Non-small Cell Lung Cancer
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CLINICAL_TRIALS research · 2024-12-06Clinical Trial Update: Korean Registry of Non-Small Cell Lung Cancer Patients with EGFR Mutation
This clinical trial registry entry notes that a Korean registry of non-small cell lung cancer patients with EGFR mutations is active but not…
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CLINICAL_TRIALS research · 2024-12-05Clinical Trial Update: A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer [Phase 1, Phase 2]
Phase 1/2 trial evaluating IOV-4001 for unresectable or metastatic melanoma and stage III/IV non-small cell lung cancer is currently recruit…
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CLINICAL_TRIALS research · 2024-12-05Clinical Trial Update: Chemotherapy Plus Immunotherapy Combined With SBRT as Neoadjuvant Therapy for Patients With Resectable NSCLC [Phase 2]
A Phase 2 trial evaluating chemotherapy plus immunotherapy with SBRT as neoadjuvant therapy for resectable non-small cell lung cancer; the s…
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: PET Imaging of Cancer Patients Using 68Ga-DOTA-Siglec-9
A clinical trial is evaluating the PET imaging tracer 68Ga-DOTA-Siglec-9 in cancer patients. The study is currently enrolling by invitation …
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Neo-Bio-ADAURA: a Phase II Study to Evaluate Mechanisms of Resistance to Neoadjuvant Osimertinib [Phase 2]
This document provides an update on a Phase II trial (Neo-Bio-ADAURA) evaluating mechanisms of resistance to neoadjuvant osimertinib in non-…
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients With Non-small Cell Lung Cancer Pursuing Stereotactic Body Radiotherapy (SBRT) [NA]
This clinical trial update describes using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to stage lymph nodes…
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Tumor Treating Fields (TTF) in Combination with Stereotactic Radiosurgery(SRS) for Brain Metastases from Non-small Cell Lung Cancer. [NA]
The document reports a clinical trial evaluating tumor treating fields in combination with stereotactic radiosurgery for brain metastases fr…
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CLINICAL_TRIALS research · 2024-12-02Clinical Trial Update: Exploring the Mechanism of Primary Resistance to Third-generation EGFR-TKIs as First-line Treatment in EGFR-positive Advanced NSCLC (PRECISE Study)
This study investigates mechanisms of primary resistance to first-line third-generation EGFR-TKIs in EGFR-mutant advanced non-small cell lun…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy in Patients Performed in Five Referred Centers
A multi-center study evaluating robotic-assisted (RATS), video-assisted (VATS), and open lung resections following neoadjuvant chemo-immunot…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: A Multicountry, Multicentre, Non-interventional, Retrospective Study to Determine Real-world Treatment Patterns and Associated Outcomes After First Line Osimertinib in Patients With Advanced and Metastatic NSCLC EGFRm in the GCC Region
A completed non-interventional retrospective study conducted across multiple countries aims to characterize real-world treatment patterns an…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Immuno-pet IMaging ResPonses AdministeRed Immune CheckpoiNt InhibiTor [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial from Radboud University Medical Center is evaluating immuno-PET imaging to assess responses to an immune ch…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Minimal Residual Disease Guiding Adjuvant Therapy in Stage I NSCLC [NA]
This clinical trial update describes a study evaluating whether minimal residual disease can guide adjuvant therapy in stage I non-small cel…
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CLINICAL_TRIALS research · 2024-11-26Clinical Trial Update: Tislelizumab Consolidation Therapy After Radiotherapy or Sequential Chemoradiation in Locally Advanced NSCLC Patients [Phase 2]
A Phase 2 clinical trial is evaluating tislelizumab as consolidation immunotherapy after radiotherapy or sequential chemoradiation in patien…
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CLINICAL_TRIALS research · 2024-11-26Clinical Trial Update: Study of BEBT-109 in Subjects With EGFR Exon 20 Insertion Mutations Non-Small Cell Lung Cancer [Phase 2]
BEBT-109 is being studied in a Phase 2 clinical trial for non-small cell lung cancer with EGFR Exon 20 insertion mutations; the study is cur…
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CLINICAL_TRIALS research · 2024-11-25Clinical Trial Update: Aumolertinib with or Without Chemotherapy As 1st Line Treatment in Locally Advanced or Metastatic Non-Small Cell Lung Cancer with Sensitizing EGFR Mutations [Phase 3]
Phase 3 trial evaluating Aumolertinib, with or without chemotherapy, as first-line treatment for locally advanced or metastatic non-small ce…
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CLINICAL_TRIALS research · 2024-11-25Clinical Trial Update: Cadonilimab Combined With Stereotactic Radiotherapy as Second-line Treatment for Brain Metastases [Phase 2]
Phase 2 clinical trial evaluating cadonilimab in combination with stereotactic radiotherapy as a second-line treatment for brain metastases …
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CLINICAL_TRIALS research · 2024-11-25Clinical Trial Update: Radiolabelled Nectin-4 Targeted LMW Probe PET/CT in Patients With Lung Lesions
A clinical trial evaluating a radiolabeled Nectin-4 targeted low-molecular-weight probe for PET/CT imaging in patients with lung lesions, cu…
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CLINICAL_TRIALS research · 2024-11-22Clinical Trial Update: Clinical Study of Neoadjuvant Chemotherapy and Immunotherapy Combined With Probiotics in Patients With Resectable NSCLC [Phase 2]
ClinicalTrials.gov report describes a Phase 2 neoadjuvant trial in resectable non-small cell lung cancer evaluating chemotherapy and immunot…
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CLINICAL_TRIALS research · 2024-11-22Clinical Trial Update: Phase II Clinical Study of Adebrelimab Combined with Apatinib in the Treatment of Locally Advanced Non-small Cell Lung Cancer Patients with Radiation Pneumonitis [Phase 2]
Phase II clinical study evaluating the combination of Adebrelimab and Apatinib in unresectable locally advanced non-small cell lung cancer, …
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CLINICAL_TRIALS research · 2024-11-21Clinical Trial Update: Predictive Multimodal Signatures Associated With Response to Treatment and Prognosis of Patients With Stage IV Non-small Cell Lung Cancer
Clinical trial update describing predictive multimodal signatures linked to treatment response and prognosis in patients with stage IV non-s…
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CLINICAL_TRIALS research · 2024-11-21Clinical Trial Update: TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases [Phase 2]
TYK Medicines is conducting a Phase 2 trial of TY-9591 for patients with EGFR-mutant non-small cell lung cancer, including those with brain …
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CLINICAL_TRIALS research · 2024-11-20Clinical Trial Update: Cerebrospinal Fluid Immune Microenvironment Mechanism in Anaplastic Lymphoma Kinase Positive Lung Cancer Patients [Phase 2]
Phase 2 clinical trial evaluating cerebrospinal fluid immune microenvironment mechanisms in ALK-positive non-small cell lung cancer. The stu…
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CLINICAL_TRIALS research · 2024-11-20Clinical Trial Update: Afatinib With CT and RT for EGFR-Mutant NSCLC [Phase 2]
A Phase 2 clinical trial at Massachusetts General Hospital is evaluating afatinib with concurrent chemotherapy and radiotherapy for EGFR-mut…
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CLINICAL_TRIALS research · 2024-11-19Clinical Trial Update: A Phase 2 Clinical Study of ABSK061 and ABSK043 [Phase 2]
Abbisko Therapeutics is recruiting for a Phase 2 study of ABSK061 and ABSK043 in multiple cancers, including HER2-positive gastric/gastroeso…
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CLINICAL_TRIALS research · 2024-11-19Clinical Trial Update: Propranolol Hydrochloride in Combination With Sintilimab and Platinum-based Chemotherapy for Treatment of Advanced Non-small Cell Lung Cancer [Phase 1]
Phase 1 trial evaluating propranolol hydrochloride in combination with sintilimab and platinum-based chemotherapy for advanced non-small cel…