Pik3ca-related Overgrowth Spectrum

• CLINICAL_TRIALS research · 2026-04-24
  Clinical Trial Update: Study of Proteus Syndrome and Related Congenital Disorders

  Clinical trial update noting that the study examining Proteus syndrome and PIK3CA-related overgrowth spectrum is currently recruiting.

• CLINICAL_TRIALS research · 2026-04-14
  Clinical Trial Update: Managed Access Programs for BYL719, Alpelisib

  Novartis' alpelisib (BYL719) is available through managed access programs for PIK3CA-Related Overgrowth Spectrum and breast cancer.

• CLINICAL_TRIALS research · 2026-04-06
  Clinical Trial Update: EPIK-P4: A Phase II Single-arm Study to Assess the Efficacy, Safety and Pharmacokinetics of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum (PROS) [Phase 2]

  A Phase II single-arm trial (EPIK-P4) is evaluating the efficacy, safety, and pharmacokinetics of alpelisib in pediatric and adult patients …

• CLINICAL_TRIALS research · 2026-01-08
  Clinical Trial Update: A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation [Phase 2]

  Phase 2 clinical trial update for RLY-2608, a mutant-selective PI3Kα inhibitor, in adults and children with PIK3CA-related overgrowth spectr…

• CLINICAL_TRIALS research · 2025-09-24
  Clinical Trial Update: Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of CYH33 in Patients With PIK3CA-related Overgrowth Spectrum (PROS) and PIK3CA-related Vascular Malformations (PRVM) [Phase 1, Phase 2]

  A Phase 1/2 clinical trial is evaluating CYH33 for PIK3CA-related Overgrowth Spectrum (PROS) and PIK3CA-related Vascular Malformations (PRVM…

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• CLINICAL_TRIALS research · 2025-06-24
  Clinical Trial Update: Health-related Quality of Life, Symptom Severity, and Pain Among Patients With PIK3CA-related Overgrowth Spectrum: A Mixed-methods Observational Study

  This completed observational study evaluated health-related quality of life, symptom severity, and pain in patients with PIK3CA-related Over…

• CLINICAL_TRIALS research · 2025-02-07
  Clinical Trial Update: A Study of the Safety and Tolerability in Participants With PIK3CA-related Overgrowth Spectrum or Proteus Syndrome Who Are Being Treated With Miransertib (MK-7075) in Other Studies (MK-7075-006) [Phase 2]

  This is a Phase 2 clinical trial update on the safety and tolerability of miransertib (MK-7075) in participants with PIK3CA-related overgrow…