Oropharyngeal Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers [Phase 1, Phase 2]
An early-phase clinical trial is evaluating TheraT Vectors vaccines in combination with chemotherapy for HPV16-associated head and neck canc…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical study evaluating risk-adapted de-intensification of radiochemotherapy for oropharyngeal squamous cell carcinoma; the trial …
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer [Phase 3]
A Phase 3 clinical trial comparing personalized radiation therapy with standard radiation therapy for HPV-positive oropharyngeal squamous ce…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN) [Phase 2]
A Phase 2 trial assesses neoadjuvant chemotherapy combined with a PD-1 inhibitor for head and neck squamous cell carcinoma with the goal of …
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation [NA]
A clinical trial update describes remote audiometry being studied to monitor treatment-related hearing loss in patients with head and neck s…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Oropharynx (OPX) Biomarker Trial
Mayo Clinic is conducting a biomarker-focused clinical trial in patients with HPV-positive and HPV-negative oropharyngeal cancer across stag…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Neoadjuvant Becotatug Vedotin Plus Pucotenlimab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma (OSCC) [Phase 2]
Phase 2 neoadjuvant trial evaluating Becotatug Vedotin plus Pucotenlimab in locally advanced oral and oropharyngeal squamous cell carcinoma;…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating pembrolizumab given alone versus the standard chemotherapy with radiation after surgery for recurrent head…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer [Phase 2, Phase 3]
A Phase 2/3 clinical trial update evaluating either docetaxel plus cetuximab or adding atezolizumab to standard chemotherapy and radiation f…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer [Phase 1]
A Phase 1 clinical trial is evaluating the addition of the AKT inhibitor ipatasertib to standard chemotherapy and radiation for locally adva…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer [Phase 2]
Phase 2 trial evaluating cemiplimab plus CDX-1140 given before surgery to determine if the combination improves outcomes versus cemiplimab a…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: The Minimalist Trial-2 [Phase 2]
This document reports a Phase 2 clinical trial called Minimalist Trial-2 by Washington University School of Medicine, currently recruiting f…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck [Phase 2]
A Phase 2 clinical trial is exploring adding ipatasertib to pembrolizumab in patients with recurrent or metastatic head and neck squamous ce…
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CLINICAL_TRIALS trial_result · 2026-04-07Clinical Trial Update: Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION) [Phase 2]
Update on a Phase 2 trial (OPERATION) investigating the omission of postoperative radiation in HPV-associated oropharyngeal squamous cell ca…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Risk-adapted Therapy in HPV-positive Oropharyngeal Cancer Using Circulating Tumor (ct) HPV DNA Profiling (ReACT 2.0) [Phase 2]
This Clinical Trials update outlines a Phase 2 study (ReACT 2.0) evaluating risk-adapted therapy guided by circulating tumor HPV DNA profili…
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CLINICAL_TRIALS other · 2026-04-03Clinical Trial Update: Comparing Cisplatin Every Three Weeks to Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck Cancer [Phase 2, Phase 3]
NRG Oncology reports suspension of a phase 2/3 trial comparing cisplatin dosing every three weeks versus weekly when given with radiation fo…
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CLINICAL_TRIALS trial_result · 2026-04-01Clinical Trial Update: Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer [Phase 2]
This Phase 2 trial explores biomarker-guided reduction of radiation therapy dose following transoral robotic surgery for HPV-positive oropha…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Reduced Elective Nodal and CTV Dose for HPV+ Oropharyngeal Squamous Cell Carcinoma [Phase 2]
A Phase 2 clinical trial update proposes reducing elective nodal and clinical target volume doses for HPV-positive oropharyngeal squamous ce…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients [Phase 2]
Phase 2 trial evaluating first-line weekly chemotherapy combined with immunotherapy for metastatic head and neck squamous cell carcinoma; th…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC [Phase 2]
Phase 2 trial evaluating three regimens for intermediate-risk HPV-positive oropharyngeal squamous cell carcinoma: cisplatin with radiotherap…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer [NA]
Clinical trial update describes a SPECT-CT guided elective contralateral neck treatment approach for lateralized oropharyngeal cancer; spons…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery [Phase 2]
A Phase 2 clinical trial is assessing the addition of cisplatin to postoperative radiation therapy for stage III-IV squamous cell carcinoma …
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating the combination of ipilimumab, nivolumab, and radiation therapy in patients with HPV-positive advanced oro…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: The Role of Circulating Tumour DNA in Head and Neck Cancer
A clinical trial from the University of Edinburgh is investigating circulating tumour DNA as a biomarker in oropharyngeal squamous cell carc…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma [NA]
A clinical trial is evaluating de-intensified postoperative radiation therapy for HPV-associated oropharyngeal squamous cell carcinoma, spon…