Progressive Multifocal Leukoencephalopathy
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study [Phase 2]
A Phase 2 clinical trial evaluating intravenous brincidofovir for progressive multifocal leukoencephalopathy is currently not yet recruiting…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
This update indicates that a natural history study of Progressive Multifocal Leukoencephalopathy (PML) is currently recruiting, sponsored by…
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy [Phase 1]
Phase 1 clinical trial investigating the central nervous system uptake of anti-CD8+ T cell minibodies for multiple sclerosis and progressive…
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CLINICAL_TRIALS trial_result · 2026-04-06Clinical Trial Update: Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells [EARLY_Phase 1]
An early-phase trial evaluates adoptive transfer of ex vivo generated polyomavirus-specific T-cells to treat progressive multifocal leukoenc…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Observational Cohort Study of Chronic Viral Infection in the Central Nervous System
This clinical trial update reports on an observational cohort study sponsored by Peking Union Medical College Hospital to examine chronic vi…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy (ANRS125) [Phase 2]
A Phase 2 study evaluating early intensification of antiretroviral therapy including enfuvirtide for HIV-related progressive multifocal leuk…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: T-cell Therapy in Patients With PML [Phase 2]
Phase 2 clinical trial evaluating a T-cell therapy for Progressive Multifocal Leukoencephalopathy is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-31Clinical Trial Update: Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy [NA]
This clinical trial update describes a completed study examining how T cells express immune checkpoint molecules in Progressive Multifocal L…
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CLINICAL_TRIALS trial_result · 2025-11-18Clinical Trial Update: NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy [EARLY_Phase 1]
This clinical trial update reports the completed early-phase 1 study of NT-I7 (long-acting recombinant interleukin-7) as an immune reconstit…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Observational Study on Characteristics and Survival Correlates of Progressive Multifocal Leukoencephalopathy (PML) in Italy
A completed Italian observational study analyzed patient characteristics and survival correlates in Progressive Multifocal Leukoencephalopat…
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CLINICAL_TRIALS trial_result · 2024-02-26Clinical Trial Update: Pembrolizumab in Progressive Multifocal Leukoencephalopathy (PML) in Immunocompromised Patients Without HIV Infection [Phase 2, Phase 3]
A clinical trial evaluating pembrolizumab for progressive multifocal leukoencephalopathy in immunocompromised patients without HIV infection…
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CLINICAL_TRIALS trial_result · 2022-09-16Clinical Trial Update: A Phase 2 Study Evaluating JCPyV-specific T Cell Therapy for PML [Phase 2]
Phase 2 study evaluating JCPyV-specific T cell therapy for Progressive Multifocal Leukoencephalopathy is in early results with unknown statu…
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CLINICAL_TRIALS trial_result · 2021-11-01Clinical Trial Update: Comparison of Anti HIV Drugs Used Alone or in Combination With Cytosine Arabinoside to Treat Progressive Multifocal Leukoencephalopathy (PML) in HIV-Infected Patients [Phase 2]
Phase 2 clinical trial evaluating anti-HIV drugs alone or with cytosine arabinoside for progressive multifocal leukoencephalopathy in HIV-in…
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CLINICAL_TRIALS trial_result · 2019-09-20Clinical Trial Update: Treatment of PD-1 Inhibitor in AIDS-associated PML [Phase 2]
Phase 2 clinical trial evaluating a PD-1 inhibitor for AIDS-associated Progressive Multifocal Leukoencephalopathy (PML).
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CLINICAL_TRIALS research · 2016-09-09Clinical Trial Update: Retrospective Study of the Survival of Patients Suffering From Hiv-related Progressive Multifocal Leukoencephalopathy
This document reports a retrospective study examining survival outcomes in patients with HIV-related progressive multifocal leukoencephalopa…
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EMA guidance · 2016-02-12Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri
The EMA published updated recommendations to minimize the risk of progressive multifocal leukoencephalopathy (PML) associated with Tysabri (…
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CLINICAL_TRIALS trial_result · 2016-01-29Clinical Trial Update: JC Virus Reactivation in Multiple Sclerosis
This update from a clinical trial discusses JC virus reactivation in people with multiple sclerosis, noting the potential risk of progressiv…
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EMA guidance · 2015-12-18New recommendations to minimise risks of the rare brain infection PML and a type of skin cancer with Gilenya
EMA offers new recommendations to minimize risks of progressive multifocal leukoencephalopathy (PML) and a type of skin cancer associated wi…
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CLINICAL_TRIALS trial_result · 2015-01-19Clinical Trial Update: Genetic Evaluation of Natalizumab-Treated Patients With Progressive Multifocal Leukoencephalopathy
An update on a terminated clinical trial evaluating genetic factors in natalizumab-treated patients with progressive multifocal leukoencepha…
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CLINICAL_TRIALS trial_result · 2014-08-13Clinical Trial Update: Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) [Phase 4]
Phase 4 trial evaluating corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) was terminated; results were posted in 2014.
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CLINICAL_TRIALS trial_result · 2014-07-31Clinical Trial Update: Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML) [Phase 1, Phase 2]
A Biogen-sponsored Phase 1/2 trial evaluating mefloquine for Progressive Multifocal Leukoencephalopathy was terminated, with results posted …
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EMA research · 2011-07-28Identifying research priorities for the study of drug-related progressive multifocal leukoencephalopathy (PML)
EMA identifies research priorities to study drug-related progressive multifocal leukoencephalopathy (PML) to better understand risks and man…
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EMA guidance · 2011-02-05Expressions of interest invited for transatlantic workshop on drug-related PML
EMA invites expressions of interest to participate in a transatlantic workshop focused on drug-related progressive multifocal leukoencephalo…
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EMA safety_alert · 2010-01-21European Medicines Agency recommends additional measures to better manage risk of progressive multifocal leukoencephalopathy (PML) with Tysabri
EU regulators recommend extra measures to better manage the risk of progressive multifocal leukoencephalopathy (PML) with Tysabri (natalizum…
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CLINICAL_TRIALS research · 2009-03-17Clinical Trial Update: Genetics of Progressive Multifocal Leukoencephalopathy and Acquired Immunodeficiency Syndrome
This completed National Cancer Institute study investigates genetic factors related to progressive multifocal leukoencephalopathy and AIDS.