Oropharyngeal Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-12-16Clinical Trial Update: Activity and Safety of Peptide-based Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck. [Phase 2]
A Phase 2 clinical trial evaluating a peptide-based immunotherapy for head and neck squamous cell carcinoma was terminated; the update repor…
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer [Phase 2]
A Phase 2 trial evaluating Vidutolimod in combination with cemiplimab for adults with advanced or metastatic cancers was terminated, with re…
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma [Phase 1]
Phase 1 study evaluating IRX-2 regimen with durvalumab for incurable head and neck squamous cell carcinoma has completed, including multiple…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Personalized Elective Neck Irradiation Guided by Sentinel Lymph Node Biopsy in Larynx and Pharynx Cancer. The PRIMO Study. [Phase 3]
Phase 3 PRIMO study investigating personalized elective neck irradiation guided by sentinel lymph node biopsy for laryngeal and pharyngeal c…
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Study Comparing Fibula Free-flap MR With or Without PVP in Patients With OOPC [NA]
A completed clinical trial comparing fibula free-flap microreconstruction with or without PVP in patients with oropharyngeal or oral cavity …
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma [Phase 2]
This document provides a Phase 2 trial update on a personalized volume-deescalated elective nodal irradiation approach for oropharyngeal squ…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples?
This clinical trial update describes research into whether recurrence of oropharyngeal cancer can be detected using blood-based tests.
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors [Phase 1]
Phase 1 basket trial evaluating customized autologous TCR-T cell therapies across multiple locally advanced or metastatic solid tumors, spon…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL) [Phase 2]
Phase 2 clinical trial evaluating adjuvant therapy tailored by residual circulating tumor DNA in patients with HPV-positive oropharyngeal sq…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA [Phase 2]
This Phase 2 Mayo Clinic trial evaluates de-escalated adjuvant and definitive radiation therapy for HPV-related oropharyngeal cancer guided …
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer [EARLY_Phase 1]
This early-phase 1 clinical trial compares an investigational F-18 NaF PET/CT imaging approach to standard F-18 FDG PET/CT for evaluating va…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: Pre-Op MRI on Margin Status for Transoral Robotic Surgery for HPV+ Tonsillar Squamous Cell Carcinoma [NA]
This clinical trial update describes using pre-operative MRI to assess margin status during transoral robotic surgery for HPV-positive tonsi…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Phase II Trial of Immunotherapeutic HPV Vaccine PRGN-2009 With Pembrolizumab Before Standard Treatment in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal Cancer [Phase 2]
This phase II study tests adding the HPV vaccine PRGN-2009 with pembrolizumab before standard treatment in newly diagnosed HPV-associated or…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Compartmentalized Postoperative Radiotherapy in Head and Neck Cancer [Phase 2]
A Phase 2 clinical trial evaluating compartmentalized postoperative radiotherapy in head and neck cancer, currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial [NA]
This update describes an ongoing multicenter randomized controlled trial evaluating surgeon-performed ultrasound for real-time guidance duri…
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CLINICAL_TRIALS trial_result · 2025-10-01Clinical Trial Update: Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC [Phase 2]
A Phase 2 trial evaluating the combination of PDS0101 and pembrolizumab in HPV16-positive recurrent/metastatic head and neck cancer has comp…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma [Phase 2]
Phase 2 trial results discuss de-escalation radiotherapy in patients with low-risk HPV-related oropharyngeal squamous cell carcinoma.
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: SURVEILLE-HPV: Evaluation of HPV16 Circulating DNA as Biomarker to Detect the Recurrence, in Order to Improve Post Therapeutic Surveillance of HPV16-driven Oropharyngeal Cancers [Phase 2]
Phase 2 clinical trial investigating HPV16 circulating DNA as a biomarker for detecting recurrence and improving post-therapy surveillance i…
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CLINICAL_TRIALS trial_result · 2025-09-09Clinical Trial Update: Real-world Study of First Line Pembrolizumab- or Nivolumab-treated HPV-positive Recurrent/Metastatic Oropharyngeal Squamous Cell Carcinoma
Completed real-world study evaluating first-line pembrolizumab or nivolumab in HPV-positive recurrent/metastatic oropharyngeal squamous cell…
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CLINICAL_TRIALS research · 2025-08-21Clinical Trial Update: A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC
Observational bidirectional study of NAIC to examine tumor regression patterns in locally advanced oral squamous cell carcinoma and locally …
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CLINICAL_TRIALS withdrawal · 2025-08-15Clinical Trial Update: Phase II Study of Atezolizumab and Tiragolumab With ctDNA for HPV-positive SCC [Phase 2]
Phase II study of atezolizumab and tiragolumab with ctDNA for HPV-positive oropharyngeal squamous cell carcinoma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2025-08-08Clinical Trial Update: Cisplatin or ImmunoTHerapy in Association With Definitive Radiotherapy in HPV-related oropharyngEal Squamous Cell Carcinoma: a Randomized Phase II Trial. [Phase 2]
A randomized Phase II trial comparing cisplatin-based radiotherapy to immunotherapy-based radiotherapy for HPV-related oropharyngeal squamou…
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CLINICAL_TRIALS withdrawal · 2025-07-31Clinical Trial Update: Saliva Testing for High-Risk Human Papillomavirus Infection Oral Cavity and Pharynx Cancer
A clinical trial evaluating saliva testing for high-risk human papillomavirus infection in oral cavity and oropharyngeal cancers has been wi…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110) [Phase 2]
Phase 2 clinical trial evaluating selective avoidance of nodal volumes in head and neck/oropharyngeal cancer; currently active but not recru…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Neoadjuvant and Adjuvant Sintilimab Plus Cetuximab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating neoadjuvant and adjuvant sintilimab plus cetuximab in resectable locally advanced oral and oropharyngeal s…