Postoperative Dental Pain
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy. [EARLY_Phase 1]
An early-phase clinical trial is investigating a preemptive multimodal analgesic strategy to reduce endodontic/postoperative dental pain aft…
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CLINICAL_TRIALS trial_result · 2025-07-24Clinical Trial Update: Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction [Phase 1]
Phase 1 clinical trial update investigating prediction of analgesic response to ibuprofen after third-molar extraction; the study is complet…
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CLINICAL_TRIALS trial_result · 2025-07-16Clinical Trial Update: Effect of Different Apical Actions on Local Inflammatory Mediators and Pain [NA]
A completed clinical trial assessing how different apical actions influence local inflammatory mediators and postoperative dental pain.
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CLINICAL_TRIALS research · 2025-06-08Clinical Trial Update: A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults [NA]
Clinical trial registry entry describing a study of ibuprofen combined with curcumin and licorice root supplementation to manage postoperati…
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CLINICAL_TRIALS trial_result · 2025-03-25Clinical Trial Update: A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo [Phase 3]
Phase 3 results for a fixed-dose naproxen sodium and caffeine tablet in relieving pain after dental surgery were posted, comparing the combo…
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CLINICAL_TRIALS trial_result · 2024-06-03Clinical Trial Update: Efficacy of 300 mg Ibuprofen Prolonged-Release Tablets for the Treatment of Pain After Surgical Removal of Impacted Third Molars [Phase 3]
Phase 3 trial evaluating 300 mg ibuprofen prolonged-release tablets for managing pain after surgical removal of impacted third molars; resul…
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CLINICAL_TRIALS trial_result · 2024-03-01Clinical Trial Update: Efficacy of Trypsin-Chymotrypsin On Post-operative Pain After Single Visit Root Canal Treatment [Phase 4]
A Phase 4 clinical trial evaluated the efficacy of trypsin-chymotrypsin on post-operative pain after single-visit root canal treatment; stud…
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CLINICAL_TRIALS trial_result · 2023-08-07Clinical Trial Update: Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain. [Phase 2]
A Phase 2 clinical trial of MR-107A-02 for post-surgical dental pain has completed with results posted in 2023.
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CLINICAL_TRIALS trial_result · 2022-09-28Clinical Trial Update: Study of Acetaminophen (ACM) in Post-operative Dental Pain [Phase 3]
Phase 3 clinical trial evaluating acetaminophen for postoperative dental pain has completed.
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CLINICAL_TRIALS trial_result · 2021-10-07Clinical Trial Update: Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed [Phase 4]
Phase 4 trial comparing naproxen sodium tablets to hydrocodone/acetaminophen for pain relief after wisdom teeth removal has completed; resul…
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CLINICAL_TRIALS trial_result · 2021-04-15Clinical Trial Update: Randomized, Double-Blind, Single-Dose, Efficacy and Safety Study of Test Acetaminophen Tablet in Postoperative Dental Pain [Phase 3]
Phase 3 randomized trial evaluating efficacy and safety of a single-dose acetaminophen tablet for post-operative dental pain completed.
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CLINICAL_TRIALS trial_result · 2020-12-11Clinical Trial Update: Analgesic Effect of Peripheral Dexmedetomidine [Phase 3]
Phase 3 trial update on the analgesic effect of peripheral dexmedetomidine for pain relief after third molar extraction; results posted.
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CLINICAL_TRIALS trial_result · 2018-06-01Clinical Trial Update: Efficacy Of PF-05089771 In Treating Postoperative Dental Pain [Phase 2]
Pfizer completed a Phase 2 trial evaluating PF-05089771 for postoperative dental pain, with results posted in 2018.
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CLINICAL_TRIALS trial_result · 2017-08-30Clinical Trial Update: A Safety And Efficacy Study of Ibuprofen 250 mg / Acetaminophen 500 mg In The Treatment Of Post-Surgical Dental Pain [Phase 3]
Phase 3 study evaluating the safety and efficacy of a fixed-dose combination of ibuprofen 250 mg and acetaminophen 500 mg for postoperative …
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CLINICAL_TRIALS trial_result · 2016-11-16Clinical Trial Update: Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain [Phase 3]
Phase 3 trial update evaluating the efficacy and safety of ibuprofen combined with caffeine for postoperative dental pain; results have been…
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CLINICAL_TRIALS trial_result · 2016-10-17Clinical Trial Update: A Study to Assess the Efficacy and Tolerability of Diclofenac Potassium Soft Gelatin Capsules Compared With Ibuprofen Tablets in Patients With Moderate to Severe Postoperative Dental Pain [Phase 3]
A Phase 3 trial evaluated the efficacy and tolerability of diclofenac potassium soft gelatin capsules versus ibuprofen tablets in patients w…
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CLINICAL_TRIALS trial_result · 2016-10-12Clinical Trial Update: Phase 3 Study of Tramadol Hydrochloride/Acetaminophen SR Tab. & Tramadol Hydrochloride/Acetaminophen Tab. in Acute Toothache Patients After Teeth Extraction Surgery [Phase 3]
Phase 3 study evaluating tramadol hydrochloride/acetaminophen formulations for acute dental pain after tooth extraction has completed.
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FDA label_change · 2016-09-13FDA Approved: CELECOXIB — Supplemental Application (Cipla USA Inc.)
FDA Approved: CELECOXIB — Supplemental Application (Cipla USA Inc.) indicating a labeling modification related to celecoxib.
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CLINICAL_TRIALS trial_result · 2015-04-29Clinical Trial Update: Post-operative Dental Pain Study Comparing Two Different Dosage of Analgesic Efficacy [Phase 4]
A Phase 4 trial comparing two dosage levels of an analgesic for post-operative dental pain has posted results.
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CLINICAL_TRIALS trial_result · 2015-03-26Clinical Trial Update: Study Testing Ketamine Sublingual Wafer After Wisdom Tooth Extraction [Phase 2]
Phase 2 study evaluating a ketamine sublingual wafer for postoperative dental pain after wisdom tooth extraction has completed.
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CLINICAL_TRIALS trial_result · 2014-07-14Clinical Trial Update: Study to Assess the Kinetic of the Analgesic Effect and Tolerability of Eschscholtzia Californica Versus Ibuprofen and Placebo in the Treatment of Pain After Surgery of the Third Molar [Phase 2]
Phase 2 randomized trial comparing Eschscholtzia Californica extract with ibuprofen and placebo for postoperative dental pain after wisdom t…
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CLINICAL_TRIALS trial_result · 2013-06-28Clinical Trial Update: Efficacy Of Pf-04531083 In Treating Post-Surgical Dental Pain [Phase 2]
Pfizer's Phase 2 trial of Pf-04531083 for postoperative dental pain was terminated, and the results were posted in 2013.
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CLINICAL_TRIALS trial_result · 2010-01-29Clinical Trial Update: A Study to Asses the Effect of MK0663 in the Treatment of Patients With Postoperative Dental Pain (0663-092) [Phase 3]
Phase 3 clinical trial evaluating MK0663 for postoperative dental pain has completed with results posted in 2010.