Oropharyngeal Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED) [Phase 2]
A single-arm Phase II trial (SAVED) in p16-positive oropharyngeal cancer evaluating selective dose de-escalation of nodal and primary-site r…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Tumor Mutational Burden, Liquid Biopsy, Angiogenic Factors and DCE-MRI Perfusion in HPV-Negative Oropharyngeal Cancer [NA]
An ongoing biomarker-focused study evaluating tumor mutational burden, liquid biopsy, angiogenic factors, and DCE-MRI perfusion in HPV-negat…
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: Surgery With or Without Neoadjuvant Treatment of SBRT Plus Chemoimmunotherapy in Resectable Locally Advanced Oral and HPV-unrelated Oropharyngeal Squamous Cell Carcinoma [Phase 3]
A Phase 3 trial evaluating whether adding neoadjuvant SBRT plus chemoimmunotherapy before surgery improves outcomes in resectable locally ad…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck [Phase 2]
This document provides an update on a Phase 2 clinical trial evaluating cemiplimab in combination with low-dose paclitaxel and carboplatin f…
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma [Phase 2]
A Phase 2 clinical trial update evaluating three dosing schedules of CUE-101 given before surgery or definitive chemoradiation in patients w…
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer [Phase 1, Phase 2]
This entry reports a Phase 1/2 clinical trial evaluating Lenti-HPV-07 immunotherapy for HPV-associated cervical cancer and HPV-positive orop…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: The Registry Study of Genetic Alterations of Oropharyngeal Cancer in Taiwan
A registry study conducted by the National Health Research Institutes in Taiwan to catalog genetic alterations in oropharyngeal squamous cel…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Dual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and Oropharynx
A clinical trial is evaluating dual-energy CT versus MRI for staging or evaluating squamous cell carcinomas of the oral cavity and oropharyn…
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma [NA]
A clinical trial update on quality of life comparing primary transoral robotic surgery (TORS) to IMRT for early-stage oropharyngeal squamous…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Personalized Elective Neck Irradiation Guided by Sentinel Lymph Node Biopsy in Larynx and Pharynx Cancer. The PRIMO Study. [Phase 3]
Phase 3 PRIMO study investigating personalized elective neck irradiation guided by sentinel lymph node biopsy for laryngeal and pharyngeal c…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma [Phase 2]
This document provides a Phase 2 trial update on a personalized volume-deescalated elective nodal irradiation approach for oropharyngeal squ…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples?
This clinical trial update describes research into whether recurrence of oropharyngeal cancer can be detected using blood-based tests.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL) [Phase 2]
Phase 2 clinical trial evaluating adjuvant therapy tailored by residual circulating tumor DNA in patients with HPV-positive oropharyngeal sq…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA [Phase 2]
This Phase 2 Mayo Clinic trial evaluates de-escalated adjuvant and definitive radiation therapy for HPV-related oropharyngeal cancer guided …
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer [EARLY_Phase 1]
This early-phase 1 clinical trial compares an investigational F-18 NaF PET/CT imaging approach to standard F-18 FDG PET/CT for evaluating va…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: Pre-Op MRI on Margin Status for Transoral Robotic Surgery for HPV+ Tonsillar Squamous Cell Carcinoma [NA]
This clinical trial update describes using pre-operative MRI to assess margin status during transoral robotic surgery for HPV-positive tonsi…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Phase II Trial of Immunotherapeutic HPV Vaccine PRGN-2009 With Pembrolizumab Before Standard Treatment in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal Cancer [Phase 2]
This phase II study tests adding the HPV vaccine PRGN-2009 with pembrolizumab before standard treatment in newly diagnosed HPV-associated or…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Compartmentalized Postoperative Radiotherapy in Head and Neck Cancer [Phase 2]
A Phase 2 clinical trial evaluating compartmentalized postoperative radiotherapy in head and neck cancer, currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial [NA]
This update describes an ongoing multicenter randomized controlled trial evaluating surgeon-performed ultrasound for real-time guidance duri…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: SURVEILLE-HPV: Evaluation of HPV16 Circulating DNA as Biomarker to Detect the Recurrence, in Order to Improve Post Therapeutic Surveillance of HPV16-driven Oropharyngeal Cancers [Phase 2]
Phase 2 clinical trial investigating HPV16 circulating DNA as a biomarker for detecting recurrence and improving post-therapy surveillance i…
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CLINICAL_TRIALS research · 2025-08-21Clinical Trial Update: A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC
Observational bidirectional study of NAIC to examine tumor regression patterns in locally advanced oral squamous cell carcinoma and locally …
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110) [Phase 2]
Phase 2 clinical trial evaluating selective avoidance of nodal volumes in head and neck/oropharyngeal cancer; currently active but not recru…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Neoadjuvant and Adjuvant Sintilimab Plus Cetuximab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating neoadjuvant and adjuvant sintilimab plus cetuximab in resectable locally advanced oral and oropharyngeal s…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Training Swallowing Initiation During Expiration [NA]
A recruiting clinical trial from Northwestern University studies training swallowing initiation during expiration for head and neck cancer p…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Identification of Individual Histological and Blood Markers in Patients With Recurrent or Metastatic Upper Aerodigestive Tract Squamous Cell Carcinoma in Response to Immunotherapies [NA]
A sponsor-initiated clinical trial is recruiting to identify histological and blood biomarkers in patients with recurrent or metastatic uppe…