Periapical Periodontitis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-08-19Clinical Trial Results: Comparison of Clinical Outcomes Between GentleWave® and Biolase® [NA]
Clinical trial comparing outcomes of GentleWave versus Biolase in endodontic disease conditions; results posted after completion.
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment [NA]
A clinical trial update comparing two medicines for healing jaw bone infections after root canal treatment; the study is currently not yet r…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Cryotherapy and Intracanal Medicaments for Postoperative Pain in Apical Periodontitis [Phase 2]
Phase 2 clinical trial evaluating cryotherapy and intracanal medicaments for postoperative pain in periapical periodontitis has completed.
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis [NA]
This clinical trial update reports on a completed study examining the roles of prostaglandin and nitric oxide synthesis in periapical period…
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical Periodontitis [NA]
This completed clinical trial evaluated the effect of EDDY Sonic Irrigation on root canal microbiota and pain in asymptomatic apical periodo…
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars [NA]
This clinical trial evaluated the impact of targeted endodontic microsurgery on quality of life and healing in mandibular molars; the study …
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Single-Visit and Two-Visit Endodontic Treatments [NA]
Completed study assessing single-visit versus two-visit endodontic treatments for endodontic infection and periapical periodontitis, sponsor…
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CLINICAL_TRIALS trial_result · 2025-12-24Clinical Trial Update: Effects of Different Irrigation Activation Techniques on the Healing of Large Periapical Lesions [NA]
A completed clinical trial from Recep Tayyip Erdogan University evaluated different irrigation activation techniques (including lasers) for …
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: PRF and CGF Scaffolds With EDTA in Regeneration [NA]
This entry reports a completed clinical trial evaluating PRF and CGF scaffolds with EDTA for regenerative endodontics in immature permanent …
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing [Phase 2]
Phase 2 clinical trial evaluating different intracanal dressings for improving periapical healing in failed root canal cases has completed.
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CLINICAL_TRIALS trial_result · 2025-08-24Clinical Trial Update: Three Techniques in Bioceramic Apexification for Necrotic Immature Incisors [NA]
Clinical trial completion update on three bioceramic apexification techniques for necrotic immature incisors, sponsored by Damascus Universi…
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: Comparison of Clinical Outcomes Between GentleWave® and Biolase® [NA]
A completed clinical trial evaluating clinical outcomes between the GentleWave dental system and a Biolase device for endodontic and related…
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CLINICAL_TRIALS trial_result · 2025-07-30Clinical Trial Update: Application of Advanced Platelet-Rich Fibrin Plus (A-PRF+) in Revascularisation of Necrotic Immature Permanent Teeth [NA]
A clinical trials update reports the completion of a study evaluating Advanced Platelet-Rich Fibrin Plus (A-PRF+) for revascularization of n…
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CLINICAL_TRIALS trial_result · 2025-07-29Clinical Trial Update: Evaluation of the Efficacy of Growth Hormone, EndoSeal MTA Sealer, and Their Combination on Healing of Periapical Pathosis [NA]
A completed clinical trial evaluated the efficacy of Growth Hormone, EndoSeal MTA Sealer, and their combination for healing periapical patho…
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CLINICAL_TRIALS trial_result · 2025-06-13Clinical Trial Update: Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8 [NA]
A completed clinical trial comparing simvastatin versus calcium hydroxide as intracanal medications for periapical periodontitis, assessing …
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CLINICAL_TRIALS trial_result · 2025-06-05Clinical Trial Update: Efficacy of Apical Preparation With Passive Ultrasonic Irrigation in Reducing Intracanal Bacteria [NA]
Clinical trial evaluating whether passive ultrasonic irrigation improves apical disinfection and reduces intracanal bacteria in teeth with p…
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions [NA]
Completed clinical trial from Recep Tayyip Erdogan University evaluating the impact of irrigation-activation techniques on healing of large …
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CLINICAL_TRIALS trial_result · 2025-04-18Clinical Trial Update: Premixed Bioceramic Putty as an Apical Plug in Immature Anterior Permanent Teeth [NA]
Completed clinical trial evaluating Premixed Bioceramic Putty as an apical plug in immature anterior permanent teeth with periapical periodo…
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CLINICAL_TRIALS trial_result · 2025-04-04Clinical Trial Update: Dexamethasone Treatment for Patients Undergoing Endodontics [Phase 4]
Phase 4 trial update announcing the completion of a dexamethasone treatment study in patients undergoing endodontic therapy for pulp necrosi…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Outcome of Bone Window Approach in Endodontic Microsurgery Using Novel Piezoelectric Device [NA]
This clinical trial update reports on a bone window approach in endodontic microsurgery using a novel piezoelectric device, sponsored by the…
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CLINICAL_TRIALS trial_result · 2024-07-12Clinical Trial Update: Minimally Invasive Root Canal Treatment With Active Disinfection on Single Rooted Teeth With Periapical Lesions [NA]
A completed clinical trial evaluating a minimally invasive root canal treatment with ultrasonic activation of heated sodium hypochlorite, wi…
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CLINICAL_TRIALS trial_result · 2024-05-06Clinical Trial Update: A Comparison Between Two Types of Sealers in the Healing of Periapical Lesions [NA]
This clinical trial compared two types of sealers used in endodontic treatment to heal periapical lesions. The study has completed, and resu…
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CLINICAL_TRIALS trial_result · 2020-10-08Clinical Trial Update: Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections [NA]
Completed clinical trial evaluating adjunctive steps for disinfection in teeth with primary endodontic infections; results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-01-21Clinical Trial Update: Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration. [NA]
A completed clinical trial evaluating encapsulated mesenchymal stem cells for dental pulp regeneration in periapical periodontitis, with res…
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CLINICAL_TRIALS trial_result · 2019-01-17Clinical Trial Update: Magnetic Resonance Imaging (MRI) of Pulp Regeneration [Phase 2]
A Phase 2 clinical trial evaluating MRI imaging for pulp regeneration in teeth with pulp necrosis and periapical lesions has completed.