Non-small Cell Lung Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors [Phase 2]
Phase 2 study evaluating SOT101 in combination with pembrolizumab in selected advanced solid tumors was terminated; results have been posted…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1 [Phase 1, Phase 2]
A phase 1/2 trial evaluating afuresertib in combination with sintilimab and chemotherapy in selected solid tumors resistant to prior PD-1/PD…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Study of Safety and Efficacy of Brigatinib Plus Chemotherapy or Brigatinib Only in Advanced ALK-Positive Lung Cancer (MASTERPROTOCOL ALK) [Phase 2]
Clinical trial update for MASTERPROTOCOL ALK (NCT05200481) evaluating brigatinib with or without chemotherapy in advanced ALK-positive non-s…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Study of BDC-3042 as Single Agent and in Combination With Cemiplimab in Patients With Advanced Malignancies [Phase 1]
This clinical trial update notes the termination of a Phase 1 study of BDC-3042 as a single agent and in combination with cemiplimab in pati…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer [Phase 3]
Phase III open-label trial evaluating first-line osimertinib with or without datopotamab deruxtecan for EGFR-mutant locally advanced or meta…
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CLINICAL_TRIALS trial_result · 2025-11-13Clinical Trial Update: Study of Pembrolizumab/Vibostolimab Coformulation (MK-7684A) in Combination With Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (MK-7684A-007/KEYVIBE-007) [Phase 3]
Phase 3 trial MK-7684A-007/KEYVIBE-007 comparing pembrolizumab/vibostolimab coformulation plus chemotherapy to pembrolizumab plus chemothera…
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CLINICAL_TRIALS trial_result · 2025-11-13Clinical Trial Update: Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer [Phase 1]
This Phase 1 trial evaluates the safety, pharmacokinetics, and activity of GDC-1971 in combination with osimertinib for unresectable, locall…
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: Osimertinib and Gefitinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial update evaluating the EGFR inhibitors osimertinib and gefitinib in EGFR-inhibitor naïve patients with advanced EG…
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: Nivolumab in Combination With Plinabulin in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC) [Phase 1]
Phase 1 trial of nivolumab in combination with plinabulin for metastatic non-small cell lung cancer has completed.
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)-Japan Extension [Phase 3]
Phase 3 trial update comparing subcutaneous pembrolizumab coformulated with berahyaluronidase alfa (MK-3475A) to intravenous pembrolizumab i…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors [Phase 1, Phase 2]
Phase I/II trial of autologous T cells engineered to express T-cell receptors (TCRs) in patients with solid tumors was terminated with resul…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: TG4010 and Nivolumab in Patients With Lung Cancer [Phase 2]
Phase 2 trial update reporting completion of a study evaluating TG4010 in combination with nivolumab for non-small cell lung cancer, with re…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: A Study to Test Different Doses of BI 836880 Combined With Ezabenlimab in Patients With Advanced Non-small Cell Lung Cancer Followed by Other Types of Advanced Solid Tumours [Phase 1]
Phase 1 trial evaluating different doses of BI 836880 in combination with Ezabenlimab in patients with advanced non-small cell lung cancer; …
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Study of CHS-388 (Formerly Known as SRF388) in Patients With Advanced Solid Tumors [Phase 1]
This is a completed Phase 1 clinical trial update evaluating CHS-388 (formerly SRF388) in patients with advanced solid tumors, including cle…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: A Pilot Study of Blood-based Biomarkers for Response to Immune Checkpoint Inhibitors
A pilot clinical trial update evaluating blood-based biomarkers to predict response to immune checkpoint inhibitors in non-small cell lung c…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Study of MGY825 in Patients With Advanced Non-small Cell Lung Cancer [Phase 1]
A Phase 1 study of MGY825 in patients with advanced non-small cell lung cancer has been terminated.
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CLINICAL_TRIALS trial_result · 2025-11-05Clinical Trial Update: Radical RADiotherapy and Immunotherapy for Metastatic CAncer of the Lung (RRADICAL) [NA]
A clinical trial investigating radical radiotherapy in combination with immunotherapy for stage IV non-small cell lung cancer has completed,…
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CLINICAL_TRIALS trial_result · 2025-11-05Clinical Trial Update: Study of Boserolimab (MK-5890) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Adults With Advanced Solid Tumors (MK-5890-001) [Phase 1]
Phase 1 study evaluating Boserolimab (MK-5890) alone and in combination with Pembrolizumab (MK-3475) in adults with advanced solid tumors; t…
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CLINICAL_TRIALS trial_result · 2025-11-05Clinical Trial Update: Safety and Efficacy of Zimberelimab (AB122) in Combination With Domvanalimab (AB154) and Etrumadenant (AB928) in Patients With Previously Treated Non-Small Cell Lung Cancer [Phase 2]
A Phase 2 clinical trial update evaluating the safety and efficacy of a triple-drug combination (Zimberelimab, Domvanalimab, and Etrumadenan…
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CLINICAL_TRIALS trial_result · 2025-11-04Clinical Trial Update: A Study of Dabrafenib in Combination With Trametinib in Chinese Patients With BRAF V600E Mutant Metastatic NSCLC [Phase 2]
This Phase 2 trial evaluated dabrafenib in combination with trametinib in Chinese patients with BRAF V600E-mutant metastatic non-small cell …
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CLINICAL_TRIALS trial_result · 2025-11-04Clinical Trial Update: A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer [Phase 1, Phase 2]
Phase I/II study evaluating VLS-1488 in adults with advanced cancer; the trial is currently recruiting across multiple solid-tumor indicatio…
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CLINICAL_TRIALS trial_result · 2025-11-03Clinical Trial Update: Study of REGN5093-M114 (METxMET Antibody-Drug Conjugate) in Adult Patients With Mesenchymal Epithelial Transition Factor (MET) Overexpressing Advanced Cancer [Phase 1]
A Phase 1 trial of REGN5093-M114, a METxMET antibody-drug conjugate, in MET-overexpressing advanced cancers including non-small cell lung ca…
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Pivotal, Open-label, Randomized Study of Radiosurgery With or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases From Non-small Cell Lung Cancer (NSCLC). [Phase 3]
A pivotal Phase 3 trial evaluated adding Tumor Treating Fields (TTFields) to radiosurgery for patients with 1-10 brain metastases from non-s…
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Osimertinib Treatment on EGFR T790M Plasma Positive NSCLC Patients (APPLE) [Phase 2]
Phase 2 APPLE trial results evaluating osimertinib in EGFR T790M plasma-positive non-small cell lung cancer patients have been posted.
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CLINICAL_TRIALS trial_result · 2025-10-30Clinical Trial Update: An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC) [Phase 3]
Phase 3 trial comparing nivolumab alone, nivolumab plus ipilimumab, or nivolumab plus platinum-doublet chemotherapy versus platinum doublet …