Opioid Dependence
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Sign up freeTop drugs studied for this disease
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FDA approval · 2021-03-04FDA Approved: SUBOXONE — Supplemental Application (INDIVIOR INC.)
The FDA issued approval of a supplemental application for Suboxone (buprenorphine hydrochloride and naloxone hydrochloride) by Indivior Inc.…
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FDA approval · 2021-03-04FDA Approved: ZUBSOLV — Supplemental Application (Orexo US, Inc.)
FDA approved a supplemental application for ZUBSOLV (buprenorphine/naloxone) from Orexo US, Inc. The approval covers changes to labeling and…
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FDA approval · 2021-03-04FDA Approved: BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE DIHYDRATE — Supplemental Application (SpecGx LLC)
FDA approved a supplemental application for a generic buprenorphine hydrochloride and naloxone hydrochloride dihydrate product from SpecGx L…
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CLINICAL_TRIALS trial_result · 2021-02-04Clinical Trial Update: Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal [Phase 3]
Phase 3 trial update evaluating efficacy, safety, and dose-response of lofexidine for opioid withdrawal, followed by an open-label study, wi…
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CLINICAL_TRIALS trial_result · 2020-11-19Clinical Trial Update: Disulfiram for Cocaine Abuse in Buprenorphine Treatment [Phase 2]
Phase 2 clinical trial investigating disulfiram for cocaine dependence in individuals receiving buprenorphine for opioid dependence has comp…
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CLINICAL_TRIALS trial_result · 2020-11-12Clinical Trial Update: Drug Interaction and Subjective Effects of Compounds for Opioid Use Disorder [Phase 1]
Phase 1 clinical trial assessing drug interaction and subjective effects of compounds for opioid use disorder; completed with results posted…
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CLINICAL_TRIALS trial_result · 2020-11-06Clinical Trial Update: Opioid Relapse & HIV Risk: 48 Versus 24 Weeks of Injectable Extended Release Naltrexone [Phase 2, Phase 3]
A clinical trial comparing 48 weeks versus 24 weeks of injectable extended-release naltrexone for opioid dependence with HIV risk, completed…
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CLINICAL_TRIALS trial_result · 2020-10-23Clinical Trial Update: Desvenlafaxine in Opioid-Dependent Patients [Phase 4]
Phase 4 trial update involving desvenlafaxine in patients with depression and opioid dependence (including methadone treatment) has complete…
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CLINICAL_TRIALS trial_result · 2020-10-19Clinical Trial Update: Healthy Adult Male Facial Skin Surface Lipid Pheromone p.o. to Treat Opioid Addiction [Phase 3]
Phase 3 trial update for an oral facial skin lipid pheromone intended to treat opioid addiction appears to be in early or unknown status.
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CLINICAL_TRIALS withdrawal · 2020-10-08Clinical Trial Update: An Open-Label, Single-Center Study to Evaluate the Exposure-Response Relationship Between the Plasma Drug Concentrations and the Change From Baseline in QTc at Steady State Following Once-daily Administration of CASSIPA® in Opioid Dependent Subjects. [Phase 4]
An open-label Phase 4 trial evaluating exposure–response for QTc changes with once-daily CASSIPA in opioid-dependent subjects was withdrawn.
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CLINICAL_TRIALS trial_result · 2020-09-01Clinical Trial Update: Clinical Trial of Integrated Treatment for Pain and Opioid Dependence [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating an integrated treatment for pain and opioid dependence has completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-04-02Clinical Trial Update: Brief Introductory Therapy for Opioid Dependence [Phase 2]
Phase 2 trial update for Brief Introductory Therapy in opioid dependence with HIV coinfection completed.
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CLINICAL_TRIALS trial_result · 2020-03-23Clinical Trial Update: Comparing Interventions for Opioid Dependent Patients Presenting in Medical Emergency Departments [NA]
A completed clinical trial comparing interventions for opioid dependent patients presenting to emergency departments; results posted in 2020…
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CLINICAL_TRIALS trial_result · 2020-03-11Clinical Trial Update: Buprenorphine/Naloxone Stabilization and Induction Onto Injection Naltrexone [Phase 2, Phase 3]
A Phase 2/Phase 3 trial investigating stabilization with buprenorphine/naloxone and induction onto injection naltrexone for opioid dependenc…
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CLINICAL_TRIALS trial_result · 2020-03-05Clinical Trial Update: Community Studies of Long Acting Buprenorphine (CoLAB) [Phase 3]
Phase 3 clinical trial update for Community Studies of Long Acting Buprenorphine (CoLAB) investigating opioid dependence treatment.
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FDA approval · 2019-10-09FDA Approved: METHADONE HYDROCHLORIDE — Supplemental Application (Hikma Pharmaceuticals USA Inc.)
FDA approved a supplemental application for METHADONE HYDROCHLORIDE by Hikma Pharmaceuticals USA Inc., granting approval for a supplemental …
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FDA label_change · 2019-10-07FDA Approved: DISKETS — Supplemental Application (Hikma Pharmaceuticals USA Inc.)
FDA approved a supplemental application for DISKETS (methadone hydrochloride) by Hikma Pharmaceuticals USA Inc., indicating a change to the …
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FDA approval · 2019-09-06FDA Approved: VIVITROL — Supplemental Application (Alkermes, Inc.)
FDA approved a supplemental application for VIVITROL (naltrexone) from Alkermes, Inc., resulting in an updated/expanded approval.
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CLINICAL_TRIALS trial_result · 2019-08-07Clinical Trial Update: Oxytocin Treatment of Opioid Dependence [Phase 1, Phase 2]
Phase 1/2 clinical trial update on oxytocin treatment for opioid dependence and withdrawal.
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CLINICAL_TRIALS trial_result · 2019-07-12Clinical Trial Update: Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use Disorder [Phase 3]
A Phase 3 trial comparing Opium Tincture with Methadone for medication-assisted treatment in opioid dependence has completed.
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EMA approval · 2019-04-26New long-lasting implant to treat opioid dependence
The EMA reports a new long-acting implant for the treatment of opioid dependence, expanding available options for managing opioid use disord…
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CLINICAL_TRIALS trial_result · 2019-03-26Clinical Trial Update: Dane County Drug Court Study for Addicted Offenders [Phase 3]
Phase 3 clinical trial on a Dane County Drug Court program for adults with opioid dependence has completed enrollment; results posted in 201…
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CLINICAL_TRIALS trial_result · 2019-01-09Clinical Trial Update: The Effects of Minocycline in Opioid-maintained Patients [NA]
Clinical trial evaluating the effects of minocycline in opioid-maintained patients has completed with results posted.
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CLINICAL_TRIALS research · 2019-01-07Clinical Trial Update: 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence [NA]
A completed clinical trial investigating 5HT3 antagonists for treating opioid withdrawal and preventing progression of physical dependence.
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CLINICAL_TRIALS trial_result · 2018-12-31Clinical Trial Update: A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addiction [Phase 3]
A six-month Phase 3 randomized controlled trial evaluating Probuphine for opioid dependency has completed.