Non-small Cell Lung Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations [Phase 3]
Phase III open-label first-line study evaluating Dato-DXd in combination with durvalumab and carboplatin for advanced non-small cell lung ca…
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: A Phase 1/2 Study of Anvumetostat in Combination With IDE397 in Participants With Advanced Methylthioadenosine Phosphorylase (MTAP)-Null Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 study evaluating the combination of Anvumetostat with IDE397 in MTAP-null solid tumors has completed, including MTAP-null non-sm…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Investigation of REcurrence Mechanisms to Adjuvant osimertINib in Radically Resected EGFR-mutated NSCLC Patients
A clinical trial update describing an investigation into recurrence mechanisms of adjuvant osimertinib in patients with radically resected E…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors [Phase 1]
Phase 1 update on LY4066434, a pan-KRAS inhibitor, in KRAS-mutant solid tumors, including pancreatic ductal adenocarcinoma and non-small cel…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial [Phase 3]
A Phase 3 trial called INSIGHT is evaluating immunotherapy after surgery for people with early-stage non-small cell lung cancer who have no …
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Multicenter, Non-interventional, Descriptive Study to Assess Assay Concordance of HER2 IHC Testing in Chinese Pan-tumor Patients
AstraZeneca is conducting a multicenter, non-interventional study in Chinese pan-tumor patients to assess concordance of HER2 IHC testing ac…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Phase I Study of [111In]-FPI-2107 in EGFR Mutation-positive NSCLC [Phase 1]
A Phase I clinical trial evaluating the radiolabeled compound [111In]-FPI-2107 in patients with EGFR mutation-positive non-small cell lung c…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors [Phase 1, Phase 2]
Verastem is evaluating the KRAS G12D-mutated cancer drug VS-7375 in a Phase 1/2 study across several solid tumors, including pancreatic duct…
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CLINICAL_TRIALS other · 2026-04-22Clinical Trial Update: Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer [Phase 2]
This Phase 2 clinical trial evaluates adding TRC102 to standard chemotherapy with pemetrexed plus cisplatin or carboplatin during radiation …
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Immune Signature Analysis of Disease Progression in Post Immunotherapy Lung Cancer Patients
This clinical trial update describes analysis of immune signatures associated with disease progression in patients with non-small cell lung …
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: NSCLC Liquid Biopsies and Exhaled VOC
An ongoing clinical trial at St. Joseph's Healthcare Hamilton is evaluating liquid biopsy approaches (circulating tumor DNA) and exhaled vol…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: CHOICE:Decision Factor of EGFR-TKI in Chinese IV NSCLC
A ClinicalTrials.gov entry sponsored by AstraZeneca describes the CHOICE study evaluating decision factors for EGFR-TKI therapy in Chinese p…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients [Phase 1, Phase 2]
Clinical trial update for TNG462 in combination therapy for pancreatic ductal adenocarcinoma and non-small cell lung cancer, currently recru…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002) [Phase 3]
This is a Phase 3 randomized trial evaluating Intismeran Autogene (V940) plus pembrolizumab versus placebo plus pembrolizumab in non-small c…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: An Observational Study to Assess the Effectiveness and Safety of a Cemiplimab in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) in Routine Clinical Practice Settings in Europe
An observational study to evaluate the effectiveness and safety of cemiplimab in adults with advanced non-small cell lung cancer in routine …
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors [Phase 1]
This first-in-human Phase 1 trial update reports ALX2004 for advanced or metastatic solid tumors and notes that the study is currently recru…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Efficacy and Safety of SKB264 Plus Anlotinib in EGFR-TKI-Resistant Advanced NSCLC With Liver Metastasis [Phase 2]
A Phase 2 clinical trial evaluating the combination of SKB264 and Anlotinib for EGFR-TKI-resistant advanced non-small cell lung cancer with …
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy for Stage III Non-small Cell Lung Cancer [Phase 2]
This entry reports the completion and posted results of a Phase 2 trial evaluating positron emission tomography and computed tomography to g…
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: A Phase II Study of Atezolizumab in Combination With Bevacizumab, Carboplatin or Cisplatin, and Pemetrexed for EGFR-mutant Metastatic Non-small Cell Lung Cancer Patients After Failure of EGFR Tyrosine Kinase Inhibitors. [Phase 2]
A Phase II trial evaluating a combination of atezolizumab, bevacizumab, carboplatin or cisplatin, and pemetrexed in patients with EGFR-mutan…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC) [Phase 3]
This is a Phase 3 study comparing Pfizer investigational PF-08046054/SGN-PDL1V to docetaxel in adults with previously treated PD-L1 positive…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Neoadjuvant IBI308, Bevacizumab, Plus Pemetrexed and Carboplatin Followed by Surgery in Unresectable Stage III NSCLC [Phase 2]
A Phase 2 neoadjuvant trial evaluating IBI308 with bevacizumab plus pemetrexed and carboplatin followed by surgery in unresectable stage III…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Overcoming Resistance to Immunotherapy Combining Gemcitabine With Ivonescimab in Advanced NSCLC [Phase 2]
Phase 2 clinical trial investigating gemcitabine plus ivonescimab for advanced non-small cell lung cancer is not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Iparomlimab and Tuvonralimab Injection Combined With SBRT in Patients With Early-Stage Non-Small Cell Lung Cancer [Phase 2]
A Phase 2 clinical trial investigating the combination of iparomlimab and tuvonralimab with stereotactic body radiotherapy for early-stage n…
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC [Phase 2]
A Phase 2 clinical trial comparing preoperative radioimmunotherapy versus chemoimmunotherapy for non-small cell lung cancer is currently rec…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Neoadjuvant Umbrella Trial for Patients With Unresectable Stage III NSCLC Harboring Rare Mutations. [Phase 2]
A Phase 2 neoadjuvant umbrella trial for patients with unresectable stage III non-small cell lung cancer and rare mutations is currently rec…