Ototoxicity
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CLINICAL_TRIALS trial_result · 2026-07-02Clinical Trial Results: SENS-401 to Prevent the Ototoxicity Induced by Cisplatin in Adult Subjects With a Neoplastic Disease [Phase 2]
Phase 2 trial results for SENS-401 aiming to prevent cisplatin-induced ototoxicity in adults with cancer have been completed with results po…
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CLINICAL_TRIALS trial_result · 2026-06-25Clinical Trial Results: SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity [Phase 2]
Phase 2 trial results for SPI-1005 aimed at prevention and treatment of tobramycin-induced ototoxicity have been completed with results post…
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing
A completed clinical trial evaluated whether medications used to treat COVID-19 and the COVID-19 vaccine affect hearing, including potential…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Comparative Study of the Quality of Life of Patients Suffering From OTOTOXICITY Due to Chemotherapy Based on Platinum Salts Fitted With a Hearing Aid Compared to Those Not Fitted. [NA]
A clinical trial evaluating quality of life in cancer patients with chemotherapy-induced ototoxicity from platinum-based drugs, comparing ou…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy [EARLY_Phase 1]
A Phase 1 trial evaluating sodium thiosulfate to protect against cisplatin-induced ototoxicity during salvage cisplatin therapy is currently…
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EMA approval · 2025-05-23EMA Authorised: Pedmarqsi (sodium thiosulfate) — Norgine B.V.
The European Medicines Agency has authorised Pedmarqsi, a sodium thiosulfate product by Norgine B.V., for use in ear diseases with a focus o…
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CLINICAL_TRIALS trial_result · 2020-03-16Clinical Trial Update: Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy [Phase 2]
Phase 2 trial updating strategies to prevent nephrotoxicity and ototoxicity in osteosarcoma therapy; results posted after completion.
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CLINICAL_TRIALS trial_result · 2017-09-25Clinical Trial Update: SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss [Phase 2]
Phase 2 clinical trial update for SPI-1005 addressing prevention and treatment of chemotherapy-induced hearing loss, with related conditions…
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CLINICAL_TRIALS trial_result · 2017-06-01Clinical Trial Update: Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy [Phase 3]
Phase 3 trial evaluating sodium thiosulfate to prevent cisplatin-induced hearing loss in young patients with various pediatric cancers; stud…
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CLINICAL_TRIALS research · 2011-01-28Clinical Trial Update: Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Systemic Treatment With Cisplatin. [NA]
This clinical trial update concerns the use of intratympanic steroid therapy to prevent inner ear toxicity associated with systemic cisplati…
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CLINICAL_TRIALS research · 2010-10-07Clinical Trial Update: Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors [Phase 3]
A Phase 3 trial comparing intensity-modulated radiation therapy (IMRT) with 3-D conformal radiation therapy to reduce hearing loss after sur…
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CLINICAL_TRIALS trial_result · 2010-06-08Clinical Trial Update: The Protective Effect of Ginkgo Biloba Extract on Cisplatin-induced Ototoxicity in Humans [Phase 2]
A Phase 2 clinical trial evaluating whether Ginkgo Biloba Extract protects against cisplatin-induced ototoxicity in humans has completed.
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CLINICAL_TRIALS research · 2007-12-21Clinical Trial Update: Does Aspirin Have a Protective Role Against Chemotherapeutically Induced Ototoxicity? [NA]
A clinical trial is exploring whether aspirin could protect against hearing loss caused by chemotherapy (chemotherapy-induced ototoxicity).