Opioid-induced Hyperalgesia
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Investigation of the Strategy of Preventing Post-operative Opioid-induced Hyperalgesia [Phase 4]
Phase 4 clinical trial investigating strategies to prevent postoperative opioid-induced hyperalgesia has completed. The update notes the stu…
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia [Phase 2]
A Phase 2 clinical trial evaluating whether ultra-low dose naloxone can mitigate remifentanil-induced hyperalgesia was terminated.
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CLINICAL_TRIALS trial_result · 2023-10-02Clinical Trial Update: Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone [NA]
This completed clinical trial evaluated perioperative opioid-induced hyperalgesia and whether prophylaxis with ketamine and methadone could …
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CLINICAL_TRIALS trial_result · 2018-06-15Clinical Trial Update: Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids [Phase 2]
Phase 2 trial evaluating whether a beta blocker can mitigate opioid-induced hyperalgesia in humans; results posted.
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CLINICAL_TRIALS trial_result · 2018-03-21Clinical Trial Update: The Effects of Opioid Taper on Opioid-Induced Hyperalgesia
A terminated Georgetown University clinical trial examined how tapering opioids affects opioid-induced hyperalgesia in people with pain, wit…
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CLINICAL_TRIALS trial_result · 2017-01-16Clinical Trial Update: Effect of Ketamine on Opioid-Induced Hyperalgesia [NA]
Clinical trial update on the effects of ketamine for opioid-induced hyperalgesia. The study has completed and results were posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-01-12Clinical Trial Update: Dextromethorphan, Gabapentin, and Oxycodone to Treat Opioid-Induced Hyperalgesia [NA]
A completed clinical trial evaluating a combination of dextromethorphan, gabapentin, and oxycodone for opioid-induced hyperalgesia.
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CLINICAL_TRIALS trial_result · 2017-01-11Clinical Trial Update: Hyperalgesia in Methadone Patients: Can it be Treated? [Phase 1]
A Phase 1 study investigates treating opioid-induced hyperalgesia in methadone-maintained patients. The update does not provide results or c…
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CLINICAL_TRIALS trial_result · 2016-11-16Clinical Trial Update: The Effect of Ultra-low-dose Naloxone on Remifentanil-induced Postoperative Hyperalgesia - A Randomized Controlled Study [NA]
This completed randomized controlled trial evaluated whether ultra-low-dose naloxone can reduce remifentanil-induced postoperative hyperalge…
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CLINICAL_TRIALS trial_result · 2016-10-27Clinical Trial Update: Opioid Induced Hyperalgesia (OIH) Modulation With Propranolol [Phase 4]
Phase 4 clinical trial investigating propranolol to modulate opioid-induced hyperalgesia.
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CLINICAL_TRIALS trial_result · 2014-02-19Clinical Trial Update: Effect of Nefopam on Remifentanil Induced Postoperative Hyperalgesia [NA]
This trial update reports completion of a study evaluating nefopam for preventing remifentanil-induced postoperative hyperalgesia in patient…
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CLINICAL_TRIALS trial_result · 2012-04-30Clinical Trial Update: Opiate-Induced Tolerance & Hyperalgesia in Pain Patients [Phase 4]
Phase 4 clinical trial update on opioid-induced tolerance and hyperalgesia in chronic pain patients. The study status is completed.
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CLINICAL_TRIALS trial_result · 2012-04-06Clinical Trial Update: Hyperalgesia in Methadone-Maintained Patients: Can it be Treated? [Phase 2]
This Phase 2 clinical trial evaluated potential treatments for opioid-induced hyperalgesia in methadone-maintained patients; results have be…