Trial Update: Fludarabine, Cyclophosphamide, and Rituximab in Treating Patients With Prolymphocytic Leukemia [Phase 2]

  A Phase 2 trial evaluating fludarabine, cyclophosphamide, and rituximab in patients with prolymphocytic leukemia has been terminated.

• CLINICAL_TRIALS trial_result · 2016-05-09
  Clinical Trial Update: Study of Carfilzomib in Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL) [Phase 1]

  Phase 1 study of carfilzomib in patients with chronic lymphocytic leukemia, small lymphocytic lymphoma, or prolymphocytic leukemia has compl…

• CLINICAL_TRIALS research · 2016-01-28
  Clinical Trial Update: Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by CART19 [NA]

  Clinical trial update describing CART19 therapy for relapsed and/or chemotherapy-refractory B-cell malignancies with an unknown status of th…