Non-small Cell Lung Cancer
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CLINICAL_TRIALS research · 2025-02-18Clinical Trial Update: Clinical Research Platform Into Molecular Testing, Treatment and Outcome of (Non-)Small Cell Lung Carcinoma Patients
A clinical trial registry entry for a platform study evaluating molecular testing, treatment, and outcomes in non-small cell lung cancer and…
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CLINICAL_TRIALS research · 2025-02-14Clinical Trial Update: First-in-human Study of OVM-200 as a Therapeutic Cancer Vaccine [Phase 1]
First-in-human Phase 1 study of OVM-200, a therapeutic cancer vaccine, being tested in prostate cancer, non-small cell lung cancer, and ovar…
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CLINICAL_TRIALS research · 2025-02-14Clinical Trial Update: Allogeneic PB103 (NK Cells) Therapy in Non-small Cell Lung Cancer (NSCLC) Patients [Phase 1, Phase 2]
This document provides a status update on an ongoing Phase 1/2 trial evaluating allogeneic PB103 natural killer (NK) cell therapy in non-sma…
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CLINICAL_TRIALS research · 2025-02-13Clinical Trial Update: Durvalumab and Stereotactic Radiotherapy for Advanced NSCLC [Phase 2]
Phase 2 clinical trial evaluating durvalumab in combination with stereotactic radiotherapy for advanced Non-Small Cell Lung Cancer; the stud…
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CLINICAL_TRIALS research · 2025-02-13Clinical Trial Update: A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies [Phase 1, Phase 2]
This document reports a Phase 1/Phase 2 clinical trial evaluating GV20-0251 as monotherapy and in combination with pembrolizumab in several …
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CLINICAL_TRIALS research · 2025-02-13Clinical Trial Update: Early Prediction of Therapeutic Response to Targeted Therapy in Stage IIIB/IV or Recurrent Lung Cancer Patients [Phase 1]
Phase 1 clinical trial update on early prediction of therapeutic response to targeted therapy in stage IIIB/IV or recurrent non-small cell l…
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CLINICAL_TRIALS research · 2025-02-12Clinical Trial Update: Pharmacokinetic Study of HS-10365 Capsule in Subjects with Hepatic Impairment and Normal Hepatic Function [Phase 1]
This is a Phase 1 pharmacokinetic study evaluating HS-10365 capsule in subjects with hepatic impairment and normal hepatic function, in the …
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CLINICAL_TRIALS research · 2025-02-12Clinical Trial Update: Pharmacokinetic Study of HS-10241 Tablets in Subjects with Hepatic Impairment and Normal Hepatic Function [Phase 1]
This Phase 1 pharmacokinetic study evaluates HS-10241 in subjects with hepatic impairment and normal hepatic function to inform dosing for a…
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CLINICAL_TRIALS research · 2025-02-10Clinical Trial Update: Low Dose Radiotherapy Combined With Sintilimab and Chemotherapy as Neoadjuvant Therapy for Stage II-III NSCLC [Phase 2]
This clinical trial update reports a Phase 2 study evaluating low-dose radiotherapy combined with sintilimab and chemotherapy as neoadjuvant…
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CLINICAL_TRIALS research · 2025-02-07Clinical Trial Update: XNW27011 Study of Advanced Solid Tumor Subjects Who Failed Standard Therapies. [Phase 1, Phase 2]
Clinical trial update indicating an early-phase study of XNW27011 for multiple advanced solid tumors is currently recruiting.
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CLINICAL_TRIALS research · 2025-02-07Clinical Trial Update: GT201 Injection in Combination with Teraplizumab Injection for Treatment of Patients with Non-small Cell Lung Cancer [NA]
This clinical trial update reports a study of GT201 Injection in combination with Teraplizumab Injection for non-small cell lung cancer, wit…
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CLINICAL_TRIALS research · 2025-02-06Clinical Trial Update: Effectiveness of Respiratory Muscle Training with a Mobile Application After Lobectomy [NA]
A clinical trial investigates whether respiratory muscle training delivered via a mobile app improves outcomes after lobectomy for non-small…
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CLINICAL_TRIALS research · 2025-02-06Clinical Trial Update: Retrospective Observational Study on Prediction of Response to PD-1 Immunotherapy in Patients with NSCLC
A retrospective observational study is being conducted to predict response to PD-1 immunotherapy in patients with advanced non-small cell lu…
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CLINICAL_TRIALS research · 2025-02-06Clinical Trial Update: A Study of PLB1001 in Non-small Cell Lung Cancer With c-Met Dysregulation(KUNPENG) [Phase 2]
A Phase 2 clinical trial evaluating PLB1001 in patients with non-small cell lung cancer that have c-Met dysregulation; the study status is A…
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: Circulating and Molecular Markers Involved in the Processes of Cachexia, Anorexia and Sarcopenia in Patients With NSCLC
This clinical trial investigates circulating and molecular biomarkers involved in cachexia, anorexia, and sarcopenia in patients with non-sm…
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: The Beneficial Value of PET/CT in the Follow-up of Stage III Non-small Cell Lung Cancer Patients [NA]
This clinical trial update explores the potential value of PET/CT in the follow-up care of patients with Stage III non-small cell lung cance…
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: A Prospective Study of Plasma Genotyping as a Noninvasive Biomarker for Genotype-directed Cancer Care
This entry describes a prospective clinical trial evaluating plasma genotyping as a noninvasive biomarker to guide genotype-directed cancer …
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CLINICAL_TRIALS research · 2025-02-04Clinical Trial Update: An Observational Study to Evaluate the Clinical Utility of the Oncomine Precision Assay Within the Exactis Network
This update reports the completion of an observational study evaluating the clinical utility of the Oncomine Precision Assay within the Exac…
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CLINICAL_TRIALS research · 2025-02-04Clinical Trial Update: Transcriptional Framework for the Molecular Diagnosis of Response to Immunotherapy in Lung Cancer With Agnostic Potential
This clinical trial update describes a transcriptional framework intended to molecularly diagnose response to immunotherapy in non-small cel…
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CLINICAL_TRIALS research · 2025-01-31Clinical Trial Update: Genomic Investigation of Unusual Responders
This clinical trial update describes a University Health Network study investigating genomic factors in unusual responders across multiple c…
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CLINICAL_TRIALS research · 2025-01-31Clinical Trial Update: Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 MAb, Administered Alone and in Combination with a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study) [Phase 1, Phase 2]
Phase 1/2 MORNINGSTAR trial evaluating mavrostobart (PT199), an anti-CD73 antibody, alone or with a PD-1 inhibitor or chemotherapy in non-sm…
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CLINICAL_TRIALS research · 2025-01-30Clinical Trial Update: Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD) [Phase 2]
Phase 2 platform clinical trial ORCHARD investigates treatment options for advanced non-small cell lung cancer in patients who progressed on…
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CLINICAL_TRIALS research · 2025-01-30Clinical Trial Update: Digital Lifestyle Intervention for Lung Cancer Survivors [NA]
An ongoing clinical study is evaluating a digital lifestyle intervention for survivors of non-small cell lung cancer and is currently recrui…
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CLINICAL_TRIALS research · 2025-01-29Clinical Trial Update: A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study of the bispecific antibody MCLA-158 in patients with advanced solid tumors. Recruitme…
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CLINICAL_TRIALS research · 2025-01-28Clinical Trial Update: Evaluation of a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer (PragmaTIL) [Phase 2]
Phase 2 clinical trial evaluating a pragmatic adoptive cell therapy approach using an IL2 analog (ANV419) versus high-dose IL-2 after tumor-…