Partial-onset Seizures
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Dose-Escalation Study of Cenobamate (YKP3089) in Pediatric Subjects With Partial-Onset Seizures [Phase 1]
This clinical trial update describes a Phase 1 dose-escalation study of cenobamate in pediatric patients with partial-onset seizures. The st…
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CLINICAL_TRIALS trial_result · 2024-05-14Clinical Trial Update: Safety and Pharmacokinetic Study of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures [Phase 3]
This update reports the completion of a Phase 3 safety and pharmacokinetic study of cenobamate (YKP3089) as adjunctive therapy for partial o…
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CLINICAL_TRIALS trial_result · 2023-11-09Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Brivaracetam in Study Participants (>=16 to 80 Years of Age) With Epilepsy [Phase 3]
This Phase 3 trial evaluated the efficacy and safety of Brivaracetam in participants with epilepsy, including partial-onset seizures with or…
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CLINICAL_TRIALS trial_result · 2022-05-16Clinical Trial Update: Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With Primary Generalized Tonic-Clonic Seizures [Phase 4]
Phase 4 trial evaluating perampanel as monotherapy or first adjunctive therapy for various seizure types in partial onset and generalized se…
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CLINICAL_TRIALS trial_result · 2022-04-29Clinical Trial Update: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures [Phase 2]
Phase 2 double-blind, randomized, placebo-controlled trial evaluating YKP3089 as adjunctive therapy for partial onset seizures; results were…
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CLINICAL_TRIALS trial_result · 2021-03-05Clinical Trial Update: Phase II BGG492 Capsule Extension for Partial Epilepsy [Phase 2]
Phase II extension trial update for BGG492 capsule in partial epilepsy (partial onset seizures) completed.
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CLINICAL_TRIALS trial_result · 2020-12-17Clinical Trial Update: Efficacy and Safety of BGG492 as Adjunctive Treatment in Patients With Partial Onset Seizures [Phase 2]
Phase 2 trial update on BGG492 as adjunctive treatment for partial onset seizures reports efficacy and safety findings.
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CLINICAL_TRIALS trial_result · 2020-08-13Clinical Trial Update: Study to Evaluate the Safety, Tolerability, and Efficacy of Long-term Adjunctive Therapy With Lacosamide in Adults With Partial-onset Seizures [Phase 3]
Phase 3 trial assessing long-term adjunctive lacosamide in adults with partial-onset seizures; study completed with results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-06-05Clinical Trial Update: A Study With an Open-label Extension Phase to Evaluate the Efficacy and Safety of Perampanel (E2007) Administered as an Adjunctive Therapy in Subjects With Refractory Partial-onset Seizures [Phase 3]
Phase 3 study of perampanel (E2007) as adjunctive therapy in refractory partial-onset seizures completed with posted results.
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CLINICAL_TRIALS trial_result · 2020-04-06Clinical Trial Update: Perampanel as Adjunctive Therapy in Pediatrics With Partial Onset Seizures or Primary Generalized Tonic Clonic Seizures [Phase 3]
Phase 3 trial update for perampanel as adjunctive therapy in pediatric partial onset seizures or primary generalized tonic-clonic seizures; …
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CLINICAL_TRIALS trial_result · 2020-02-25Clinical Trial Update: Study for Verification of Efficacy and Safety for Perampanel Monotherapy in Untreated Participants With Partial Onset Seizures (Including Secondarily Generalized Seizures (FREEDOM Study) [Phase 3]
Phase 3 trial evaluating perampanel monotherapy for partial onset seizures has completed with results posted.
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CLINICAL_TRIALS trial_result · 2019-11-15Clinical Trial Update: Long-term Safety and Tolerability of TRI476 (Oxcarbazepine) in Children With Inadequately Controlled Partial Onset Seizures [Phase 2, Phase 3]
A long-term safety and tolerability update of TRI476 (oxcarbazepine) in children with inadequately controlled partial onset seizures from a …
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CLINICAL_TRIALS trial_result · 2019-06-28Clinical Trial Update: A Trial to Evaluate the Long Term Safety and Tolerability of Lacosamide Taken as Monotherapy in Adults With Partial-onset Seizures [Phase 3]
A Phase 3 long-term safety and tolerability study of lacosamide as monotherapy in adults with partial-onset seizures has completed with resu…
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CLINICAL_TRIALS trial_result · 2018-10-09Clinical Trial Update: A Safety, Efficacy, and Tolerability Trial of Pregabalin as Add-On Treatment in Pediatric Subjects <4 Years of Age With Partial Onset Seizures. [Phase 3]
A Phase 3 trial evaluated pregabalin as add-on therapy in pediatric subjects under 4 with partial onset seizures; results completed with pos…
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CLINICAL_TRIALS trial_result · 2018-02-26Clinical Trial Update: Long-Term Safety Study of Retigabine Immediate Release (IR) as Adjunctive Therapy in the Treatment of Adults With Partial-Onset Seizures (POS) [Phase 3]
Phase 3 long-term safety study of retigabine IR as adjunctive therapy for adults with partial-onset seizures has completed with results post…
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CLINICAL_TRIALS trial_result · 2017-03-09Clinical Trial Update: Study to Investigate Dosage, Efficacy, and Safety of Perampanel Given as Monotherapy in Patients With Epilepsy
This entry notes a completed clinical trial evaluating the dosage, efficacy, and safety of perampanel as monotherapy in patients with epilep…
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CLINICAL_TRIALS trial_result · 2017-01-18Clinical Trial Update: A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures [Phase 3]
A Phase 3 double-blind trial evaluating brivaracetam as monotherapy in adults with partial-onset seizures was terminated, with results poste…
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CLINICAL_TRIALS trial_result · 2016-12-05Clinical Trial Update: Study Evaluating LAMICTAL Extended-Release Therapy Added To Current Seizure Treatments In Patients With Partial Seizures [Phase 3]
A Phase 3 trial evaluating lamotrigine extended-release added to existing seizure therapies in patients with partial-onset seizures has comp…
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CLINICAL_TRIALS trial_result · 2016-09-29Clinical Trial Update: Efficacy and Safety of Eslicarbazepine Acetate as Monotherapy for Patients With Newly Diagnosed Partial-onset Seizures [Phase 3]
Efficacy and safety results from a Phase 3 trial evaluating eslicarbazepine acetate as monotherapy in adults with newly diagnosed partial-on…
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CLINICAL_TRIALS trial_result · 2016-08-11Clinical Trial Update: Open-label, Randomized, Active-controlled Study of LEV Used as Monotherapy in Patients With Partial-Onset Seizures [Phase 3]
A Phase 3 open-label, randomized, active-controlled study evaluating levetiracetam as monotherapy for partial-onset seizures has completed; …
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CLINICAL_TRIALS trial_result · 2016-04-13Clinical Trial Update: A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures [Phase 3]
A Phase 3 double-blind, randomized study evaluating brivaracetam monotherapy for partial-onset seizures in adults was terminated but results…
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CLINICAL_TRIALS trial_result · 2016-02-12Clinical Trial Update: Levetiracetam Versus Topiramate as Adjunctive Therapy to Evaluate Efficacy and Safety in Subjects With Refractory Partial Onset Seizures [Phase 4]
A Phase 4 trial compared adjunctive levetiracetam to topiramate in adults with refractory partial-onset seizures. The study is completed and…
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CLINICAL_TRIALS trial_result · 2016-01-26Clinical Trial Update: Evaluation of the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures [Phase 3]
Phase 3 trial update evaluating adjunctive perampanel (E2007) for refractory partial seizures in epilepsy; results were posted in 2016.
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CLINICAL_TRIALS trial_result · 2015-12-21Clinical Trial Update: Safety & Efficacy of Eslicarbazepine Monotherapy in Sub.w/Partial Epilepsy Not Well Controlled by Current Antiepileptic [Phase 3]
Phase 3 trial evaluating safety and efficacy of eslicarbazepine monotherapy in patients with partial epilepsy not well controlled by current…
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CLINICAL_TRIALS trial_result · 2015-12-04Clinical Trial Update: Open-label Study to Evaluate the Safety and Tolerability of iv Lacosamide in Japanese Adults With Partial-onset Seizures [Phase 3]
An open-label Phase 3 study evaluated the safety and tolerability of intravenous lacosamide in Japanese adults with partial-onset seizures; …