Osteogenesis Imperfecta
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Evaluation and Treatment of Patients With Connective Tissue Disease
This clinical trial update reports on the evaluation and treatment of patients with connective tissue disorders, including osteogenesis impe…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Pediatric Safety Follow-up Study of Prior Treatment With Romosozumab for Osteogenesis Imperfecta [Phase 3]
Phase 3 pediatric safety follow-up study evaluating prior romosozumab treatment in Osteogenesis Imperfecta is currently recruiting. The spon…
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Evaluation and Intervention for the Effects of Osteogenesis Imperfecta
A NICHD-sponsored clinical trial evaluating interventions for the effects of osteogenesis imperfecta has completed.
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Osteogenesis Imperfecta Trial of AGA2115 for ADUlts With COL1A1 and/or COL1A2 GeNetic Variations (IDUN) [Phase 2]
Phase 2 clinical trial update for AGA2115 in adults with Osteogenesis Imperfecta carrying COL1A1/COL1A2 variations; the study is currently r…
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta [Phase 3]
A Phase 3 clinical trial evaluating the efficacy and safety of romosozumab compared with bisphosphonates in children and adolescents with os…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Setrusumab in Pediatric Japanese Subjects With Osteogenesis Imperfecta [Phase 3]
A Phase 3 clinical trial of setrusumab in pediatric Japanese patients with Osteogenesis Imperfecta is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Setrusumab vs Placebo for Osteogenesis Imperfecta [Phase 2, Phase 3]
Clinical trial update indicates a Phase 2/Phase 3 study of Setrusumab versus Placebo for Osteogenesis Imperfecta is currently not recruiting…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta [Phase 3]
Phase 3 clinical trial comparing setrusumab to bisphosphonates in pediatric Osteogenesis Imperfecta; currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2026-02-23Clinical Trial Update: Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and Genotype Phenotype Correlation
This completed clinical trial documents the natural history of Osteogenesis Imperfecta and investigates genotype-phenotype correlations. The…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD) [NA]
A clinical trial update for REMS25 evaluating REMS technology in diseases commonly associated with reduced bone mineral density; recruitment…
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Dental Malocclusion and Craniofacial Development in OI
This Clinical Trials update reports on a study examining dental malocclusion and craniofacial development in osteogenesis imperfecta. The st…
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CLINICAL_TRIALS trial_result · 2026-01-26Clinical Trial Update: Post-market Observational Study on JTIN Telescopic Nail in Osteogenesis Imperfecta Pediatric Patients
A post-market observational study of the JTIN Telescopic Nail in pediatric patients with Osteogenesis Imperfecta has completed and results h…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta
Prospective observational cohort study assessing cardiac structure and function in children and adults with Osteogenesis Imperfecta; current…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Effects of Bisphosphonates on OI-Related Hearing Loss [Phase 4]
Phase 4 clinical trial is evaluating the effects of bisphosphonates on hearing loss associated with Osteogenesis Imperfecta and is currently…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Clear Aligners for the Treatment of Dental Malocclusion in OI [NA]
Clinical trial update indicates a study evaluating clear aligners to treat dental malocclusion in Osteogenesis Imperfecta; the trial is curr…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Urinary Biomarkers of OI Pathobiology
An ongoing Baylor College of Medicine study investigating urinary biomarkers related to osteogenesis imperfecta is currently active but not …
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Registry of Osteogenesis Imperfecta
This clinical trial registry entry covers an ongoing study of Osteogenesis Imperfecta led by Luca Sangiorgi. The study is currently recruiti…
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CLINICAL_TRIALS research · 2025-10-29Clinical Trial Update: Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI) [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial evaluating mesenchymal cell therapy for Osteogenesis Imperfecta (including Type III) is not yet recruiting.…
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CLINICAL_TRIALS trial_result · 2025-09-17Clinical Trial Update: Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic Acid [Phase 4]
A Phase 4 trial evaluating parathyroid hormone and zoledronic acid for osteogenesis imperfecta has completed.
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CLINICAL_TRIALS other · 2025-09-15Clinical Trial Update: Pediatric Arthropathy Beyond Inflammation: Clinical Spectrum and Diagnostic Approach at Assiut University Children Hospital
ClinicalTrials.gov study from Assiut University Children Hospital investigates pediatric arthropathy beyond inflammation and its diagnostic …
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Boost Brittle Bones Before Birth [Phase 1, Phase 2]
Clinical trial update for a Phase 1/2 study in Osteogenesis Imperfecta to boost fetal bone development. The trial is currently active but no…
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Audio-vestibular Evaluation of Children and Young Adults With Osteogenesis Imperfecta
A clinical trial is recruiting to evaluate audio-vestibular function in children and young adults with Osteogenesis Imperfecta.
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CLINICAL_TRIALS trial_result · 2025-09-11Clinical Trial Update: Single Ascending Dose Study of SAR439459 in Adults With Osteogenesis Imperfecta (OI) [Phase 1]
A Phase 1 single ascending dose study of SAR439459 in adults with Osteogenesis Imperfecta has been terminated.
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CLINICAL_TRIALS trial_result · 2025-09-10Clinical Trial Update: Evaluation of the Benefits of Adaptive Physical Activity in Children and Adolescents With Osteogenesis Imperfecta [NA]
A completed clinical trial evaluating the benefits of adaptive physical activity for children and adolescents with osteogenesis imperfecta.
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CLINICAL_TRIALS trial_result · 2025-09-04Clinical Trial Update: Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI Study [NA]
The miROI study investigating epigenetic regulation of Osteogenesis Imperfecta severity has completed.