Central Nervous System Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) [Phase 3]
A Phase 3 trial (IGNITE) comparing tirabrutinib against Rituximab/Temozolomide for relapsed/refractory primary central nervous system lympho…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies [Phase 1]
NX-5948 is being studied in a Phase 1 trial for adults with relapsed/refractory B-cell malignancies; the study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-19Clinical Trial Update: Trial for Patients With Newly Diagnosed Primary Central Nervous System (CNS) Lymphoma [Phase 2]
This update reports results from a Phase 2 trial for newly diagnosed primary central nervous system lymphoma conducted by IELSG; the trial i…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: OptiMATe: De-escalated Induction Treatment in Primary CNS Lymphoma [Phase 3]
Clinical trial update for the Phase 3 OptiMATe study evaluating de-escalated induction treatment in primary central nervous system lymphoma;…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Acalabrutinib and Durvalumab in Primary and Secondary Central Nervous System Lymphoma [Phase 1]
Phase 1 clinical trial evaluating acalabrutinib in combination with durvalumab for patients with central nervous system lymphoma (primary an…
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CLINICAL_TRIALS trial_result · 2026-02-09Clinical Trial Update: Copanlisib With Ibrutinib for Patients With Recurrent/ Refractory Primary Central Nervous System Lymphoma (PCNSL) [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating the combination of copanlisib and ibrutinib in patients with refractory or recurrent primary central n…
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CLINICAL_TRIALS trial_result · 2026-02-02Clinical Trial Update: Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Patients With Newly Diagnosed or Refractory/Recurrent Primary Central Nervous System Lymphoma (PCNSL) and Refractory/Recurrent Secondary Central Nervous System Lymphoma (SCNSL) [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating the BTK inhibitor ibrutinib in adults with newly diagnosed or relapsed/refractory primary CNS lymphoma…
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CLINICAL_TRIALS trial_result · 2026-01-29Clinical Trial Update: Ibrutinib With Rituximab and Lenalidomide for Patients With Recurrent/Refractory Primary or Secondary Central Nervous System Lymphoma (PCNSL/SCNSL) [Phase 1]
Phase 1 study evaluating the combination of ibrutinib, rituximab, and lenalidomide in patients with recurrent/refractory primary central ner…
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: Combination Chemotherapy With or Without Autologous Stem Cell Transplant in Treating Patients With Central Nervous System B-Cell Lymphoma [Phase 2]
Phase 2 clinical trial evaluating combination chemotherapy with or without autologous stem cell transplant for primary central nervous syste…
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CLINICAL_TRIALS trial_result · 2026-01-09Clinical Trial Update: Tisagenlecleucel In Primary CNS Lymphoma [Phase 1]
This update covers a Phase 1 study of tisagenlecleucel in primary central nervous system lymphoma, including refractory/relapsed cases, whic…
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CLINICAL_TRIALS trial_result · 2026-01-06Clinical Trial Update: Pharmacogenomics Effects on High-Dose Methotrexate Clearance in Patients With Diffuse Large B-Cell Lymphoma
This trial update reports on pharmacogenomics effects on the clearance of high-dose methotrexate in patients with diffuse large B-cell lymph…
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CLINICAL_TRIALS trial_result · 2025-12-30Clinical Trial Update: Nivolumab Consolidation in Older (≥ 65) Patients With Primary CNS Lymphoma [Phase 1]
A Phase 1 trial evaluating nivolumab as consolidation therapy in older adults (≥65) with primary central nervous system lymphoma has complet…
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CLINICAL_TRIALS trial_result · 2025-12-24Clinical Trial Update: Preliminary Safety and Tolerability of CD19x22 CAR T Cells in Adolescent and Adult R/R B-NHL Patients [Phase 1]
Phase 1 study assessing safety and tolerability of CD19x22 CAR T cells in adolescents and adults with relapsed/refractory B-cell non-Hodgkin…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: Loncastuximab Tesirine and Rituximab Following Stereotactic Radiosurgery in Patients With Central Nervous System Lymphomas (SOLAR) [Phase 1]
Phase 1 trial SOLAR is evaluating loncastuximab tesirine in combination with rituximab following stereotactic radiosurgery for central nervo…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Glofitamab With Obinutuzumab Pre-treatment for the Treatment of Central Nervous System Lymphoma [Phase 1]
A phase 1 clinical trial is evaluating glofitamab with obinutuzumab pre-treatment for primary or secondary central nervous system lymphoma, …
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CLINICAL_TRIALS trial_result · 2025-10-01Clinical Trial Update: CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial [Phase 2]
This Phase IIc randomized feasibility pilot trial evaluated cognitive behavioral therapy for insomnia in patients with primary brain tumors …
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CLINICAL_TRIALS trial_result · 2025-09-25Clinical Trial Update: LOC-R01 Study of Lenalidomide and Ibrutinib in Association With Rituximab-Methotrexate Procarbazine Vincristin (R-MPV) [Phase 1, Phase 2]
Phase 1/2 LOC-R01 study evaluates lenalidomide and ibrutinib in combination with Rituximab-Methotrexate-Procarbazine-Vincristine (R-MPV) for…
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CLINICAL_TRIALS trial_result · 2025-09-16Clinical Trial Update: New-diagnosed PCNSL Treated With Methotrexate (MTX) and Orelabrutinib-based Regimen
A completed clinical trial investigating the treatment of newly diagnosed primary central nervous system lymphoma with methotrexate plus an …
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CLINICAL_TRIALS trial_result · 2025-08-22Clinical Trial Update: [18F]-Fludarabine PET/MRI in Primary Central Nervous System Lymphoma [Phase 1]
Phase 1 clinical trial evaluating [18F]-Fludarabine PET/MRI in primary CNS lymphoma has completed.
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Phase I Study Evaluating Tolerability, Safety, Pharmacokinetics, and Efficacy of Combined ONO-4059 and R-MPV Therapy for PCNSL [Phase 1]
Phase I trial evaluating tolerability, safety, pharmacokinetics, and preliminary efficacy of combining ONO-4059 with the R-MPV regimen for p…
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CLINICAL_TRIALS trial_result · 2025-05-08Clinical Trial Update: Zanubrutinib in Combination With Pola-R-CHP and High-dose Methotrexate in Patients With Secondary CNS Lymphoma [Phase 1]
This is a Phase 1 trial update evaluating zanubrutinib in combination with Pola-R-CHP and high-dose methotrexate for secondary central nervo…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas [Phase 1, Phase 2]
Clinical trial update on a Phase I/II study evaluating the safety of autologous CD20 CAR-T cells in relapsed or refractory B-cell non-Hodgki…
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: A Nomogram for Predicting the Diagnosis of Central Malignant Tumors Based on Preoperative Clinical Characteristics and Laboratory Indicators:
A completed clinical trial evaluates a nomogram based on preoperative clinical characteristics and laboratory indicators to predict diagnose…
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CLINICAL_TRIALS trial_result · 2025-02-28Clinical Trial Update: Nivolumab and Ibrutinib in Treating Patients With Relapsed or Refractory Central Nervous System Lymphoma [Phase 2]
Phase 2 clinical trial update evaluating the combination of Nivolumab and Ibrutinib in relapsed or refractory central nervous system lymphom…
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CLINICAL_TRIALS trial_result · 2025-01-30Clinical Trial Update: Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System [Phase 2]
A Phase 2 trial investigating tailored treatment for elderly patients with newly diagnosed primary central nervous system lymphoma has compl…