Progressive Multifocal Leukoencephalopathy

• CLINICAL_TRIALS trial_result · 2026-04-24
  Clinical Trial Update: Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study [Phase 2]

  A Phase 2 clinical trial evaluating intravenous brincidofovir for progressive multifocal leukoencephalopathy is currently not yet recruiting…

• CLINICAL_TRIALS trial_result · 2026-04-08
  Clinical Trial Update: Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy [Phase 1]

  Phase 1 clinical trial investigating the central nervous system uptake of anti-CD8+ T cell minibodies for multiple sclerosis and progressive…

• CLINICAL_TRIALS trial_result · 2026-04-06
  Clinical Trial Update: Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells [EARLY_Phase 1]

  An early-phase trial evaluates adoptive transfer of ex vivo generated polyomavirus-specific T-cells to treat progressive multifocal leukoenc…

• CLINICAL_TRIALS trial_result · 2026-04-02
  Clinical Trial Update: Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy (ANRS125) [Phase 2]

  A Phase 2 study evaluating early intensification of antiretroviral therapy including enfuvirtide for HIV-related progressive multifocal leuk…

• CLINICAL_TRIALS trial_result · 2025-12-31
  Clinical Trial Update: Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy [NA]

  This clinical trial update describes a completed study examining how T cells express immune checkpoint molecules in Progressive Multifocal L…

• Want full summaries, importance scores, and drug timelines? Upgrade to Plus or Pro.
• CLINICAL_TRIALS trial_result · 2025-11-18
  Clinical Trial Update: NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy [EARLY_Phase 1]

  This clinical trial update reports the completed early-phase 1 study of NT-I7 (long-acting recombinant interleukin-7) as an immune reconstit…

• CLINICAL_TRIALS trial_result · 2024-09-19
  Clinical Trial Update: Observational Study on Characteristics and Survival Correlates of Progressive Multifocal Leukoencephalopathy (PML) in Italy

  A completed Italian observational study analyzed patient characteristics and survival correlates in Progressive Multifocal Leukoencephalopat…

• CLINICAL_TRIALS trial_result · 2024-02-26
  Clinical Trial Update: Pembrolizumab in Progressive Multifocal Leukoencephalopathy (PML) in Immunocompromised Patients Without HIV Infection [Phase 2, Phase 3]

  A clinical trial evaluating pembrolizumab for progressive multifocal leukoencephalopathy in immunocompromised patients without HIV infection…

• CLINICAL_TRIALS trial_result · 2022-09-16
  Clinical Trial Update: A Phase 2 Study Evaluating JCPyV-specific T Cell Therapy for PML [Phase 2]

  Phase 2 study evaluating JCPyV-specific T cell therapy for Progressive Multifocal Leukoencephalopathy is in early results with unknown statu…

• CLINICAL_TRIALS trial_result · 2021-11-01
  Clinical Trial Update: Comparison of Anti HIV Drugs Used Alone or in Combination With Cytosine Arabinoside to Treat Progressive Multifocal Leukoencephalopathy (PML) in HIV-Infected Patients [Phase 2]

  Phase 2 clinical trial evaluating anti-HIV drugs alone or with cytosine arabinoside for progressive multifocal leukoencephalopathy in HIV-in…

• CLINICAL_TRIALS trial_result · 2019-09-20
  Clinical Trial Update: Treatment of PD-1 Inhibitor in AIDS-associated PML [Phase 2]

  Phase 2 clinical trial evaluating a PD-1 inhibitor for AIDS-associated Progressive Multifocal Leukoencephalopathy (PML).

• CLINICAL_TRIALS trial_result · 2016-01-29
  Clinical Trial Update: JC Virus Reactivation in Multiple Sclerosis

  This update from a clinical trial discusses JC virus reactivation in people with multiple sclerosis, noting the potential risk of progressiv…

• CLINICAL_TRIALS trial_result · 2015-01-19
  Clinical Trial Update: Genetic Evaluation of Natalizumab-Treated Patients With Progressive Multifocal Leukoencephalopathy

  An update on a terminated clinical trial evaluating genetic factors in natalizumab-treated patients with progressive multifocal leukoencepha…

• CLINICAL_TRIALS trial_result · 2014-08-13
  Clinical Trial Update: Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) [Phase 4]

  Phase 4 trial evaluating corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) was terminated; results were posted in 2014.

• CLINICAL_TRIALS trial_result · 2014-07-31
  Clinical Trial Update: Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML) [Phase 1, Phase 2]

  A Biogen-sponsored Phase 1/2 trial evaluating mefloquine for Progressive Multifocal Leukoencephalopathy was terminated, with results posted …

• CLINICAL_TRIALS trial_result · 2007-10-02
  Clinical Trial Update: A Study of ddI in Patients With AIDS Who Become Sicker While Taking Zidovudine [NA]

  An update on a clinical trial evaluating didanosine (ddI) in patients with HIV infection who worsened while taking Zidovudine; the study has…