Parkinson Disease with Dementia

• CLINICAL_TRIALS trial_result · 2026-06-12
  Clinical Trial Results: Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Parkinson's Disease [Phase 2]

  Phase 2 clinical trial assessing nilotinib in Parkinson's disease with and without dementia; results completed and posted.

• CLINICAL_TRIALS research · 2026-03-20
  Clinical Trial Update: A Study to Evaluate Temporary Blood Brain Barrier Disruption in Patients With Parkinson's Disease Dementia [NA]

  This clinical trial update notes the completion of a study evaluating temporary blood-brain barrier disruption in patients with Parkinson's …

• CLINICAL_TRIALS trial_result · 2025-11-19
  Clinical Trial Update: Multidisciplinary Study of Novel NMDA Modulation for Neurodegenerative Disorder [Phase 2]

  Phase 2 trial evaluating a novel NMDA modulation approach for Parkinson's disease with dementia has completed.

• CLINICAL_TRIALS research · 2025-09-29
  Clinical Trial Update: OCT-Angiography and Adaptive Optics in Patients With Memory Impairment [NA]

  An ongoing clinical trial is evaluating OCT-Angiography and adaptive optics imaging in memory-impaired patients, including Alzheimer's disea…

• CLINICAL_TRIALS withdrawal · 2025-06-05
  Clinical Trial Update: A Pilot Study to Explore the Role of Gut Flora in Parkinson's Disease

  A pilot study from ProgenaBiome investigating the role of gut flora in Parkinson's disease has been withdrawn.

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• CLINICAL_TRIALS research · 2025-05-28
  Clinical Trial Update: Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients [NA]

  Clinical trial update for deep cervical lymphaticovenous anastomosis surgery in moderate-to-advanced dementia patients; the study is not yet…

• CLINICAL_TRIALS research · 2025-05-18
  Clinical Trial Update: ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing [NA]

  A recruiting clinical trial sponsored by Sunnybrook Health Sciences Centre is evaluating home sleep apnea testing to improve outcomes in cog…

• CLINICAL_TRIALS research · 2025-03-19
  Clinical Trial Update: Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease [NA]

  A clinical trial at University Hospital, Montpellier is recruiting to study neuropsychological profiles and the impact of musical engagement…

• CLINICAL_TRIALS trial_result · 2022-08-01
  Clinical Trial Update: OLE Study for Patients With Parkinson's Disease With Dementia Enrolled in Study ANAVEX2-73-PDD-001 [Phase 2]

  Phase 2 open-label study update for ANAVEX2-73 in Parkinson's disease with dementia has completed.

• CLINICAL_TRIALS trial_result · 2020-10-22
  Clinical Trial Update: ANAVEX2-73 Study in Parkinson's Disease Dementia [Phase 2]

  Phase 2 trial results update for ANAVEX2-73 in Parkinson's disease dementia has completed.

• CLINICAL_TRIALS trial_result · 2019-04-19
  Clinical Trial Update: SYN120 Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE) [Phase 2]

  Phase 2 trial of SYN120 in Parkinson's Disease Dementia has completed; results posted in 2019.

• CLINICAL_TRIALS trial_result · 2019-03-14
  Clinical Trial Update: Impact of Nilotinib on Safety, Tolerability, Pharmacokinetics and Biomarkers in Parkinson's Disease [Phase 2]

  Phase 2 clinical trial update examining nilotinib's safety, tolerability, pharmacokinetics, and biomarkers in Parkinson's disease and Parkin…

• CLINICAL_TRIALS trial_result · 2017-09-25
  Clinical Trial Update: Multi-centre UK Study of the Acetylcholinesterase Inhibitor Donepezil in Early Dementia Associated With Parkinson's Disease [Phase 3]

  A multi-centre UK Phase 3 trial of donepezil in early dementia associated with Parkinson's disease was terminated.

• CLINICAL_TRIALS research · 2015-08-06
  Clinical Trial Update: The Efficacy and Safety Study of High Dose Donepezil in Parkinson's Disease With Dementia [Phase 2]

  This document reports an ongoing Phase 2 trial testing high-dose donepezil for efficacy and safety in Parkinson's disease with dementia.

• CLINICAL_TRIALS trial_result · 2014-09-18
  Clinical Trial Update: Predictive and Diagnostic Value of Tau and Beta-amyloid Markers in the Dementia of Parkinson's Disease [EARLY_Phase 1]

  An early-phase study evaluating whether tau and beta-amyloid biomarkers can predict and diagnose dementia in Parkinson's disease.

• CLINICAL_TRIALS trial_result · 2014-02-26
  Clinical Trial Update: The Effects of the Rivastigmine Patch on Parkinson's Disease With Memory and/or Thinking Problems [Phase 4]

  Phase 4 trial evaluating the rivastigmine transdermal patch in Parkinson's disease patients with dementia or memory/thinking problems. Resul…

• CLINICAL_TRIALS trial_result · 2013-08-22
  Clinical Trial Update: The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease [NA]

  A completed clinical trial evaluated pharmacological and electrical modulation of the NMDA pathway to assess effects on cognitive flexibilit…