Non-small Cell Lung Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-05-21Clinical Trial Update: A Clinical Study on the Efficacy and Safety of the Combination of Limertinib and Bevacizumab Versus Limertinib as First-line Treatment for NSCLC. [Phase 2]
Phase 2 clinical trial evaluating limertinib plus bevacizumab versus limertinib as first-line treatment for EGFR-mutant, PD-L1 positive adva…
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CLINICAL_TRIALS research · 2025-05-21Clinical Trial Update: National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer [Phase 2]
This entry covers the National Lung Matrix Trial, a multi-drug Phase II study in non-small cell lung cancer, with the trial currently active…
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CLINICAL_TRIALS research · 2025-05-21Clinical Trial Update: Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations.
A clinical trial is recruiting to evaluate how bone metastases in non-small cell lung cancer with actionable driver mutations respond to tyr…
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01) [Phase 1, Phase 2]
KL264-01, a Trop2-targeted antibody-drug conjugate, is being studied in a Phase 1/2 trial for advanced unresectable or metastatic solid tumo…
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: Trial of ctDNA of Guidance to Determine PostOperative Radiation Therapy [EARLY_Phase 1]
It announces an early-phase trial exploring whether circulating tumor DNA can guide postoperative radiation therapy decisions in non-small c…
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02) [Phase 1]
This clinical trial update reports an ongoing Phase 1 study evaluating datopotamab deruxtecan in combination with pembrolizumab, with or wit…
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: TGRX-326 Chinese Phase I for Advanced Non-small Cell Lung Cancer (NSCLC) [Phase 1]
This clinical trial update describes a Phase 1 study of the experimental agent TGRX-326 for advanced non-small cell lung cancer conducted in…
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: Perioperative Tislelizumab for Resectable II-IIIB(N2) KRAS-mutated Nonsquamous Non-small Cell Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating perioperative tislelizumab in patients with resectable KRAS-mutated, nonsquamous non-small cell lung cance…
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients [Phase 1, Phase 2]
Status update on a Phase 1/2 trial evaluating Avutometinib (VS-6766) plus Adagrasib in KRAS G12C non-small cell lung cancer. The study is cu…
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan
This clinical trial explores combining circulating tumor DNA mutation/methylation profiling with PET-CT to predict lymph node metastasis in …
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: TGRX-326 Chinese Phase II for Advanced Non-small Cell Lung Cancer (NSCLC) [Phase 2]
A Phase II trial of TGRX-326 for advanced non-small cell lung cancer in China is currently active but not recruiting. The study is sponsored…
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: TGRX-326 Chinese Phase III for Advanced Non-small Cell Lung Cancer (NSCLC) [Phase 3]
Phase 3 clinical trial in China evaluating TGRX-326 for advanced non-small cell lung cancer is currently active but not recruiting. Sponsore…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE) [Phase 2]
A Phase 2 clinical trial (MATISSE) is evaluating IPH5201 in combination with durvalumab in patients with resectable non-small cell lung canc…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: Lobectomy-First vs. Lymphadenectomy-First for Operable NSCLC (LOFTY) [NA]
A clinical trial called LOFTY is evaluating whether lobectomy-first or lymphadenectomy-first surgical strategies are preferable for operable…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: A Phase 1/2 Study to Evaluate the Safety, Tolerability and PK of JIN-A02 in Patients With EGFR Mutant Advanced NSCLC [Phase 1, Phase 2]
This document describes a Phase 1/2 clinical trial evaluating the safety, tolerability, and pharmacokinetics of JIN-A02 in patients with EGF…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: The Prospective Non-randomized Case-control Study From Real-world Lung Cancer Patients
A prospective non-randomized case-control real-world study in non-small cell lung cancer sponsored by Samsung Medical Center is currently AC…
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: A Pilot Study of Dacomitinib With or Without Osimertinib for Patients With Metastatic EGFR Mutant Lung Cancers With Disease Progression on Osimertinib. [EARLY_Phase 1]
An early-phase pilot study evaluating dacomitinib with or without osimertinib in patients with metastatic EGFR-mutant non-small cell lung ca…
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) [Phase 2, Phase 3]
SWOG reports a Phase 2/3 trial evaluating N-803 (ALT-803) in combination with pembrolizumab versus standard treatment for advanced non-small…
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: Neoadjuvant Sacituzumab Govitecan Plus Pembrolizumab in Resectable Non-Small Cell Lung Cancer [Phase 2]
A Phase 2 neoadjuvant trial evaluating sacituzumab govitecan in combination with pembrolizumab for resectable non-small cell lung cancer is …
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: Clinical Study of Combined EphA2-targeted CAR-DC and CAR-T Cell Therapy for Non-small Cell Lung Cancer [Phase 1]
This Phase 1 clinical study evaluates a combined EphA2-targeted CAR-DC and CAR-T cell therapy for non-small cell lung cancer and is currentl…
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial [Phase 2]
This is a Phase 2 pilot pragmatic clinical trial updating on strategies to avoid radiation therapy for brain metastases in NSCLC patients wh…
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CLINICAL_TRIALS research · 2025-05-14Clinical Trial Update: JS111 in Patients With Advanced NSCLC Harboring EGFR Mutations [Phase 1, Phase 2]
A Phase 1/2 clinical trial of JS111 is recruiting for patients with advanced non-small cell lung cancer harboring EGFR mutations.
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CLINICAL_TRIALS research · 2025-05-14Clinical Trial Update: High-Dose Firmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed in the Treatment of EGFR-Mutated Non-Small Cell Lung Cancer With Leptomeningeal Metastasis [Phase 2]
Phase 2 clinical trial evaluating high-dose Firmonertinib with Bevacizumab and intrathecal Pemetrexed for EGFR-mutated non-small cell lung c…
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CLINICAL_TRIALS research · 2025-05-14Clinical Trial Update: Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer [Phase 1, Phase 2]
This update outlines a Phase 1/2 trial of dose-deescalated 3-fraction stereotactic body radiotherapy for centrally located non-small cell lu…
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CLINICAL_TRIALS research · 2025-05-14Clinical Trial Update: MWA With or Without Furmonertinib for Early-Stage Non-Small Cell Lung Cancer [NA]
A clinical trial is evaluating microwave ablation with or without furmonertinib for early-stage non-small cell lung cancer. The study is cur…