Persistent Pulmonary Hypertension of the Newborn
📧 Sign up to get email alerts when something new happens for Persistent Pulmonary Hypertension of the Newborn.
Sign up freeTop drugs studied for this disease
-
CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Preductal Oxygen Saturation Target in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure or Pulmonary Hypertension [NA]
This clinical trial update describes a study evaluating preductal oxygen saturation targets in term and late preterm neonates with hypoxemic…
-
CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn
This clinical trial explores PTGS1 genetic variation and its potential link to increased risk of Persistent Pulmonary Hypertension of the Ne…
-
CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial) [Phase 3]
Phase 3 REFSAL trial update on an inhaled β2-adrenergic receptor agonist for Transient Tachypnea of the Newborn; the study is currently acti…
-
CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: Milrinone in Congenital Diaphragmatic Hernia [Phase 2]
A Phase 2 trial evaluating milrinone for congenital diaphragmatic hernia with persistent pulmonary hypertension of the newborn has completed…
-
CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Treprostinil in Newborns With Pulmonary Hypertension; a Non-Interventional Study to Collect Data on Drug Utilization, Safety, and Effectiveness
A non-interventional study to collect data on the utilization, safety, and effectiveness of treprostinil in newborns with persistent pulmona…
- Want full summaries, importance scores, and drug timelines? Upgrade to Plus or Pro.
-
CLINICAL_TRIALS trial_result · 2025-07-29Clinical Trial Update: Melatonin Effects on the Left Ventricular Function in Neonates With Persistent Pulmonary Hypertension [NA]
This clinical trial update reports completion of a study evaluating the effects of melatonin on left ventricular function in neonates with p…
-
CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: The Effect Of Nebulizied Nitroglycerin As An Adjuvant Therapy For Persistent Pulmonary Hypertension Of Newborns [NA]
This completed clinical trial evaluated nebulized nitroglycerin as an adjuvant therapy for persistent pulmonary hypertension of the newborn,…
-
CLINICAL_TRIALS trial_result · 2025-03-06Clinical Trial Update: Vardenafil Vs Sildenafil for the Treatment of Pulmonary Hypertension of the Newborn [Phase 1, Phase 2]
This clinical trial update reports completed Phase 1 and Phase 2 studies comparing vardenafil to sildenafil for treating persistent pulmonar…
-
CLINICAL_TRIALS research · 2025-02-18Clinical Trial Update: Close Loop Smart Weaning for INO With PPHN [NA]
This clinical trial update describes a study on close-loop smart weaning for inhaled nitric oxide in newborns with persistent pulmonary hype…
-
CLINICAL_TRIALS trial_result · 2025-02-05Clinical Trial Update: Treatment of Persistent Pulmonary Hypertension in Neonates With Nebulized Magnesium Sulfate [Phase 2, Phase 3]
A trial update indicates completion of Phase 2 and Phase 3 studies testing nebulized magnesium sulfate for persistent pulmonary hypertension…
-
CLINICAL_TRIALS withdrawal · 2024-12-06Clinical Trial Update: Endovenous Sildenafil Early Management in Newborns Pulmonary Hypertension [NA]
The trial evaluating intravenous sildenafil for early management of persistent pulmonary hypertension in newborns has been withdrawn.
-
CLINICAL_TRIALS trial_result · 2024-11-27Clinical Trial Update: Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating nebulized magnesium sulfate in combination with sildenafil for Persistent Pulmonary Hypertension of th…
-
CLINICAL_TRIALS trial_result · 2024-08-26Clinical Trial Update: Efficacy of Milrinone With Sildenafil in Persistent Pulmonary Hypertension in Children [NA]
Clinical trial update reporting on the efficacy of combining milrinone with sildenafil for persistent pulmonary hypertension of the newborn;…
-
CLINICAL_TRIALS trial_result · 2024-03-05Clinical Trial Update: Remodulin as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn [Phase 2]
Phase 2 trial of Remodulin as add-on therapy for persistent pulmonary hypertension of the newborn has been terminated; results posted.
-
FDA approval · 2023-07-27FDA Approved: ULSPIRA — Original Application (Airgas Therapeutics, LLC)
The FDA approved ULSPIRA (nitric oxide) through an original application (ANDA203144) by Airgas Therapeutics, LLC, establishing it as an inha…
-
CLINICAL_TRIALS trial_result · 2022-05-20Clinical Trial Update: Oral Sildenafil in Persistent Pulmonary Hypertension Secondary to Meconium Aspiration Syndrome in Newborns [Phase 4]
Phase 4 trial update evaluating oral sildenafil for persistent pulmonary hypertension in newborns with meconium aspiration syndrome has comp…
-
CLINICAL_TRIALS trial_result · 2020-08-18Clinical Trial Update: Nebulized MgSO4 in Persistent Pulmonary Hypertension of Newborn [Phase 1, Phase 2]
Phase 1/2 trial evaluating nebulized magnesium sulfate for persistent pulmonary hypertension of the newborn has completed.
-
CLINICAL_TRIALS trial_result · 2020-03-25Clinical Trial Update: A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn [Phase 3]
Phase 3 trial evaluating safety and efficacy of intravenous sildenafil in neonates with persistent pulmonary hypertension; study completed w…
-
CLINICAL_TRIALS trial_result · 2020-03-19Clinical Trial Update: Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN
Completed clinical trial studying inflammatory markers and lung recovery in ECMO-treated newborns with persistent pulmonary hypertension.
-
CLINICAL_TRIALS withdrawal · 2020-01-07Clinical Trial Update: Early iNO for Oxidative Stress, Vascular Tone and Inflammation in Babies With Hypoxic Respiratory Failure [Phase 4]
Clinical trial investigating early inhaled nitric oxide for oxidative stress and inflammation in newborns with respiratory failure was withd…
-
FDA approval · 2019-12-20FDA Approved: GENOSYL — Original Application (VERO BIOTECH, INC.)
FDA approved GENOSYL (nitric oxide) from Vero Biotech, Inc., an inhaled nitric oxide therapy for term and near-term neonates with hypoxic re…
-
FDA approval · 2019-02-13FDA Approved: INOMAX — Supplemental Application (INO Therapeutics LLC)
The FDA approved a supplemental application for INOMAX (nitric oxide) submitted by INO Therapeutics LLC.
-
CLINICAL_TRIALS trial_result · 2019-02-01Clinical Trial Update: Study of Sildenafil to Treat Newborns With Persistent Pulmonary Hypertension [Phase 2]
A Phase 2 study evaluating sildenafil for newborns with persistent pulmonary hypertension was terminated, with results posted.
-
CLINICAL_TRIALS trial_result · 2016-11-02Clinical Trial Update: Pharmacokinetics of Sildenafil in Premature Infants [Phase 1]
Phase 1 pharmacokinetic study of sildenafil in premature infants with persistent pulmonary hypertension of the newborn; the trial has comple…
-
CLINICAL_TRIALS trial_result · 2016-09-07Clinical Trial Update: Plethismographic Perfusion Index in Neonates
Clinical trial update on Plethismographic Perfusion Index in neonates, involving patent ductus arteriosus and persistent pulmonary hypertens…